
The Top1 paradox: Friend and foe of the eukaryotic genome
Keywords: Top1; topoisomerase I; DSB; double-strand break; RNAP; RNA polymerase; GCR; gross chromosomal rearrangement; CPT; camptothecin; G4; guanine quadruplex; TNR; trinucleotide repeat; CSR; class-switch recombination; AID; activation-induced cytosine deaminase;