Keywords: GPCR، G گیرنده پروتئینی همراه است; cLRSPR, Coupled long-range surface-plasmon resonance; EGFR, Epidermal growth factor receptor; GPCR, G protein coupled receptor; IC50, Inhibitory concentration at 50%; IRSPR, Infrared surface-plasmon resonance; LRSPR, Long-range surface-plasmon resonance;
مقالات ISI GPCR، G گیرنده پروتئینی همراه است (ترجمه نشده)
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Keywords: GPCR، G گیرنده پروتئینی همراه است; DR, dorsal raphe; DMH, dorsomedial hypothalamus; GPCR, G protein coupled receptor; GABA, gamma amino butyric acid; LDT, laterodorsal tegmental nucleus; LC, locus coeruleus; LPC, lysophosphatydylcholine; NMDA, N-methyl-d-aspartate; NSCC, non-selective cati
Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data
Keywords: GPCR، G گیرنده پروتئینی همراه است; CRC, concentration response curve; EC50, effective agonist concentration for 50% maximum response; Emax, maximum system response; GPCR, G protein coupled receptor; D2R, dopamine D2 receptor; GTPγS, guanosine 5′-O-[γ-thio]triphosphate; KA, agonist equilibr
The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions
Keywords: GPCR، G گیرنده پروتئینی همراه است; Asthma; Eosinophil; Eotaxin; PI3KγAHR, airway hyperresponsiveness; ERK, extracellular signal-regulated kinase; GPCR, G protein coupled receptor; PI3K, phosphoinositide-3 kinase; RPMI, Roswell Park Memorial Institute; PI, propidium iodine
Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons
Keywords: GPCR، G گیرنده پروتئینی همراه است; ATP, adenosine triphosphate; CNS, central nervous system; DMEM, Dulbecco׳s Modified Eagle Medium; DRG, dorsal root ganglion neurons; GIRK, G-protein inward rectifying potassium channels; GPCR, G protein coupled receptor; GTP, guanosine triphosphate; HEPES
Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles
Keywords: GPCR، G گیرنده پروتئینی همراه است; PLGA, poly(dl-lactic-co-glycolic acid); GPCR, G protein coupled receptor; Mw, molecular weight; EDC, 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride; Sulfo-NHS, N-hydroxysulfosuccinimide; MES, 2-(N-morpholino)ethanesulfonic acid sodium salt; B
The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function
Keywords: GPCR، G گیرنده پروتئینی همراه است; FGFR, FGF receptor; EGFR, EGF receptor; 2-AG, 2-arachidonylglycerol; DAGL, DAG diacylglycerol lipase; eCB, endocannabinoid; NSC, neural stem cells; SVZ, subventricular zone; GPCR, G protein coupled receptor; DDR1, discoidin domain receptor 1; FZD, frizzle
Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective
Keywords: GPCR، G گیرنده پروتئینی همراه است; GPCR, G protein coupled receptor; MD, molecular dynamics; DEER, double electron–electron resonance; TM, transmembrane; NMA, normal mode analysis; Meta, metarhodopsin; CT, C terminus; myr, myristoylationGα; hydrophobic triad; IC2; β2/β3 loop; conformationa
EGFR dependent subcellular communication was responsible for morphine mediated AC superactivation
Keywords: GPCR، G گیرنده پروتئینی همراه است; MOR, mu opioid receptor; GPCR, G protein coupled receptor; HA, hemagglutinin; TCA, trichloroacetic acid; FACS, fluorescence-activated cell sorting; PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; PTX, pertussis toxinMOR; EGFR; AC sup
Estrogen receptor dependent gene expression by osteoblasts – Direct, indirect, circumspect, and speculative effects
Keywords: GPCR، G گیرنده پروتئینی همراه است; ER, estrogen receptor; AF-1, activation function 1; DBD, DNA binding domain; ERE, estrogen response element; LBD, ligand binding domain; AF-2, activation function 2; GPCR, G protein coupled receptor; GPER, G protein coupled estrogen receptor; ERR, estroge
The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays
Keywords: GPCR، G گیرنده پروتئینی همراه است; B2AR, (inactive) β2-adrenergic receptor; B2AR∗, active β2-adrenergic receptor; EF, enrichment factor; GPCR, G protein coupled receptor; IFP, interaction fingerprint; tIFP, Tanimoto coefficient derived from IFPs; VLS, virtual ligand screening; MD, molecula
Structure, function and pathophysiology of protease activated receptors
Keywords: GPCR، G گیرنده پروتئینی همراه است; Protease; Protease activated receptor; PAR; GPCRAP, activating peptide; APC, activated protein C; ECL, extracellular loop; EGFR, epidermal growth factor receptor; EPCR, endothelial protein kinase C receptor; GPCR, G protein coupled receptor; HRS, hepatocy
Phosphatidic acid potentiates Gαq stimulation of phospholipase C-β1 signaling
Keywords: GPCR، G گیرنده پروتئینی همراه است; Gαq; GPCR; Phosphatidic acid; Phospholipase C-β; Phospholipase DDGK, diacylglycerol kinase; GAP, GTPase activating protein; GPCR, G protein coupled receptor; PA, phosphatidic acid; PLC-β, phospholipase C-β; PLD, phospholipase D; PMA, 4β-phorbol 12-myrista
