کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2808708 | 1157825 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Orphan neuropeptides: Novel neuropeptides modulating sleep or feeding Orphan neuropeptides: Novel neuropeptides modulating sleep or feeding](/preview/png/2808708.png)
Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identify novel neuropeptides. Thirteen new neuropeptide families have since been discovered. In this review we will describe the orphan GPCR-based approach that led to these discoveries and present its impact on two specific physiological responses, feeding and sleep. In particular, we will discuss the modulatory roles of the hypocretins/orexins and of neuropeptide S in sleep and awakening and those of ghrelin and melanin concentrating hormone in food intake.
Journal: Neuropeptides - Volume 40, Issue 4, August 2006, Pages 233–243