دانلود مقالات ISI درباره Herg + ترجمه فارسی

Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration

Keywords: Melanoma; Cancer; HERG; Potassium channels;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of recombinant hERG K+ channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Keywords: Amiodarone; Antiarrhythmic; Class III; Desethyl-amiodarone; hERG; human ether-à-go-go-related gene; IKr; QT interval; Potassium channel;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652

Keywords: Capsaicin; hERG; K+ channel; Voltage clamp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation of cardiac ERG1 K+ channels by cGMP signaling

Keywords: hERG; cGMP; APD; IKr; ANP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

Keywords: Action potential; hERG; Ion channel; Methods; Purkinje fiber; Repolarization; Stem cell; Ventricular; Cardiomyocyte; Torsade de pointes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Cognitive, Behavioral, and Systems NeuroscienceResearch PaperSpontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice

Keywords: oscillation; sympathetic nervous system; serotonin; spontaneous activity; gap junctions; GABA; aCSF; artificial cerebrospinal fluid; Cx36; connexin 36; GABA; gamma amino butyric acid; Hb9; homeobox gene 9; HERG; human Ether-a-go-go Related Gene; mRNA; mes

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 °C: Cisapride versus dofetilide

Keywords: Action potential; Cisapride; Dofetilide; hERG; Methods; QT interval; Torsades de points; Screening

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Structural determinants for histamine H1 affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs

Keywords: Antihistamine; Terfenadine; Astemizole; Torsades de pointes; hERG; H1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Hypoxia inhibits maturation and trafficking of hERG K+ channel protein: Role of Hsp90 and ROS

Keywords: hERG; Hypoxia; Chaperones; Hsp90; ROS; Low temperatures

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

2,4-Diaminopyridine δ-opioid receptor agonists and their associated hERG pharmacology

Keywords: 2,4-Diaminopyridine; Delta opioid receptor; Agonist; Library chemistry; hERG

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design

Keywords: PC-1 inhibitor; hERG; Homology model

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors—Part II

Keywords: 5-HT1A/1B/1D antagonists; Serotonin reuptake inhibitors; 5-HT1 autoreceptors; hERG; Antidepressant

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach

Keywords: NOP/ORL1 agonist; Antinociception; hERG; Pharmacophore

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Effect of compound plate composition on measurement of hERG current IC50 using PatchXpress

Keywords: cLogP; Compound plate adsorption; HEK293; hERG; PatchXpress; Incubation time

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Test article concentrations in the hERG assay: Losses through the perfusion, solubility and stability

Keywords: hERG; Dose solution analysis; Preclinical methods; Purkinje; Solubility; Stability

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Keywords: PYK2; FAK; Kinase; Osteoporosis; hERG; Sulfoximine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Biophysical properties of zebrafish ether-à-go-go related gene potassium channels

Keywords: zERG; hERG; Potassium channel; Delayed rectifier; Repolarization; Arrhythmia; Animal model

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Rapid component IKr of cardiac delayed rectifier potassium currents in guinea-pig is inhibited by α1-adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways

Keywords: hERG; human ether-a-go-go related gene; PKA; protein kinase A; PKC; protein kinase C; PE; phenylephrine; 5-MU; 5-methylurapidil; Adrenergic receptor; Phenylephrine; Arrhythmia; Potassium channel; PKA; PKC;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

Keywords: Channelopathy; hERG; hERG1a/1b; hERG1b; QT interval; Rapid delayed rectifier; Short QT syndrome;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: The case of hERG K+ channel blockers

Keywords: 3D-QSAR; ALMOND; hERG; GRIND; Molecular modellingCoMFA, comparative molecular field analysis; GRIND, grid independent descriptors; hERG, human ether-à-go-go related gene; LV, latent variable; MIF, molecular interaction fields; PLS, partial least squares;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Aminoglycoside antibiotics restore functional expression of truncated HERG channels produced by nonsense mutations

Keywords: Long QT syndrome; HERG; Nonsense mutation; Aminoglycoside antibiotics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

Keywords: Arrhythmia; Long QT Syndrome; rho GAP; HERG; Potassium current; Ion channel; Protein trafficking

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Keywords: hERG; Allosteric; Akt; Kinase

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative

Keywords: APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (IKs) potassium channels

Keywords: Tanshinone IIA; hKCNQ1/hKCNE1; IKs; Kv1.5; hERG; IK1; HEK 293 cell; Potassium channel; Ion channel; Patch clamp; Human

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Quantitative structure–activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities

Keywords: QSAR; Depression; 5HT2A; SERT; HERG; Conformation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A2A antagonists with reduced hERG liability

Keywords: A2A antagonists; Adenosine receptor; Parkinson’s disease; Phenacylaminopyrimidines; hERG