Caveolin-1 affects serotonin binding and cell surface levels of human 5-HT7(a) receptors
Keywords: GPCR، G گیرنده پروتئینی همراه است; 5-HT, 5-hydroxytryptamine, serotonin; 5-MeOT, 5-metoxytryptamine; GPCR, G protein coupled receptor; Cav-1, caveolin-1; siRNA, small interfering RNA; KD, dissociation constant; MβCD, methyl-β-cyclodextrinCaveolae; Lipid rafts; Receptor trafficking; GPCR; 5
Allosteric effects of antagonists on signalling by the chemokine receptor CCR5
Keywords: GPCR، G گیرنده پروتئینی همراه است; CHO, cells, Chinese hamster ovary cells; FCS, foetal calf serum; FITC, fluorescein isothiocyanate; GPCR, G protein coupled receptor; GRK, G protein coupled receptor kinase; HIV, human immunodeficiency virus; MCP, monocyte chemoattractant protein; MIP, mac
Heterodimerization and surface localization of G protein coupled receptors
Keywords: GPCR، G گیرنده پروتئینی همراه است; GPCR, G protein coupled receptor; RAMPS, receptor activity modifying proteins; AR, adrenergic receptor; ORs, olfactory receptors; PLCβ, phospholipase Cβ; PIP2, phosphatidylinositol 4,5 bisphosphate; IP3, inositol 1,4,5 trisphosphate; IP3R, IP3 receptor; D
Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family
Keywords: GPCR، G گیرنده پروتئینی همراه است; CPG, central pattern generator; GPCR, G protein coupled receptor; DA, dopamine; DAR, dopamine receptor; PKA, protein kinase A; PP2A, protein phosphatase 2A; PTX, pertussis toxin; Et-18-OCH3, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine; IBMX,
The ocular albinism type 1 gene product, OA1, spans intracellular membranes 7 times
Keywords: GPCR، G گیرنده پروتئینی همراه است; membrane topology; lysosome; cellular localization; ocular albinism type 1; melanosome; G protein coupled receptor; selective membrane permeabilizationOA1, ocular albinism type 1; GPCR, G protein coupled receptor; HA, influenza hemagglutinin epitope; LAMP
G protein coupled receptor structure and activation
Keywords: GPCR، G گیرنده پروتئینی همراه است; β2AR, beta 2 adrenoceptor; GPCR, G protein coupled receptor; TM, transmembraneGPCR; 7TM; Structure; Conformational change; Efficacy
Silencing of filamin A gene expression inhibits Ca2+-sensing receptor signaling
Keywords: GPCR، G گیرنده پروتئینی همراه است; GPCR, G protein coupled receptor; HEK, human embryo kidney; CaR, Ca2+-sensing receptor; SAPK/JNK, stress-activated protein kinases/c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; SEK1, SAPK/ERK kinase 1; MAPK, mitogen-activated protei
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε
Keywords: GPCR، G گیرنده پروتئینی همراه است; Grm1, metabotropic glutamate receptor 1; GPCR, G protein coupled receptor; PLC, phospholipase C; PIP2, bisphosphoinositide; IP3, inositol triphosphate; DAG, diacylglycerol; ER, endoplasmic reticulum; PKC, protein kinase C; MAPK, mitogen activated protein
Ocular albinism 1 protein: Trafficking and function when expressed in Saccharomyces cerevisiae
Keywords: GPCR، G گیرنده پروتئینی همراه است; ocular albinism; G protein couple receptor; late endosomeOA1, ocular albinism 1; GPCR, G protein coupled receptor; SST5, somatostatin receptor; ALP, alkaline phosphatase; CPY, carboxypeptidase Y; PVC, prevacuolar compartment
A review of TRP channels splicing
Keywords: GPCR، G گیرنده پروتئینی همراه است; aas, aminoacids; ANK, ankirin repeat; bp, base pairs; CaM, calmodulin binding site; DAG, diacylglycerol; DRG, dorsal root ganglia; 5′,6′-EET, 5′,6′-epoxyeicosatrienoic acid; EST, expressed sequence tag; GPCR, G protein coupled receptor; hnRNPs, heterogene
Orphan neuropeptides: Novel neuropeptides modulating sleep or feeding
Keywords: GPCR، G گیرنده پروتئینی همراه است; GPCR, G protein coupled receptor; 5HT, 5-hydroxytryptamine; CNS, central nervous system; ORL-1 receptor, opioid receptor like-1 receptor; GABA, gamma-aminobutyric acid; REM, rapid eye movement; TH, tyrosine hydroxylase; EEG, electroencephalogram; i.c.v.,
Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands
Keywords: GPCR، G گیرنده پروتئینی همراه است; GPCR, G protein coupled receptor; CHO-NLFNYK-FL, N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine-fluorescein; CHO-NLFNYK-TMR, N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine-tetramethyrhodamine; CHO-NLF, N-formyl-norleucyl-
Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting β1 integrin in HEK293 cells
Keywords: GPCR، G گیرنده پروتئینی همراه است; ECM, extracellular matrix; EGF, epidermal growth factor; GPCR, G protein coupled receptor; IGF, insulin-like growth factor; LPA, lysophosphatidic acid; PDGFR, platelet-derived growth factor receptor; RTK, receptor tyrosine kinase; Sph, sphingosine-1-phosp