Keywords: غلظت موثر نیمه حداکثر; freeze-drying/lyophilization; formulation; protein delivery; mucosal drug delivery; stabilization; solid dosage form; solid state stability; BP; British Pharmacopoeia; CG; carrageenan; EC50; half-maximal effective concentration; FDI; fast-dissolving inser
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Keywords: غلظت موثر نیمه حداکثر; Bronchial epithelial cells; Cigarette smoke; Tobacco vapor; Oxidative stress; Inflammation; In vitro; AqE; aqueous extract; ARE; antioxidant response element; DMEM; Dulbecco's modified Eagle's medium; E-CIGs; e-cigarettes; EC50; half-maximal effective con
Keywords: غلظت موثر نیمه حداکثر; TMV; tobacco mosaic virus; 1H NMR; 1H nuclear magnetic resonance; 13C NMR; 13C nuclear magnetic resonance; HRMS; high-resolution mass spectrometer; EC50; half-maximal effective concentration; MST; microscale thermophoresis; SAR; structure-activity relat
Keywords: غلظت موثر نیمه حداکثر; Benzothiazepine derivatives; Pyridine; 1,3-Dipolar cycloaddition; Antiviral activity; YYRNVXFTRZVMRS-UHFFFAOYSA-N; KIZODVVVLZAAEP-UHFFFAOYSA-N; AMCKYOLBFWMGPW-UHFFFAOYSA-N; RZWVFWUINNLNNM-UHFFFAOYSA-N; ITSYQYKUGUDNGM-UHFFFAOYSA-N; CHCMHFYRPUYOKD-UHFFFAOYS
Keywords: غلظت موثر نیمه حداکثر; DRG; dorsal root ganglion; EC50; half-maximal effective concentration; sEPSC; spontaneous excitatory postsynaptic current; SG; substantia gelatinosa; TRP; transient receptor potential; TTX; tetrodotoxin; VH; holding potential; Thymol; TRPA1; Rat; Spinal d
Keywords: غلظت موثر نیمه حداکثر; EC50; half-maximal effective concentration; 1H NMR; 1H nuclear magnetic resonance; 13C NMR; 13C nuclear magnetic resonance; MS; mass spectroscopy; TMV; tobacco mosaic virus; SAR; structure-activity relationship; 4-Amino-2-methylpyrimidine moiety; 1,3,4-
Keywords: غلظت موثر نیمه حداکثر; Xoo; Xanthomonas oryzae pv. oryzae; Xoc; Xanthomonas oryzae pv. oryzicolaby; EC50; half-maximal effective concentration; 1H NMR; 1H nuclear magnetic resonance; 13C NMR; 13C nuclear magnetic resonance; IR; infrared spectroscopy; SAR; structure-activity r
Keywords: غلظت موثر نیمه حداکثر; CO; competitive inhibitor; [D]; molar concentration of antipsychotics in the extracellular fluid; DAT; dopamine transporter; D2R; dopamine D2 receptor; D2H; high-affinity D2R; D2L; low-affinity D2R; EC50; half-maximal effective concentration; Kd; dissocia
Modulation by orexin A of spontaneous excitatory and inhibitory transmission in adult rat spinal substantia gelatinosa neurons
Keywords: غلظت موثر نیمه حداکثر; Orexin A; Excitatory transmission; Inhibitory transmission; Rat; Spinal dorsal horn; Patch-clamp; EC50; half-maximal effective concentration; sEPSC; spontaneous excitatory postsynaptic current; sIPSC; spontaneous inhibitory postsynaptic current; SG; subst
HCV Genotype 6a Escape From and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models
Keywords: غلظت موثر نیمه حداکثر; DAA; Escape Variants; Nucleotide Analog; In Vitro System; aa; amino acid; DAA; direct-acting antivirals; EC50; half-maximal effective concentration; FFU/mL; focus forming units per milliliter; HCV; hepatitis C virus; NGS; next-generation sequencing; NI;
Using bisphenol A and its analogs to address the feasibility and usefulness of the CALUX-PPARγ assay to identify chemicals with obesogenic potential
Keywords: غلظت موثر نیمه حداکثر; Peroxisome proliferator-activated nuclear hormone receptor γ (PPARγ); CALUX; Obesogens; In vitro screening; Metabolism; Bisphenols; 15dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; 3OH BDE-47; 3-hydroxy BDE-47; 5OH BDE-47; 5-hydroxy BDE-47; BADGE; Bisphenol
Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches
