دانلود مقالات ISI درباره موسسه علوم بهداشت و محیط زیست + ترجمه فارسی

ایمنی واکسن کمکی: تمرکز بر خود ایمنی

Safety of vaccine adjuvants: Focus on autoimmunity

Keywords: موسسه علوم بهداشت و محیط زیست; AID; autoimmune disorders; AF; adjuvant formulations; ASIA; autoimmune/inflammatory syndrome induced by adjuvants; CFA; complete Freund′s adjuvant; CIA; collagen-induced arthritis; DA; dark Agouti; DC; dendritic cells; EAE; experimental autoimmune encep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

پذیرش مقررات و استفاده از مطالعات سم شناسی باروری یک نسل در اروپا

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe

Keywords: موسسه علوم بهداشت و محیط زیست; ACSA; Agricultural Chemical Safety Assessment of the ILSI HESI; ARA; Actual Regulatory Acceptance by regulatory authorities; CARACAL; Competent Authorities for REACH and GLP; CLP; classification and labelling process; CMR; Carcinogenic, Mutagenic and Repr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

رویکردها و ملاحظات برای ارزیابی ایمنی مسکن برای مواد شیمیایی محیطی: خلاصه کارگاه

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: A workshop summary

Keywords: موسسه علوم بهداشت و محیط زیست; 2,4-D; 2,4-dichlorophenoxyacetic acid; ACD; allergic contact dermatitis; ACSA; agricultural chemical safety assessment; AFC; antibody forming cell; CP; cyclophosphamide; CT; carbon tetrachloride; DART; developmental and reproductive toxicology; DIT; devel

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

چالش های کشف و توسعه داروهای استنشاقی: واکنش ماکروفاژ آلوئولار منجر شده است

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Keywords: موسسه علوم بهداشت و محیط زیست; 3D; Three dimensional; AM; Alveolar macrophage; APSGB; Academy of Pharmaceutical Science of Great Britain; BAL; Bronchoalveolar lavage; CAD; Cationic amphiphillic drugs; COPD; Chronic obstructive pulmonary disease; DLCO; Diffusing capacity of the lung for

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report

Keywords: موسسه علوم بهداشت و محیط زیست; Safety pharmacology; Cardiotoxicity; Human-induced pluripotent stem cell-derived cardiomyocytes; Multi-electrode array technology; APD; action potential duration; APC; automated patch clamp; CiPA; Comprehensive in vitro Proarrhythmia Assay; CSRC; Cardiac

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals

Keywords: موسسه علوم بهداشت و محیط زیست; AOPs; Adverse Outcome Pathways; FSANZ; Food Standards Australia New Zealand; HTE; High Throughput Exposure; HTS; high throughput screening; ILSI; International Life Sciences Institute; HESI; Health and Environmental Sciences Institute; RISK21; Risk Assess

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion

Keywords: موسسه علوم بهداشت و محیط زیست; Comprehensive In-Vitro Proarrhythmia assay; CiPA; hERG; Multiple cardiac ion channels; Proarrhythmia; QTc; Torsade de pointes; AV; atrioventricular; CiPA; Comprehensive In-Vitro Proarrhythmia Assay; CSRC; Cardiac Safety Research Consortium; DG; Discussion

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes

Keywords: موسسه علوم بهداشت و محیط زیست; Arrhythmia; EAD; CardioExcyte 96; Cardiomyocytes; CiPA; Contractility; Extracellular field potential; hiPSC; Impedance; Safety pharmacology; AXG; Cor.4U®, hiPSC-CMs, Ncardia; BrCoV; Beat rate (beat period) coefficient of variation; CDI; iCell Cardiomyocy

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells

Keywords: موسسه علوم بهداشت و محیط زیست; BaP; benzo[a]pyrene; BT; 1,2,4-benzenetriol; 2DC; 2-dimensional hierarchical clustering; DO; disperse orange; HHRA; Human Health Risk Assessment; HESI; Health and Environmental Sciences Institute; MOA; Mode of Action; MN; micronucleus; NSC; Nearest Shrunk

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Computational approaches to understand the adverse drug effect on potassium, sodium and calcium channels for predicting TdP cardiac arrhythmias

Keywords: موسسه علوم بهداشت و محیط زیست; ANN; Artificial Neural Network; CASH; Cardiac Arrest Study Hamburg; CAST; Cardiac Arrhythmia Suppression Trial; Cav1.2; L-Type calcium channel; CiPA; Comprehensive in vitro Proarrhythmic Assay; CSRC; Cardiac Safety Research Consortium; DHPs; 4-Aryl-1,4-di

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Keywords: موسسه علوم بهداشت و محیط زیست; Regulatory toxicology; Transcriptomics; Metabolomics; Good laboratory practice (GLP); Weight-of-evidence (WoE); Adverse outcome pathway (AOP); Mode-of-action (MoA); Gene expression; Differentially expressed genes; ANOVA; Analysis of variance; AOP; Adverse

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress

Keywords: موسسه علوم بهداشت و محیط زیست; APD; action potential duration; AERS; adverse event reporting system; CiPA; Comprehensive in Vitro Proarrhythmia Assay; EAD; early after depolarizations; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; HT; high throughput; hSC-C

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report

Keywords: موسسه علوم بهداشت و محیط زیست; Concordance criteria; Developmental toxicology; Imaging; Micro-CT; Skeletal evaluation; GLP validation; 2-D; two-dimensional; 3-D; three-dimensional; CRO; contract research organization; DART; developmental and reproductive toxicology; EFD; embryo-fetal d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach

Keywords: موسسه علوم بهداشت و محیط زیست; Immunotoxicology; Immunotoxicity; Immunomodulation; Immunosuppression; Carcinogenicity; Cancer; Risk assessment; CTL; cytotoxic T-lymphocytes; EBV; Epstein-Barr virus; FDA; Food and Drug Administration; HESI; Health and Environmental Sciences Institute;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

Keywords: موسسه علوم بهداشت و محیط زیست; Comprehensive in vitro Proarrhythmia Assay (CiPA); Field potential data sampling and analysis; Induced pluripotent cell cardiomyocytes (hiPSC-CMs); Multi electrode array (MEA); Patch clamp technologies; Pending issues and solutions; Validation; Voltage se

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

A public-private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Keywords: موسسه علوم بهداشت و محیط زیست; ADRs; adverse drug reactions; CDER; Center for Drug Evaluation and Research; cTn; cardiac troponin; CV; cardiovascular; EMA; European Medicines Agency; EWG; Expert Working Group; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; h

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

La prévision des effets indésirables des médicaments par des études non cliniques est-elle performante ?

Keywords: موسسه علوم بهداشت و محیط زیست; Médicaments; Effets indésirables; Toxicité; Drugs; Adverse event; Toxicity; E.ME.A.; European Medicines Agency; H.E.S.I.; Health and Environmental Sciences Institute; I.C.H.International Conference on Harmonization; I.L.S.I.International Life Sciences

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه