Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 23, 1 December 2016, Pages 5695-5702

Yuping Zhu, Reynalda K. de Jesus, Haifeng Tang, Shawn P. Walsh, Jinlong Jiang, Xin Gu, Nardos Teumelsan, Aurash Shahripour, Barbara Pio, Fa-Xiang Ding, Sookhee Ha, Birgit T. Priest, Andrew M. Swensen, Magdalena Alonso-Galicia, John P. Felix,