کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8533838 | 1560472 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report
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کلمات کلیدی
EADhiPSC-CMsFDATQTcSrcCIPATorsade de pointesMEATDPAPDDADHERGFPDAPCmulti-electrode array - آرایه چند الکترودهایComprehensive in vitro Proarrhythmia Assay - آزمون جامع در معرض پرواریتریماSafety pharmacology - داروی ایمنیFood and Drug Administration - سازمان غذا و داروCardiotoxicity - سمیت قلبیAction potential duration - مدت زمان بالقوه عملfield potential duration - مدت زمان بالقوه میدانICH - منHealth and Environmental Sciences Institute - موسسه علوم بهداشت و محیط زیستHESI - ها Marchesihuman ether-à-go-go-related gene - ژن وابسته به اتر-أ-go-go انسان استInternational Conference of Harmonization - کنفرانس بین المللی هماهنگیAutomated patch clamp - گیره پچ خودکار
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Safety pharmacology studies that evaluate drug candidates for potential cardiovascular liabilities remain a critical component of drug development. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have recently emerged as a new and promising tool for preclinical hazard identification and risk assessment of drugs. Recently, Pluriomics organized its first User Meeting entitled 'Combining Pluricyte® Cardiomyocytes & MEA for Safety Pharmacology applications', consisting of scientific sessions and live demonstrations, which provided the opportunity to discuss the application of hiPSC-CMs (Pluricyte® Cardiomyocytes) in cardiac safety assessment to support early decision making in safety pharmacology. This report summarizes the outline and outcome of this Pluriomics User Meeting, which took place on November 24-25, 2016 in Leiden (The Netherlands). To reflect the content of the communications presented at this meeting we have cited key scientific articles and reviews.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological and Toxicological Methods - Volume 91, MayâJune 2018, Pages 36-42
Journal: Journal of Pharmacological and Toxicological Methods - Volume 91, MayâJune 2018, Pages 36-42
نویسندگان
Petra Mulder, Tessa de Korte, Elena Dragicevic, Udo Kraushaar, Richard Printemps, Maria L.H. Vlaming, Stefan R. Braam, Jean-Pierre Valentin,