Keywords: غلظت موثر نیمه حداکثر; GPCR; G protein-coupled receptor; EP4; prostaglandin E2 receptor EP4 subtype; LPAR; lysophosphatidic acid receptor; DTI; drug-target interaction; ADE; adverse drug event; MoA; mechanism of action; Ki; inhibition constant; Kd; dissociation constant; IC50;
Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord
Keywords: غلظت موثر نیمه حداکثر; EC50; half-maximal effective concentration; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; sEPSC; spontaneous excitatory postsynaptic current; sIPSC; spontaneous in
Impact of paroxetine on proximal β-adrenergic receptor signaling
Keywords: غلظت موثر نیمه حداکثر; βAR; β-adrenergic receptor; βarr; β-arrestin; EC50; half-maximal effective concentration; FRET; fluorescence resonance energy transfer; GRK; G protein-coupled receptor; IC50; half-maximal inhibitory concentration; ISO; isoproterenol; mCFP; monomeric c
Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
Keywords: غلظت موثر نیمه حداکثر; 2CM-C; 2â²-C-methyl-cytidine; 2â²-F-2â²-C-MeC; 2â²-fluroro-2â²-C-methyl-cytidine (PSI-6130); ACT; 2â²-amino-cytidine triphosphate; EC50; half-maximal effective concentration; GI-GVII; norovirus genogroup designations; GII.4; genogroup II genotype
An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity
Keywords: غلظت موثر نیمه حداکثر; alpha adrenergic receptors; anthracyclines; cardioprotection; catecholamines; heart failure; α1-AR; alpha-1 adrenergic receptor; AKO; alpha-1A adrenergic receptor knockout; ATP; adenosine triphosphate; BP; blood pressure; DOX; doxorubicin; EC50; half-max
Efficacy of Ledipasvir Plus Sofosbuvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2 Infection
Keywords: غلظت موثر نیمه حداکثر; Antiviral agents; Direct-acting antivirals; Polymerase inhibitor; NS5A inhibitor; EC50; half-maximal effective concentration; HCV; hepatitis C virus; LLOQ; lower limit of quantification; RASs; resistance-associated substitutions; SVR; sustained virologica
Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection
Keywords: غلظت موثر نیمه حداکثر; MERS-CoV; Receptor-binding domain; Humanized monoclonal antibody; Protection; Treatment; Lethal infection; CPE; cytopathic effect; EC50; half-maximal effective concentration; hDPP4; human dipeptidyl peptidase 4; MERS-CoV; Middle East respiratory syndrome
Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants
Keywords: غلظت موثر نیمه حداکثر; CTL; cytotoxic CD8+ T cell; DC; dendritic cell; EC50; half-maximal effective concentration; IM; intramuscular; IP-10; interferon γ-induced protein 10; IRF; interferon regulator factor; mDC; myeloid dendritic cell; MPL; monophosphoryl lipid A; PAMP; patho
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity
Keywords: غلظت موثر نیمه حداکثر; ANOVA; analysis of variance; ATF-1; activating transcription factor-1; CCL-2; chemokine ligand 2; CCL-8; chemokine ligand 8; CCL-18; chemokine ligand 18; CCR-1; chemokine receptor 1; CRBN; cereblon; CRE; cAMP responsive element; CREB; cAMP responsive elem
N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses
Keywords: غلظت موثر نیمه حداکثر; Antigen presenting cell; APC; cell culture-derived HCV; HCVcc; Cytotoxic T lymphocyte; CTL; enzyme-linked immunospot assay; ELISPOT; half-maximal effective concentration; EC50; Hepatitis C Virus; HCV; HCV pseudo particles; HCVpp; interleukin; IL; interfer
Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation
Keywords: غلظت موثر نیمه حداکثر; Cholesterol; Triglycerides; Fetal endothelium; Vein reactivity; TCh; total cholesterol; LDL; low density lipoprotein; HDL; high density lipoprotein; vLDL; very low density lipoprotein; CLDS; cross-sectional lipids determination study; LLDS; longitudinal l
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol
Keywords: غلظت موثر نیمه حداکثر; EC; extracellular; EC2; effective concentration at 2% of maximal response; EC50; half-maximal effective concentration; GABAAR; γ-aminobutyric acid type A receptor; GlyR; glycine receptor; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IC; int
