دانلود مقالات ISI درباره Herg + ترجمه فارسی

Data ArticleData on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression

Keywords: hERG; Recombinant cell line; hERG mRNA expression; hERG protein expression;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores

Keywords: hERG; ROMK; Hypertension; Heart failure; Diuresis; Natriuresis; Spirocycle;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Atrial fibrillation: Therapeutic potential of atrial K+ channel blockers

Keywords: ACh; acetylcholine; AF; atrial fibrillation; AP; action potential; APD; action potential duration; cIK,ACh; consitutively active IK,ACh; GIRK; G protein-coupled inwardly-rectifying potassium channel; hERG; human ether-a-go-go related gene channels; IC50;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Measuring kinetics and potency of hERG block for CiPA

Keywords: aLQTS; acquired long QT syndrome; CiPA; Comprehensive in vitro Proarrhythmic Assay; hERG; human ether-a-go-go related gene; AP; action potential; ICWG; Ion Channel Working Group; ISWG; In Silico Working Group; CTWG; Clinical Translation Working Group; SPS

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition

Keywords: Boc; tert-butoxycarbonyl; Pd(OAc)2; palladium acetate; PBu3; tributylphosphine; DIBAL-H; diisobutylaluminum hydride; S-phos; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; Pd2(dba)3; tris(dibenzylideneacetone) dipalladium; NaH; sodium hydride; LiAlH

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and neuroprotective effects of Fenazinel derivatives

Keywords: Fenazinel; Synthesis; hERG; Neuroprotective; Ischemic stroke;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose

Keywords: hERG; Caffeine; 17β-estradiol; Cardiac toxicity; Cardiac electrophysiology;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative

Keywords: Action potential (AP); Action potential duration (APD); Cardiac voltage-gated ion channels; INa; Ito; IK1; hERG; IKs; In-vitro study; Cardiac action potential; Early afterdepolarization (EAD); Delayed afterdepolarization (DAD); Cardiac arrhythmias; QT pro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity

Keywords: CiPA; Torsade de pointes; Acquired long QT; Clinical risk prediction; KV11.1; Cisapride; Bepridil; Loperamide; hERG; QT interval;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Keywords: AcOEt; ethyl acetate; chloramine-T; N-chloro 4-methylbenzenesulfonamide sodium salt; DMAP; N,N-4-dimethylaminopyridine; DMF; N,N-dimethylformamide; hERG; human Ether-a-go-go Related Gene; HOBt; 1-hydroxybenzotriazole; IBX; o-iodoxybenzoic acid; LDA; lithi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

The KCNH2-IVS9-28A/G mutation causes aberrant isoform expression and hERG trafficking defect in cardiomyocytes derived from patients affected by Long QT Syndrome type 2

Keywords: Long QT Syndrome; Induced pluripotent stem cells; Cardiomyocytes; hERG; Trafficking; Splicing;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Attenuation of ischemia/reperfusion-induced inhibition of the rapid component of delayed rectifier potassium current by Isosteviol through scavenging reactive oxygen species

Keywords: I/R; ischemia/reperfusion; ROS; reactive oxygen species; IKr; rapid component of delayed rectifier potassium; APD; action potential duration; ECG; electrocardiogram; STVNa; Isosteviol sodium; Ito; transient outward potassium channel current; ISS; steady-s

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Computational approaches to understand the adverse drug effect on potassium, sodium and calcium channels for predicting TdP cardiac arrhythmias

Keywords: ANN; Artificial Neural Network; CASH; Cardiac Arrest Study Hamburg; CAST; Cardiac Arrhythmia Suppression Trial; Cav1.2; L-Type calcium channel; CiPA; Comprehensive in vitro Proarrhythmic Assay; CSRC; Cardiac Safety Research Consortium; DHPs; 4-Aryl-1,4-di

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

3D-SDAR modeling of hERG potassium channel affinity: A case study in model design and toxicophore identification

Keywords: 3D-QSDAR; hERG; Toxicophore; Modeling; Potassium channel;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

Keywords: SSTR5; somatostatin receptor subtype 5; OGTT; oral glucose tolerance test; hERG; human ether-a-go-go related gene; DM; diabetes mellitus; HFD; high-fat diet; NCS; N-chlorosuccinimide; WSC; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride; HOB

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2017 سفارش ترجمه

Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core

Keywords: EML4-ALK kinase; Oxidative metabolism; Benzo[b]carbazolone; hERG; Antitumor activity;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Finding a Needle in a QT Interval Big Data Haystack

Keywords: adverse drug reactions; electronic health records; FAERS; HERG; long QT syndrome;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG

Keywords: B-Raf; B-Raf inhibitor; hERG

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation

Keywords: hERG; ROMK; Hypertension; Heart failure; Diuresis; Natriuresis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

Keywords: CiPA; hERG; Kv11.1; Markov model; Methods; Temperature;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

Keywords: Somatostatin receptor subtype 3; Antagonist; Tetrahydro-β-carboline; hERG; SAR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

Keywords: AP; cardiac action potential; CiPA; comprehensive in vitro proarrhythmia assay; CSRC; Cardiac Safety Research Consortium; Cmax; maximal plasma concentration; CTWG; clinical translational working group; DRest; rate-normalized Tpeak − Tend = Tpe inter

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular pathogenesis of long QT syndrome type 2

Keywords: Long QT syndrome; Ion channel; Trafficking; KCNH2; hERG;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Thaliporphine, an alkaloid from Neolitsea konishii, exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease

Keywords: Thaliporphine; Cardiovascular; Reactive oxygen species; QT interval; Apoptosis; Inflammatory; Lipopolysaccharide (PubChem CID: 11970143); Thaliporphine (PubChem CID: 100020); Triphenyltetrazolium chloride (PubChem CID: 9283); 1400W hydrochloride (PubChem

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Keywords: LQTS; long QT syndrome; HERG; human-ether-a-go-go-related gene; HS; heat shock; HSP; heat shock protein; HSF; heat shock factor; GGA; geranyl geranyl acetone; Long QT syndrome; Human ether-a-go-go-related gene; Heat shock factor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

Keywords: hERG; ROMK; Hypertension; Heart failure; Diuresis; Natriuresis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

Keywords: data mining; data science; drug-drug interaction; long QT syndrome; APD70; action potential duration at 70% of repolarization; DDI; drug-drug interaction; ECG; electrocardiogram; EHR; electronic health records; FAERS; Food and Drug Administration adverse

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data

Keywords: AIC; Akaike information criterion; BSV; between subject variability; BLQ; below the limit of quantification; CV; cardiovascular; ECG; electrocardiogram; hERG; human ether-a-go-go-related gene channel; hCav1.2; human cardiac calcium channel; hNav1.5; human

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Keywords: AF; atrial fibrillation; diLQTS; drug induced long QT syndrome; DEA; desethylamiodarone; HEK; human embryonic kidney; hERG; human-Ether-à-go-go-Related Gene; IC50; half-maximal inhibitory concentration; IhERG; ionic current carried by hERG potassium chan

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities

Keywords: Anticancer activity; Benzothiazole; Urea; Amide; Pyridylamide; B-RafV600E; C-Raf; ATCC; American tissue culture collection; CDI; 1,1'-carbonyldiimidazole; CLogP; Calculated LogP (Partition coefficient); DIPEA; N,N-diisopropylethylamine; DTT; Dithiothreito

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS

Keywords: Acquired long QT syndrome; Kinetics; Kv11.1; Arrhythmia; Simulation; hERG; IKr; rapid delayed rectifier potassium current; AP; action potential; APD90; action potential duration at 90% maximal repolarisation; IKr50; 50% reduction in conductance of the rap

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2016 سفارش ترجمه

Mitragynine and its potential blocking effects on specific cardiac potassium channels

Keywords: Mitragynine; Cardiotoxicity; hERG; GIRK; Kir2.1;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2016 سفارش ترجمه

Use of molecular modeling aided design to dial out hERG liability in adenosine A2A receptor antagonists

Keywords: Adenosine A2A receptor; hERG; MK-499; Docking; Superposition; Transformation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The enhancement of cardiac toxicity by concomitant administration of Berberine and macrolides

Keywords: hERG; Cytochrome P450 (CYP); Berberine (BBR); Azithromycin (AZM); Clarithromycin (CLR); Cardiac toxicity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: Insights from a receptor model

Keywords: CCR3; Chemokine; Piperidine-4-yl-1H-indoles; Rodent selectivity; hERG; Receptor model;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Rare Incidence of Ventricular Tachycardia and Torsades de Pointes in Hospitalized Patients With Prolonged QT Who Later Received Levofloxacin: A Retrospective Study

Keywords: ECG; electrocardiogram; HERG; human-a-go-go-ether-related gene; QTc; corrected QT interval;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportEffects of donepezil on hERG potassium channels

Keywords: hERG; Donepezil; Alzheimer׳s disease; Channel trafficking;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Lack of effect of perampanel on QT interval duration: Results from a thorough QT analysis and pooled partial seizure Phase III clinical trials

Keywords: AE; adverse event; AED; antiepileptic drug; ANOVA; analysis of variance; AUC; area under the concentration-time curve; BMI; body mass index; CI; confidence interval; Cmax; maximum plasma concentration; ECG; electrocardiogram; hERG; human ether-à-go-go-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential — A safety approach

Keywords: Berberine (PubChem CID: 2353); Chelerythrine (PubChem CID: 2703); Chelidonine (PubChem CID: 10147); Sanguinarine (PubChem CID: 5154); Coptisine (PubChem CID: 72322)Chelidonium majus; Greater celandine; hERG; Cardiac action potential; Arrhythmia; QT interv

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

QT interval correction assessment in the anesthetized guinea pig

Keywords: ANES GP; anesthetized guinea pig; BP; blood pressure; BT; body temperature; GP; guinea pig; hERG; human ether-a-go-go related gene; IKr; rapidly-activating delayed rectifier potassium current; IKs; slowly-activating delayed rectifier potassium current; MA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Computational investigations of hERG channel blockers: New insights and current predictive models

Keywords: hERG; TdP; Arrhythmia; QSAR; Computational approaches; Ligand-based; Structure based, Polymorphism;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Sialic acids attached to N- and O-glycans within the Nav1.4 D1S5-S6 linker contribute to channel gating

Keywords: VGICs; voltage-gated ion channels; AP; action potentials; Nav; voltage-gated Na+ channels; CHO; Chinese Hamster Ovary; Kv; voltage-gated K+ channel; hSkM1; human adult skeletal muscle voltage-gated Nav channel, Nav1.4; Nav1.4/1.5DIS5-6; Nav1.4 chimera i

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Exploring the gyrase ATPase domain for tailoring newer anti-tubercular drugs: Hit to lead optimization of a novel class of thiazole inhibitors

Keywords: Mycobacterium tuberculosis; Gyrase ATPase domain; Medium throughput screening; hERG; Tuberculosis

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors

Keywords: HCV; NS5A inhibitor; Benzidine; Diaminofluorene; Structure-activity relationship; HCV; hepatitis C virus; Peg-IFNα; pegylated interferon α; SVR; sustained virological response; GT1a; hepatitis C virus genotype 1a, a subtype of hepatitis C virus genoty

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Keywords: Flecainide; hERG; QT interval; Repolarization; Torsades de Pointes;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2015 سفارش ترجمه

M3 muscarinic acetylcholine receptor in cardiology and oncology

Keywords: Arrhythmias; Cardio-oncology; EGFR; HERG; Ischemia; M3-muscarinic receptor (M3-mAChR);

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Widened QRS interval and left ventricular systolic depression after propafenone and promazine exposure

Keywords: Cardiac arrhythmias; HERG; Propafenone; Promazine; Drug-drug interaction;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

HERG-targeted therapy in both cancer and cardiovascular system with cardiovascular drugs

Keywords: Cancer chemotherapy; Cardio-oncology; Cardiotoxicity; HERG; Multidrug resistance (MDR); Torsade de pointes arrhythmia(TdP);

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors

Keywords: 5-HT; serotonin; NE; norepinephrine; DA; dopamine; SSRI; selective serotonin reuptake inhibitor; SNRI; serotonin norepinephrine reuptake inhibitor; TRI; triple reuptake inhibitor; CYP; cytochrome P450; hERG; human ether-a go-go-related gene; HEK; human em

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker

Keywords: T-type calcium channel blocker; hERG; L-type calcium channel; Pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه