Keywords: h، انسان; PRL, prolactin; GH, growth hormone; PL, placenta lactogen; h, human; o, ovine; b, bovine; rb, rabbit; p, porcine; r, rat; m, murine; R, receptor; bp, binding protein; ECD, extracellular domain; rec, recombinant; h, hours; A, absorbance; SDS–PAGE, sodium d
مقالات ISI h، انسان (ترجمه نشده)
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Enhanced expression of human prostaglandin H synthase-2 in the yeast Pichia pastoris and removal of the C-terminal tag with bovine carboxypeptidase A
Keywords: h، انسان; AA, arachidonic acid; AOX1, alcohol oxidase 1; boCPA, bovine carboxypeptidase A; CT, threshold cycle; GAP, glyceraldehyde 3-phosphate dehydrogenase; h, human; HIS4, histidinol dehydrogenase; qPCR, quantitative PCR; PGHS, prostaglandin H synthase; WCW, wet
Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells
Keywords: h، انسان; BCR, B cell receptor; chSM201, chimeric SM201; FcγRIIB, inhibitory IgG receptor; ICs, immune complexes; ITAM, immunoreceptor tyrosine-based activating motif; ITIM, immunoreceptor tyrosine-based inhibitory motif; h, human; rSM201, rat SM201Autoimmune disea
Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities
Keywords: h، انسان; Abu, α-aminobutanoyl; Agm, agmatine; Apa, 5-aminopentanoyl; Dat, des-amino-tyrosine; EF, ejection fraction; Fpa5, pentafluoro-Phe; Gab, gamma-amino-butanoyl; GH, growth hormone; GHRH, GH-releasing hormone; h, human; IGF, insulin-like growth factor; i.v.,
Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1–27NH2-induced growth hormone secretion in cultured chicken pituitary cells
Keywords: h، انسان; c, chicken; h, human; SST, somatostatin peptide; CST, cortistatin peptide; SSTR, somatostatin receptor; GH, growth hormone; GHRH, growth hormone-releasing hormone; GHRHR1, GHRH type I receptor; GHRHR2, GHRH type II receptor; GHRH-LP, GHRH-like peptide; CH
Special aspects of interleukin-33 and the IL-33 receptor complex
Keywords: h، انسان; aa, amino acid; h, human; m, mouse; IL-1RAcP, interleukin-1 receptor accessory proteinInterleukin-33 processing; IL-33 release; Intracellular IL-33; IL-33 receptor complex; IL-33 signaling
NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain
Keywords: h، انسان; h, human; NT, neurotensin; NTS1−/−, NTS1 knock-out; NTS2−/−, NTS2 knock-out; WT, wild-typeAnalgesia; NT69L; NT79; NT72; Tolerance; Writhing
Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box
Keywords: h، انسان; CBP, CREB-binding protein; h, human; InsP, insulin promoter; KLF, Krüppel-like factor; MAO B, monoamine oxidase B; mut, mutated; PDX1, pancreatic duodenal homeobox protein 1; SEAP, secreted alkaline phosphatase; Sp1, specificity protein 1; TIEG, TGF-β-ind
The cysteine-rich domain of human T1R3 is necessary for the interaction between human T1R2–T1R3 sweet receptors and a sweet-tasting protein, thaumatin
Keywords: h، انسان; Thaumatin; Sweet-tasting protein; Sweet receptor; Cell-based assay; Chimeric human–mouse sweet receptorsHEK293, human embryonic kidney 293; h, human; m, mouse; CRD, cysteine-rich domain; GPCRs, G-protein-coupled receptors; NTD, N-terminal domain; TMD, tra
Structure–function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor
Keywords: h، انسان; AM, adrenomedullin; CGRP, calcitonin gene-related peptide; C-tail, cytoplasmic C-terminal tail; CLR, calcitonin receptor-like receptor; GPCR, G protein-coupled receptor; GRK, GPCR kinase; h, human; HEK, human embryonic kidney; Hyg, hygromycin; RAMP, recep
Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes
Keywords: h، انسان; NPY, neuropeptide Y; PYY, peptide YY; PP, pancreatic polypeptide; GPCR, G protein-coupled receptor; wt, wild type; h, human; p, porcine; PCR, polymerase chain reaction; GFP, green fluorescent protein; HEK, human embryonic kidney; PBS, phosphate-buffered s
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties
Keywords: h، انسان; NPY, neuropeptide Y; PYY, peptide YY; zf, zebrafish; h, human; ch, chicken; p, porcine; 3R, third round of genome doubling (teleost-specific)Gene duplication; Medaka; NPY-receptor; Peptide YY; Zebrafish
Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R
Keywords: h، انسان; E2 loop, second extracellular loop; gp, guinea-pig; GPCR, G protein-coupled receptor; h, human; hgpE2H1R, human histamine H1R with gp E2-loop; hgpNgpE2H1R, human histamine H1R with gp N-terminus and gp E2-loop; H1R, histamine H1 receptor; MEP, mepyramineH
Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex
Keywords: h، انسان; h, human; WT, wild-type; PDC, pyruvate dehydrogenase complex; E1, pyruvate dehydrogenase; E2, dihydrolipoamide acetyltransferase; E3, dihydrolipoamide dehydrogenase; BP, E3-binding protein; L3S1 (di-domain), the lipoyl domain (L3); first hinge region, E3-
Modulation of histamine H3 receptor function by monovalent ions
Keywords: h، انسان; GPCR, G protein-coupled receptor; h, human; H3R, histamine H3 receptor; H4R, histamine H4 receptor; TM, transmembrane domain; HA, histamine; THIO, thioperamide; NAMH, Nα-methylhistamineHistamine H3 receptor; Constitutive activity; Gi/Go-proteins; GTPase;
Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil
Keywords: h، انسان; ABC, ATP binding cassette; DMEM, Dulbecco's Modified Eagle Medium; EMEM, Eagle's minimum essential medium; FBS, Fetal bovine serum; HBSS, Hank's balanced salt solution; HEPES, N-hydroxyethylpiperazine-N′-2-ethanesulfonate; h, human; MDCKII, Madin–Darby Ca
Improved T and B cell recovery by the transfer of slowly dividing human hematopoietic stem cells
Keywords: h، انسان; BMC, bone marrow cells; h, human; FDF, fast dividing fraction; HSC, hematopoietic stem cells; LNC, lymph node cells; PEC, peritoneal exudate cells; SC, spleen cells; SDF, slow dividing fraction; TC, thymocytes; UCB, umbilical cord bloodHematopoietic stem
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
Keywords: h، انسان; AhR, aryl hydrocarbon receptor; XRE, xenobiotic-responsive element; CYP, cytochrome P450; CAR, constitutive androstane receptor; RXRα, retinoid X receptor α; h, human; PB, phenobarbital; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; C
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists
Keywords: h، انسان; AdoR, adenosine receptor(s); CADO, 2-chloroadenosine; [3H]CCPA, [3H]2-chloro-N6-cyclopentyladenosine; CHO, Chinese hamster ovary; CPA, N6-cyclopentyladenosine; DMSO, dimethylsulfoxide; DPCPX, 8-cyclopentyl-1,3-dipropylxanthine; gp, guinea pig; h, human; m
Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions
Keywords: h، انسان; WT, wild-type; NPY, neuropeptide Y; PYY, peptide YY; PP, pancreatic polypeptide; [125I]pPYY, iodinated porcine PYY; GPCR, G-protein coupled receptor; h, human; p, porcine; TM, transmembrane; hβ2AR, human β2 andrenergic receptor; tβ1AR, turkey β1 andrenerg
The alternatively spliced murine pregnane X receptor isoform, mPXRΔ171–211 exhibits a repressive action
Keywords: h، انسان; PXR, pregnane X receptor; CYP, cytochrome P450; MDR1, Multi Drug Resistance Protein 1; P-gp, P-glycoprotein; TSA, trichostatin A; RXR, retinoid X receptor; NR, nuclear receptors; h, human; m, mouse; mRNA, messenger ribonucleic acid; mP1, mPXR431; mP2, mPX
Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity
Keywords: h، انسان; Gamma-glutamyltranspeptidase; N-terminal nucleophile hydrolase; Thermophilic enzymes; Geobacillus thermodenitrificans; Glutathioneγ-GT, gamma-glutamyl transpeptidase; Hp, Helicobacter pylori; Ec, Escherichia coli; h, human; Gth, Geobacillus thermodenitrif
Comparison of the pharmacological properties of human and rat histamine H3-receptors
Keywords: h، انسان; GPCR, G protein-coupled receptor; GTPγS, guanosine 5′-[γ-thio]triphosphate; h, human; r, rat; β2AR, β2-adrenoceptor; H3R, histamine H3-receptor; H4R, histamine H4-receptor; TM, transmembrane domain; JNJ-7753707, (4-fluorophenyl)(1-methyl-2-an-1H-imidazol-
Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)
Keywords: h، انسان; ANK, ankyrin repeat domain; C-TAD, C-terminal trans-activation domain; FIH-1, factor inhibiting HIF-1; FP, fluorescence polarisation; h, human; HIF, hypoxia-inducible factor; HIF-α, hypoxia-inducible factor α subunit; HIF-P4H, HIF prolyl 4-hydroxylase; OD