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

Keywords: Cathepsin S inhibitor; Brain-penetrating; hERG; Multiple sclerosis; Neuropathic pain

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

1-Aminoindanes as novel motif with potential atypical antipsychotic properties

Keywords: Atypical antipsychotic; D2 antagonism; 5HT antagonism; hERG; Indane

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG

Keywords: Atrioventricular block; hERG; QT prolongation; Zebrafish; Methods

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein

Keywords: hERG; Hypoxia; Mitochondria; ROS; NADPH oxidase; Mitochondrial reactive oxygen species; Proteasome

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Functional studies on three novel HCNH2 mutations in Taiwan: Identification of distinct mechanisms of channel defect and dissociation between glycosylation defect and assembly defect

Keywords: Potassium channel; HERG; Long QT syndrome; Voltage clamp; Glycosylation; Trafficking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

If a drug deemed 'safe' in nonclinical tests subsequently prolongs QT in phase 1 studies, how can its sponsor convince regulators to allow development to proceed?

Keywords: CHMP; Committee for Medicinal Products for Human Use; COX; Cycloxygenase; ECG; Electrocardiogram; EU; European Union; FDA; Food and Drug Administration of the United States; hERG; Human ether-a-go-go related gene; ICH; International Conference on Harmoniz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo

Keywords: RNA interference; herg; SH-SY5Y cell; Tumor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis

Keywords: APD; action potential duration; ECG; electrocardiogram; hERG; human ether-a-gogo related gene; MAP; monophasic action potential; QTc; corrected QT interval on ECG; TdP; torsade de pointes; VT; ventricular tachycardia; VF; ventricular fibrillation; TRIaD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: Compound effects of hERG pore region mutation and SCN5A N-terminus variant

Keywords: Congenital long QT syndrome; Atrioventricular block; Ventricular tachycardia; SCN5A; hERG; Mutation; Variant; Lidocaine

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

Keywords: Long QT syndrome; Sudden cardiac death; Electrophysiology; HERG; Nonsense-mediated decay;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

Keywords: Torsades-de-Pointes; QT; Preclinical studies; hERG; Proarrhythmia model; Delayed repolarization

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Model systems for the discovery and development of antiarrhythmic drugs

Keywords: Arrhythmias; Ion channel blockers; Ion currents; Reentry; AF; atrial fibrillation; APD; action potential duration; CAVB; chronic atrio-ventricular block; CHF; congestive heart failure; DAD; delayed afterdepolarization; EAD; early afterdepolarization; hERG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

A binary QSAR model for classification of hERG potassium channel blockers

Keywords: hERG; Potassium channel; Binary QSAR; VSA descriptors; GH score

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Regulation of cardiac excitation and contraction by p21 activated kinase-1

Keywords: Protein phosphatase 2A; L-type Ca2+-channel; Sarcomeric protein phosphorylation; Ryanodine receptor; AC; denylate cyclase; Ad; adenovirus; BK channel; Ca2+-activated K+ currents; B(PR55); PP2A regulatory subunits; B′(PR61); PP2A regulatory subunits; Bâ€

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Molecular aspects of the congenital and acquired Long QT Syndrome: Clinical implications

Keywords: Ion channel; Long QT Syndrome; Arrhythmia; Sudden cardiac death; hERG; KCNQ1; SCN5A; KCNE1; KCNE2; CACNA1c; KCNJ2; Genotype; Phenotype; Congenital; Acquired; Torsade de pointes

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model

Keywords: hERG; Methods; Proarrhythmia; QT prolongation; Safety margin; SCREENIT rabbit isolated heart model; Torsades de Pointes; TRIad

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

FRET with multiply labeled HERG K+ channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains

Keywords: HERG; Potassium channel; Cytoplasmic domain architecture; FRET;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2008 سفارش ترجمه

Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists—Increasing selectivity over hERG

Keywords: Melanin-concentrating hormone; MCH-R1 antagonists; Obesity; hERG; QTc prolongation; Aminomethyl tetrahydronaphthalene ketopiperazines

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Discovery of novel and orally active NR2B-selective N-methyl-d-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity

Keywords: HERG; NMDA; NR2B; Pain; Solubility

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

Keywords: Serotonin reuptake; Noradrenaline reuptake; Metabolic stability; hERG; SNRI

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists

Keywords: 5-HT6 antagonist; Benzoxazine; Brain penetration; hERG; Lipophilicity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Reduction of hERG potassium currents by hyperosmolar solutions

Keywords: Patch-clamp technique; Human ether-a-go-go related gene; hERG; CHO cells; d-mannitol; Hyperosmolar solution

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain

Keywords: NMDA; NR2B antagonist; PK variability; CYP2D6; HERG

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه