Keywords: ASK1; apoptosis signal-regulating kinase 1; ASK2; apoptosis signal-regulating kinase 2; DMSO; dimethyl sulphoxide; hERG; human ether-a-go-go-related gene; JNK; c-Jun N-terminal kinase; MKK7; mitogen activated kinase kinase 7; MTT; 3-(4,5-dimethylthiazol-2
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: arrhythmia; genome editing; induced pluripotent stem cells; long QT syndrome; variant of uncertain significance; AP; action potential; APD; action potential duration; Cas9; CRISPR-associated protein 9; CRISPR; clustered regularly interspaced short palindr
Keywords: AV; atrioventricular; CSI; cardiosomatic index; CAT; catalase; CS; citrate synthase; d.m.; dry mass; EDV; end-diastolic volume; EF1α; elongation factor 1α; ESV; end-systolic volume; fH; contractile rate; GPX1a; glutathione peroxidase 1a; GST-pi; glutath
Keywords: Channelopathy; Animal venom; Peptide toxin; Disease; Ligand-receptor interaction; Drug seeds; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; BK channel; big potassium channel; CFA; Freund's complete adjuvant; CFTR; cystic fibrosis transmembr
Keywords: Type 2 diabetes; Glucokinase; Glucokinase activator; Thiophenyl-pyrrolidine scaffold; hERG; Zwitterion;
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; AUC; area under the curve; BnSH; benzyl mercaptan; Xantphos; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3
Keywords: Integral membrane proteins; Molecular dynamics simulations; Protein-ligand interactions; Markov State Models; Kinetic cell models; AP; action potential; EM; electron microscopy; HH; Hodgkin and Huxley model; hERG; human ether-a-go-go channel; HCN; hyperpo
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3A4; DSC; differential scanning calorimetry; DIBAL-H; diisobutylaluminium hydride; DME; 1,2-dimethoxyethane; DM
Keywords: 5HT3R; 5-hydroxytryptamine receptor, subtype 3; ATP; Adenosine triphosphate; BK; big potassium channels; Cho; cholesterol; CTD; C-terminal domain; ECD; extracellular domain; ELIC; Erwinia chrysanthemi ligand-gated ion channel; GABAAR; gamma-aminobutyric a
Keywords: MD; Molecular dynamics; QM; quantum mechanics; human Ether-a-go-go-Related Gene; hERG; VS; voltage-sensing domain; Voltage-gated ion channel modulation; Membrane dipole potential; hERG activators; Ion channel activators; Molecular dynamics;
Keywords: 3-BC; 3-benzylidene camphor; 4-MBC; 4-methylbenzylidene camphor; Aβ; amyloid-β; ABAD; Aβ-binding alcohol dehydrogenase; AD; Alzheimer's disease; AI; aromatase inhibitor; AKR; aldo-keto reductase; AME; apparent mineralocorticoid excess; AR; androgen r
Keywords: [Ca++]i; intracellular Ca2+ concentration; 2ME2; 2-methoxyestradiol, a natural metabolite of estradiol; 4-OH-Tmx; 4-hydroxytamoxifen, a metabolite of Tmx; 5-HT3R; 5-hydroxytryptamine receptor subtype 3; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropio
Keywords: Gating; hERG; KCNA5; KCNE1; KCNQ1; Pharmacology; Potassium channel;
Keywords: STX; Saxitoxin; PST; Paralytic Shellfish Toxin; PSP; paralytic shellfish poisoning; VGSC; voltage-gated-sodium channel; GTX; Gonyautoxins; EFSA; European Food Safety Authority; hERG; human ether-a-go-go; TTX; Tetrodotoxin; LPS; lipopolysacharride; SOD; su
Keywords: CYP2C19; cytochrome P450 C19; CYP2C9; cytochrome P450 C9; CYP3A4; cytochrome P450 3A4; HERG; human ether-Ã -go-go-related gene; HPLC; high-pressure liquid chromatography; IKr; rapid component of delayed rectifier potassium current; IKur; ultrarapid acti
Keywords: Arrhythmia; Combination therapy; hERG; Kv11; Kv12; Leukemia; Nanoparticles; Side effects; Tumor;
Keywords: Channelopathies; Long QT syndrome; Short QT syndrome; Brugada syndrome; Catecholaminergic polymorphic ventricular tachycardia; Sudden cardiac death; ATS; Anderson-Tawil syndrome; AP-A; anthopleurin-A; APD; action potential duration; BrS; Brugada syndrom
Keywords: BK; big potassium channel; BN-PAGE; blue native polyacrylamide gel electrophoresis; Cav; voltage-gated calcium; CNG; cyclic nucleotide-gated channels; CRAC; cholesterol binding sites; CTD; cytoplasmic domain; ENaC; epithelial sodium channels; FRET; Först
Keywords: Sodium channel blocker; Ischemic stroke; Neuroprotection; hERG; Pyrrolidine;
Keywords: Adsorption; Formulation analysis; hERG; Purkinje; Solubility; Stability;
Keywords: DFO; Desferoxamine; DTNB; 5,5 dithio-bis-nitrobenzoic acid; DTNBi; intracellular DTNB; DTNBe; extracellular DTNB; DTT; dithiothreitol; GSH; glutathione; GSHi; intracellular glutathione; GSHe; extracellular glutathione; H2O2; hydrogen peroxide; HERG; human
Keywords: ADC; antibody-drug conjugate; ADME; absorption, distribution, metabolism and elimination; EFD; embryofetal development; ELISA; enzyme-linked immunosorbent assay; FIH; first-in-human; GLP; Good Laboratory Practice; hERG; human ether-Ã -go-go related gene;
Keywords: CVGP; anesthetized cardiovascular guinea pig; Cu; free plasma concentration; GP; guinea pig; hCav1.2; human L-type calcium current; hERG; human ether-a-go-go related gene; hNav1.5; human cardiac Na + channel α-subunit; IKr; rapidly activating delayed re
Keywords: AP; action potential; APD; AP duration; ATX-II; anemonia sulcata toxin 2; DMSO; dimethylsulfoxide; ECG; electrocardiogram; eSC; embryonic stem cell; FP; field potential; FPD; FP duration; HEK; human embryonic kidney; hERG; human ether-a-go-go-related gene
Keywords: 3Rs; replacement, refinement and reduction of animals in research; ACSA; Agricultural Chemicals Safety Assessment; ADA; anti-drug antibody; CNS; central nervous system; DBS; dried blood spot; DART; developmental and reproductive toxicity; DRF; dose range
Keywords: APD90; action potential duration at 90% repolarization; BDM; 2,3-butanedione monoxime; BTS; N-benzyl-p-toluene sulphonamide; Cav1.2; calcium channel produced from the CACNA1C gene; cTnI; cardiac troponin I; C-E curve; concentration-effect curve; Cx43; con
Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)
Keywords: Ion channel; Fsp3; Bicyclic molecule; hERG; NaV1.5;
Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel
Keywords: Loperamide; N-Desmethyl loperamide; hERG; KvLQT1; mink; Nav1.5; QT prolongation; QRS prolongation; Cryo-EM docking; ZMOPTLXEYOVARP-UHFFFAOYSA-N; RDOIQAHITMMDAJ-UHFFFAOYSA-N;
Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report
Keywords: Safety pharmacology; Cardiotoxicity; Human-induced pluripotent stem cell-derived cardiomyocytes; Multi-electrode array technology; APD; action potential duration; APC; automated patch clamp; CiPA; Comprehensive in vitro Proarrhythmia Assay; CSRC; Cardiac
Effects of norquetiapine, the active metabolite of quetiapine, on cloned hERG potassium channels
Keywords: Quetiapine; Norquetiapine; hERG; Activated state block;
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate
Keywords: Salicylamine; Metabolism; Toxicity; Human; Rat; Rabbit; γKA; γ-ketoaldehyde; 2-AA; 2-aminoanthracene; 2-HOBA; 2-hydroxybenzylamine; 4-NOPD; 4-nitro-o-phenylenediamine; CYP; cytochrome p450; hERG; human ether-a-go-go; HPLC; high-performance liquid chroma
Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623
Keywords: Heart; Action potential; Potassium ion channels; Transient outward current; hERG; KChIP2; DPP6; NS3623;
Restoration of mutant hERG stability by inhibition of HDAC6
Keywords: hERG; HDAC6; Acetylation; Ubiquitination; LQT2;
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo
Keywords: DHE; dehydroevodiamine; IKr; rapid delayed rectifier current; APD; action potential duration; EAD; early afterdepolarization; cAVB; chronic atrioventricular block; TdP; Torsade de Pointes arrhythmia; hiPSC-CM; human induced pluripotent stem cell-derived c