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A2A and A3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
Keywords: h، انسان; AR, adenosine receptor; h, human; TM, transmembrane; EL2, second extracellular loop; GPCR, G protein-coupled receptor; SVM, Support Vector Machine; SVR, Support Vector Regression; autoMEP, autocorrelated Molecular Electrostatic Potential; QSAR, quantitati
Keratin Mutation Predisposes to Mouse Liver Fibrosis and Unmasks Differential Effects of the Carbon Tetrachloride and Thioacetamide Models
Keywords: h، انسان; Ab, antibody; CCl4, carbon tetrachloride; h, human; H&E, hematoxylin and eosin; Hsp, heat shock protein; IF, intermediate filament; MMP, matrix metalloproteinase; RT-PCR, reverse-transcription polymerase chain reaction; TAA, thioacetamide; TIMP, tissue in
Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells
Keywords: h، انسان; CICR, Ca2+-induced Ca2+-release; [Ca2+]i, intracellular free calcium concentration; cADPR, cyclic ADP-ribose; ADPR, ADP-ribose; h, human; mhCD38, mutant human CD38; ACh, acetylcholine; mAChR, muscarinic acetylcholine receptors; NG, NG108-15; fura-2 AM, fu
The Endoplasmic Reticulum Ca2+-pump SERCA2b Interacts with G Protein-coupled Receptors and Enhances their Expression at the Cell Surface
Keywords: h، انسان; ER, endoplasmic reticulum; β2AR, β2 adrenergic receptor; δOR, δ opioid receptor; GPCR, G protein-coupled receptor; BFA, brefeldin A; DDM, n-dodecyl-β-D-maltoside; DMEM, Dulbecco's modified Eagle medium; h, human; HEK293, human embryonic kidney 293; LH, lu
Cloning and functional characterization of allelic variation in the porcine prolactin receptor
Keywords: h، انسان; AMV-RT, avian myeloblastosis virus reverse transcriptase; CHO-K1, Chinese hamster ovary K1 cells; ECD, extracellular domain; EF, elongation factor-α1; h, human; hGH, human growth hormone; HRP, horseradish peroxidase; LPG-A, lysosomal membrane glyocoprotei
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist
Keywords: h، انسان; 5-HT1B receptor; SB-616234-A; Human; Rat; Guinea pigCHO, Chinese hamster ovary; GDP, guanosine diphosphate; h, human; MAOI, monoamine oxidase inhibitor; PEI, polyethylenimine; SB-616234-A, 1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1
Expression of recombinant goldfish glutamic acid decarboxylase 65 and evidence for differential pH and PLP responsiveness compared to the human enzyme
Keywords: h، انسان; GAD, glutamic acid decarboxylase; MBP, maltose binding protein; GST, glutathione-S-transferase; gf, goldfish; h, human; PLP, pyridoxal-5′-l-phosphate.GST-fusion; Maltose binding protein fusion; PLP-binding; Recombinant goldfish GAD65; Recombinant human GA
Large-scale preparation and in vitro characterization of biologically active human placental (20 and 22K) and pituitary (20K) growth hormones: Placental growth hormones have no lactogenic activity in humans
Keywords: h، انسان; Human growth hormones; Binding protein; Pituitary; PlacentalCD, circular dichroism; GH, growth hormone; PRL, prolactin; GHR, growth hormone receptor; ECD, extracellular domain; h, human; o, ovine; r, rat; rb, rabbit
Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen
Keywords: h، انسان; human placental lactogen; X-ray crystallography; human prolactin receptor; surface plasmon resonance; alanine-scanningECD, extracellular domain; h, human; hPL, human placental lactogen; hPRL, human prolactin; MAD, multiwavelength anomalous dispersion; MH,
Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments
Keywords: h، انسان; ANCA, anti-neutrophil cytoplasmic antibodies; HMC-1, human mast cell line 1; NE, neutrophil elastase; PR3, proteinase 3; h, human; m, murine; MeO, methoxy; Suc, succinyl; pNa, paranitroanilide; SLPI, secretory leukoprotease inhibitorProteinase 3; Neutroph
MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57
Keywords: h، انسان; MEF2; Ki-1/57; Pressure overload; Heart hypertrophyTAoC, transverse aortic constriction; LV, left ventricle; h, human; r, rat; m, mouse; rMEF2C, MEF2C from rat; YTS, yeast two-hybrid system