Endomorphin-1 analogues (MELs) penetrate the blood-brain barrier and exhibit good analgesic effects with minimal side effects
Keywords: غلظت موثر نیمه حداکثر; Antinociception; Blood-brain barrier; Constipation; Endomorphin; Tolerance; BBB; bloodâbrain barrier; cAMP; cyclic adenosine monophosphate; CCI; chronic constriction injury; CNS; central nervous system; DOR; δ opioid receptor; EM-1; endomorphin-1; EM
L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation
Keywords: غلظت موثر نیمه حداکثر; BAT; Brown adipose tissue; CBP; cAMP responsive element binding protein (CREBP) binding protein; CDK5; Cyclin-dependent kinase 5; EC50; half-maximal effective concentration; FFA; Free fatty acids; HOMA-IR; HOMA of insulin resistance; ITT; Insulin toleranc
Asteraceae species with most prominent bioactivity and their potential applications: A review
Keywords: غلظت موثر نیمه حداکثر; AAPH,2,2'; -azobis(2-methylpropionamidine) dihydrochloride; ABTS; [2,2'-azinobis(3-ethylbenzthiazoline-6-sulphonic acid)]; AUC; area-under-the-curve; BHA; butylated hydroxyanisole; CUPRAC; cupric ion reducing antioxidant capacity; DPPH; 2,2-diphenyl-1
Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4
Keywords: غلظت موثر نیمه حداکثر; Memory T cells; TH1/TH2; T-cell epitope; HLA class II; Can f 4; lipocalin allergen; peptide; allergy; immunotherapy; APC; Antigen-presenting cell; EC50; Half-maximal effective concentration; IC50; Half-maximal inhibitory concentration; PIT; Peptide-based
Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction
Keywords: غلظت موثر نیمه حداکثر; D, Dead; non-binding streptavidin mutant; EC50; half-maximal effective concentration; L3/4; loop connecting β-strands 3 and 4; LH; Love-Hate ligand; rmsd; root mean square deviation; SA; wild-type core streptavidin; SAe; core streptavidin with C-termin
What are the optimal pharmacokinetic properties of antipsychotic medications?
Keywords: غلظت موثر نیمه حداکثر; [D]; molar concentration of antipsychotics in the extracellular fluid; D2R; dopamine D2 receptor; D2H; high-affinity D2R; D2L; low-affinity D2R; EC50; half-maximal effective concentration; Kd; dissociation constant of dopamine for D2R; Ki; dissociation co
Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver
Keywords: غلظت موثر نیمه حداکثر; Growth Factor; Cirrhosis; Mouse Model; Binding Mutant; BrdU; bromodeoxyuridine; EC50; half-maximal effective concentration; FasL; Fas ligand; HGF/SF; hepatocyte growth factor/scatter factor; HSPG; heparan sulfate proteoglycan; PARP; poly(adenosine diphosp
Dynamic, semi-quantitative imaging of intracellular ROS levels and redox status in rat hippocampal neurons
Keywords: غلظت موثر نیمه حداکثر; ACSF; artificial cerebrospinal fluid; AMC; antimycin A; ATZ; 3-amino-1,2,4-triazole; BSO; buthionine sulphoximine; CCD; charge coupled device; CFP; cyan fluorescent protein; CM-H2DCFDA; 5,6-chloromethyl-2´,7´-dichlorodihydrofluorescein diacetate; CNâ;
Oxidative stress induction by (+)-cordiaquinone J triggers both mitochondria-dependent apoptosis and necrosis in leukemia cells
Keywords: غلظت موثر نیمه حداکثر; 7-AAD; 7-amino-actinomycin; AO/EB; acridine orange/ethidium bromide; BrdU; 5-bromo-2â²-deoxyuridine; DCF; dichlorofluorescein; DMSO; dimethyl sulfoxide; Dox; doxorrubicin; EC50; half-maximal effective concentration; FSC; forward light scatter; H2-DCF-DA;
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
Keywords: غلظت موثر نیمه حداکثر; glutamate receptor; stargazin; trafficking; auxiliary subunit; plasticity; electrophysiology; CaMKII; calcium/calmodulin kinase II; EC50; half-maximal effective concentration; ER; endoplasmic reticulum; IKA/IGlu ratio; ratio of kainate- to glutamate-induc