In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices
Keywords: AUC; Area Under the Curve; CRO; Contract Research Organization; CTA; Clinical Trial Authorization; GLP; Good Laboratory Practice; hERG; human ether-a-go-go-related gene; ICH; International Conference on Harmonization; IND; Investigational New Drug; IQ; In
Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay
Keywords: Human stem cell cardiomyocytes; Calcium fluorescent dye; Calcium transient; Preclinical cardiac safety; Amp; amplitude; bpm; beats per minute; BR; beat rate; CiPA; Comprehensive in Vitro Proarrhythmia Assay; CTD; calcium transient duration; DMSO; dimethyl
New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV
Keywords: Bacterial gyrase; Topoisomerase IV; Drug resistance; Binding sites; Potency; DNA; deoxyribonucleic acid; ATP; adenosine triphosphate; GyrA; gyrase A subunit; GyrB; gyrase B subunit; ParC; topoisomerase IV C subunit; ParE; topoisomerase IV E subunit; PDB;
Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis
Keywords: Sudden infant death syndrome; Genotype-phenotype correlation; Long QT syndrome; hERG; Channel gating;
Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target
Keywords: Kv10.1; hEAG1; hERG; Ion channel; Epilepsy;
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
Keywords: Oxime; Sodium-dependent glucose co-transporter; Aryl C-glycosides; Diabetes management; Ac2O; acetic anhydride; AMG; α-methyl-d-glucopyranoside; BF3·OEt2; boron trifluoride etherate; CHO; Chinese hamster ovary; DMAP; 4-N,N-dimethylaminopyridine; hERG; h
Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics
Keywords: ADH; alcohol dehydrogenase; CDC; Centers for Disease Control and Prevention; CYP; cytochrome P450; del; deletion; EDDP; 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine; EM; extensive metabolizer; EMDP; 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline; FDA; Food and
CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion
Keywords: Comprehensive In-Vitro Proarrhythmia assay; CiPA; hERG; Multiple cardiac ion channels; Proarrhythmia; QTc; Torsade de pointes; AV; atrioventricular; CiPA; Comprehensive In-Vitro Proarrhythmia Assay; CSRC; Cardiac Safety Research Consortium; DG; Discussion
Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search
Keywords: NS3623 (PubChem CID: 9954236); NS1643 (PubChem CID: 10177784); PD-307243 (PubChem CID: 54440733); A-935142 (PubChem CID: 25125452); azimilide (PubChem CID: 9571004); ICA-105574 (PubChem CID: 715924); KB130015 (PubChem CID: 9872203); PD 118057 (PubChem CID
Voltage gated ion channels blockade is the underlying mechanism of BIMU8 induced cardiotoxicity
Keywords: BIMU8; Cardiac ion channel blockade; hERG; NaV1.5; CaV1.2;
Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2
Keywords: Lobelane; Fluoroethoxy piperidine and piperazine analogs; VMAT2; Dopamine uptake; hERG;
Ion currents of cardiomyocytes in different regions of the Göttingen minipig heart
Keywords: Cardiac electrophysiology; Delayed rectifier K+ channel; Göttingen minipig; Inward rectifier K+ channel; L-type Ca2Â + channel; Patch clamp; hERG; Ion channel; Heart;
Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators
Keywords: HEK293 cells; human embryonic kidney 293 cells; hERG; human ether-Ã -go-go-related gene; IC50; 50% inhibiting concentration; Emax; maximum efficacy; Flavonoids; Quercetin; Fisetin; hERG currents;
Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells
Keywords: Pilsicainide; hERG; Chemical chaperone;
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores
Keywords: hERG; ROMK; Hypertension; Heart failure; Diuresis; Natriuresis; Spirocycle;