e2f1 gene is a new member of Wnt/β-catenin/Tcf-regulated genes
Keywords: مانع HDAC; E2F repression; HDAC inhibitor; E1A and Ras oncogenes; Wnt/β-catenin/Tcf pathway;
مقالات ISI مانع HDAC (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components
Keywords: مانع HDAC; HDAC inhibitor; Plasmodium falciparum; NSAID; Malaria; Histone
A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells
Keywords: مانع HDAC; HDAC inhibitor; Apoptosis; Colon cancer cells; Chidamide
Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors
Keywords: مانع HDAC; HDAC inhibitor; Fluoroalkene
The epigenetics of social adversity in early life: Implications for mental health outcomes
Keywords: مانع HDAC; DNA methylation; Demethylation; Chromatin; Maternal care; Methionine; TSA; HDAC inhibitor; Mental health; Psychopathology; Human brain; Hippocampus; Neuron; Childhood abuse; Adversity; Suicide; Schizophrenia; Bipolar disorder; Rodent; Gene environment int
Epigenetic therapies for chemoresensitization of epithelial ovarian cancer
Keywords: مانع HDAC; Ovarian cancer; Epigenetics; Chemosensitization; Platinum resistance; DNMTI; HDAC inhibitor
MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis
Keywords: مانع HDAC; experimental autoimmune neuritis; HDAC inhibitor; MS-275; Foxp3+ T cell; M2 macrophageBNB, blood nerve barrier; EAE, experimental autoimmune encephalomyelitis; EAN, experimental autoimmune neuritis; Foxp3, fox head box protein3; HDAC, histone deacetylase;
Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo
Keywords: مانع HDAC; S6 kinase; Acetyltransferase; HDAC inhibitor
Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor
Keywords: مانع HDAC; Leukemia; HDAC inhibitor; JNJ-26481585; Apoptosis; Epigenetic therapy
Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity
Keywords: مانع HDAC; HDAC inhibitor; Acylurea; Hydroxamic acid; SAR; Anticancer; Efficacy;
Identification of Tumor and Invasion Suppressor Gene Modulators in Bladder Cancer by Different Classes of Histone Deacetylase Inhibitors Using Reverse Phase Protein Arrays
Keywords: مانع HDAC; urinary bladder; carcinoma; histone deacetylase inhibitors; genes, suppressor; protein array analysis; DI; concentration interpolation; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; FAK; focal adhesion kinase; HDAC; histone deacetylase; HDACi; HDAC inhib
Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions
Keywords: مانع HDAC; Histone deacetylase; DNA double strand break; HDAC inhibitor; Mechanism of action; Apoptosis; Suberoylanilide hydroxamic acid
Exploiting cellular pathways to develop new treatment strategies for AML
Keywords: مانع HDAC; Acute myeloid leukemia; Flavopiridol; HDAC inhibitor; Targeted therapies; PARP; FLT3
Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons
Keywords: مانع HDAC; in vitro differentiation; ventralization factors; TH; Pitx3; HDAC inhibitor; DA; dopamine; FGF8; fibroblast growth factors; nmNSCs; non mesencephalic neural stem cells; Shh; Sonic Hedgehog; TH; tyrosine hydroxylase; TSA; trichostatin A;
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity
Keywords: مانع HDAC; HDAC; Pancreatic cancer; HDAC inhibitor; Isoform
Suppression of caspase-11 expression by histone deacetylase inhibitors
Keywords: مانع HDAC; HDAC inhibitor; Caspase-11; NF-κB; Inflammation
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity
Keywords: مانع HDAC; HDAC inhibitor; Benzimidazole; Hydroxamic acid; SAR; Anticancer
HDAC inhibitors in models of inflammation-related tumorigenesis
Keywords: مانع HDAC; AOM, azoxymethane; DSS, dextran sulphate sodium; HDAC, histone deacetylase; SAHA, suberoylanilide hydroxamic acid; Th, T helperHDAC; HDAC inhibitor; Inflammation-induced tumorigenesis
Inherited glycosylphosphatidyl inositol deficiency: A treatable CDG
Keywords: مانع HDAC; PIGM; Glycosylphosphatidylinositol deficiency; Thrombosis; Epilepsy; Histone acetylation; HDAC inhibitor
The promises and pitfalls of epigenetic therapies in solid tumours
Keywords: مانع HDAC; Epigenetics; DNMTI; HDAC inhibitor; Pharmacodynamic; Biomarker; Solid tumour
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions
Keywords: مانع HDAC; VPA; HDAC inhibitor; Histone acetylation; BDNF; GABAA receptor; GAD;
Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment
Keywords: مانع HDAC; CBP; cyclic adenosine monophosphate-responsive element-binding protein-binding protein; FHL2; four-and-a-half LIM-domain protein 2; FoxO1; forkhead box class O1; HDAC inhibitor; histone deacetylase inhibitor; PI3-K; phosphatidylinositol 3-kinase; PKB/Akt;
