Rapid access towards follow-up NOP receptor agonists using a knowledge based approach

A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement of the benzimidazol-2-one moiety was explored. Compound 51 was found to be a high affinity, potent NOP receptor agonist with reduced affinity for the hERG channel.

A knowledge based approach was applied to explore novel NOP receptor agonists with simplified hydrophobes. Compound 51 was identified as a high affinity, potent NOP receptor agonist.Figure optionsDownload as PowerPoint slide