Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1â²,2â²:1,5]pyrazolo[3,4-d]pyrimidines
Keywords: Kinase inhibitor; VEGFR; GSK; ErB; EGFR;
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Targeted Inhibition of β-Adrenergic Receptor Kinase-1-Associated Phosphoinositide-3 Kinase Activity Preserves β-Adrenergic Receptor Signaling and Prolongs Survival in Heart Failure Induced by Calsequestrin Overexpression
Keywords: βAR; β-adrenergic receptor; βARK1; βAR kinase-1; cAMP; cyclic adenosine monophosphate; CSQ; calsequestrin; GSK; glycogen synthase kinase 3β; ISO; isoproterenol; MAPKs; mitogen-activated protein kinases; PKB; protein kinase B; PI3K; phosphoinositide-3
Ins(1,4,5)P3 receptors and inositol phosphates in the heart-evolutionary artefacts or active signal transducers?
Keywords: Inositol phosphates; Phospholipase C; Arrhythmia; Hypertrophy; α1-AR; α1-adrenergic receptor; ANP; atrial natriuretic factor; APD; action potential duration; CaMKII; Ca2+/calmodulin-dependent protein kinase II; CnA; calcineurin A; DAG; sn-1,2-diacylglyc
Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPARγ agonists: evidence for disparate functional effects which are independent of NF-κB and PPARγ
Keywords: COX; cyclooxygenase; PPAR; peroxisome proliferator-activated receptor; 15d-PGJ2; 15-deoxy-Î12,14 prostaglandin J2; HRP; horseradish peroxidase; BADGE; bisphenol A diglycidyl ether; PKB; protein kinase B; mPGES; microsomal prostaglandin E synthase; GSK; g
Neuro-modulation, aminergic neuro-disinhibition and neuro-degeneration.
Keywords: APP; amyloid precursor protein; Aβ; amyloid β; ATP; adenosine triphosphate; CaMK; calcium/calmodulin-dependent (protein) kinase; COX; cytochrome oxidase; ERK; extra-cellularly regulated kinase; GSK; glycogen synthase kinase; HIT; molecular change of rec
A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models
Keywords: Neural basis of behavior; Learning and memory: pharmacology; Aβ1-40; β-amyloid peptide 1-40; AChE; acetylcholinesterase; BDNF; brain derived neurotrophic factor; ChAT; choline acetyltransferase; CHOm2 cells; Chinese hamster ovary cells transfected w
Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
Keywords: AEA; anandamide; DNBS; dinitrobenzene sulphonic acid; ERK; extracellular-regulated kinase; FAAH; fatty acid amide hydrolase; GSK; glycogen synthase kinase; LPA; lysophosphatidic acid; MAPK; mitogen-activated protein kinase; NE; noladin ether; PI3K; phosph
Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction
Keywords: ACE; angiotensin converting enzyme; AM; adrenomedullin; ANP; atrial natriuretic peptide; AT-II; angiotensin-II; BNP; brain natriuretic peptide; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CGPP; calcitonin gene-related pepti
Peptide inhibitors of protein kinases-discovery, characterisation and use
Keywords: AKAP; A-Kinase Anchoring Protein; EGF-R; Epidermal Growth Factor-Receptor; GSK; Glycogen Synthase Kinase; IC50; concentration of compound to achieve 50% inhibition; JIP; JNK Interacting Protein; JNK; c-Jun N-terminal Kinase; Ki; inhibition constant; MLCK;