Chemically distinct HDAC inhibitors prevent adipose conversion of subcutaneous human white preadipocytes at an early stage of the differentiation program
Keywords: مانع HDAC; C/EBPα; CCAAT/enhancer-binding protein-α; FABP4/aP2; adipose specific fatty acid binding protein; FCS; foetal calf serum; GPDH; Sn-glycerol-3-phosphate dehydrogenase; HBSS; Hank's balanced salt solution; HDAC; histone deacetylase; HDACi; histone deacety
Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR
Keywords: مانع HDAC; HDAC inhibitor; SAR; Hydroxamic acid
Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors
Keywords: مانع HDAC; Histone deacetylases (HDACs); HDAC inhibitor; Anti-proliferative activity; s-Triazine; Benzamides
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Keywords: مانع HDAC; HDAC inhibitor; Isoform selectivity; HDAC3; Internal cavity; Biaryl; Spirocycle
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Keywords: مانع HDAC; HDAC inhibitor; Isoform selectivity; HDAC3; Internal cavity; Biaryl
Histone deacetylase inhibitor apicidin-mediated drug resistance: Involvement of P-glycoprotein
Keywords: مانع HDAC; Multidrug resistance; P-glycoprotein; HDAC inhibitor; Apicidin; Apoptosis
A homogeneous cellular histone deacetylase assay suitable for compound profiling and robotic screening
Keywords: مانع HDAC; HDAC inhibitor; Cellular HDAC activity; Medium-throughput screening; Assay development
Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents
Keywords: مانع HDAC; Histone deacetylase; HDAC inhibitor; Hydroxamic acids; Anti-tumor
Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid
Keywords: مانع HDAC; Histone deacetylase; HDAC inhibitor; HDACi; SAHA
Benzo[b]thiophene-based histone deacetylase inhibitors
Keywords: مانع HDAC; HDAC; Histone deacetylase inhibitor; HDAC inhibitor; Anticancer drug; SAHA; Hydroxamic acids; Benzo[b]thiophene
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors
Keywords: مانع HDAC; HDAC; HDAC inhibitor; Isoindoklinone; Hydroxamic acid; Pancreatic cancer; p21
Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells
Keywords: مانع HDAC; Chromatin assembly; Histone acetylation; HDAC inhibitor; Transcription; Confocal microscopy; Fluorescence anisotropy; FCS; FRAP; Gene regulation
FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70
Keywords: مانع HDAC; FK228; SAHA; HDAC inhibitor; Hsp90; Hsp70; Acetylation; Chaperone function; Leukemia; Apoptosis
Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor
Keywords: مانع HDAC; Histone deacetylase; HDAC inhibitor; N-Hydroxy-7-(2-naphthylthio) heptanomide; Anti-tumor agent; Cell cycle arrest
The Expanding Role of Epigenetics in the Development, Diagnosis and Treatment of Prostate Cancer and Benign Prostatic Hyperplasia
Keywords: مانع HDAC; prostate; prostatic neoplasms; genetics; DNA methylation; chromatin; 5-AC; 5-aza-cytidine; BPH; benign prostatic hyperplasia; DAC; 5-aza-deoxycytidine; EGCG; (-)-epigallocatechin-3-gallate; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACi;
AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines
Keywords: مانع HDAC; HDACI, histone deacetylase inhibitor; PB, 4-phenylbutyrate; BA, butyric acid; FA, formaldehyde; AN-113, butyroyloxymethyl-4-phenylbutyrate; MG, malignant glioma; DSB, double-strand breaksAN-113; HDAC inhibitor; Glioma; Radiation potentiation; γ-H2AX
Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-κB activation by the HDAC inhibitor apicidin
Keywords: مانع HDAC; Histone deacetylase; HDAC inhibitor; Apicidin; NF-κB; PI3K; PKC
Blockade of the ERK pathway markedly sensitizes tumor cells to HDAC inhibitor-induced cell death
Keywords: مانع HDAC; ERK pathway; MEK inhibitor; HDAC inhibitor; Apoptosis; Reactive oxygen species; Combination therapy
Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene
Keywords: مانع HDAC; ALAS2; Histone acetylation; p300; HDAC inhibitor; Transcription regulation
Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells
Keywords: مانع HDAC; Oncolytic virus; HDAC inhibitor; Adenovirus; CAR; Lung cancer
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors
Keywords: مانع HDAC; HDAC; HDAC inhibitor; Cyclic amide; Class selectivity; Hydroxamic acid
Design and synthesis of phthalimide-type histone deacetylase inhibitors
Keywords: مانع HDAC; Thalidomide; Phthalimide; HDAC inhibitor