دانلود مقالات ISI درباره HEK، کلیه جنین انسان + ترجمه فارسی

The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function

Keywords: HEK، کلیه جنین انسان; 7-CK, 7-chlorokynurenic acid; AP5, d,l-2-amino-5-phosphonopentanoic acid; CIAP, calf intestinal alkaline phosphatase; GFP, green fluorescent protein; HEK, human embryonic kidney; HEPES, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid; IK, somatic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis

Keywords: HEK، کلیه جنین انسان; HERG, human ether-a-go-go-related gene; HEK, human embryonic kidney; PKA, protein kinase A; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; CPT-cAMP, chlorophenylthiol-cyclic-AMP; H89, N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline; Bis-I,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Drug transport by Organic Anion Transporters (OATs)

Keywords: HEK، کلیه جنین انسان; ACE, angiotensin converting enzyme; BCL6, B-cell CLL/lymphoma 6; DDI, drug–drug interaction; DHEAS, dehydroepiandrosterone sulfate; ES, estrone-3-sulfate; HEK, human embryonic kidney; HNF, hepatocyte nuclear factor; HUGO, human genome organization; Jmax,

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2012 سفارش ترجمه

Agonist ligand discrimination by the two orexin receptors depends on the expression system

Keywords: HEK، کلیه جنین انسان; A11,dL15-orexin-B, Ala11,d-Leu15-orexin-B; CHO, Chinese hamster ovary; GPCR, G-protein-coupled receptor; GFP, green fluorescent protein; HBM, Hepes-buffered medium; HEK, human embryonic kidney; probenecid, p-(dipropylsulfamoyl) benzoic acidOrexin; Hypocre

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes

Keywords: HEK، کلیه جنین انسان; ANP, atrial natriuretic peptide; BNP, B-type or brain natriuretic peptide; CNP, C-type natriuretic peptide; HEK, human embryonic kidney; HF, heart failure; NT, N-terminal; FBS, fetal bovine serum; Ben-gal, benzyl 2-acetamido-2-deoxy-sll-α-d-galactopyranos

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex

Keywords: HEK، کلیه جنین انسان; PKD, polycystic kidney disease; HEK, human embryonic kidney; TRP, transient receptor potential; TM, transmembraneSour taste receptor; Calcium permeation; Channel pore; Point mutation; Polycystic kidney disease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

Keywords: HEK، کلیه جنین انسان; BMCC-biotin, 1-Biotinamido-4-(4′-[maleimidoethyl-cyclohexane]-carboxamido) butane; GPCRs, G-protein coupled receptors; HA, hydroxylamine; HEK, human embryonic kidney; mRFP, monomeric red fluorescent protein; NEM, N-ethyl maleimide; RRS, Ras recruitment sy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Structure–function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor

Keywords: HEK، کلیه جنین انسان; AM, adrenomedullin; CGRP, calcitonin gene-related peptide; C-tail, cytoplasmic C-terminal tail; CLR, calcitonin receptor-like receptor; GPCR, G protein-coupled receptor; GRK, GPCR kinase; h, human; HEK, human embryonic kidney; Hyg, hygromycin; RAMP, recep

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation

Keywords: HEK، کلیه جنین انسان; APP, acute-phase proteins; CEBPB, CCAAT/enhancer-binding protein beta; HEK, human embryonic kidney; IFN, interferon; IRAK, interleukin-1 receptor-associated kinase; LRR, leucine-rich repeats; MyD88, myeloid differentiation primary response gene/protein 88

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes

Keywords: HEK، کلیه جنین انسان; NPY, neuropeptide Y; PYY, peptide YY; PP, pancreatic polypeptide; GPCR, G protein-coupled receptor; wt, wild type; h, human; p, porcine; PCR, polymerase chain reaction; GFP, green fluorescent protein; HEK, human embryonic kidney; PBS, phosphate-buffered s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles

Keywords: HEK، کلیه جنین انسان; Polysaccharides; Poly(I:C); Nanoparticles; Targeted delivery system; TLR; ImmunogenicityAFM, Atomic Force Microscopy; BMDC, Bone marrow derived dendritic cell; HEK, Human embryonic kidney; NOD, Nucleotide-binding oligomerization domain; ODN, Oligodeoxynuc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε

Keywords: HEK، کلیه جنین انسان; PKC, protein kinase C; ADAM, A Disintegrin and Metalloprotease; PDBu, Phorbol-12-13-dibutyrate; PAGE, polyacrylamide gel electrophoresis; ECL, enhanced chemiluminescence; HEK, human embryonic kidney; DN, dominant negative; CA, constitutively active; RD, r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins

Keywords: HEK، کلیه جنین انسان; CBB, Coomassie Brilliant Blue; CNBr, cyanogen bromide; DG, diacylglycerol; DGK, diacylglycerol kinase; FBS, fetal bovine serum; GFP, green fluorescent protein; GST, glutathione S-transferase; HA, hemagglutinin; HEK, human embryonic kidney; IB, immunoblott

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of distinct c-terminal domains of the Bombyx adipokinetic hormone receptor that are essential for receptor export, phosphorylation and internalization

Keywords: HEK، کلیه جنین انسان; AKH, adipokinetic hormone; AKHR, adipokinetic hormone receptor; GPCR, G protein-coupled receptor; EGFP, enhanced green fluorescent protein; HEK, human embryonic kidney; GRK, G protein-coupled receptor kinase; ERK1/2, extracellular signal-regulated kinase1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

LEDGF/p75 TATA-Less Promoter Is Driven by the Transcription Factor Sp1

Keywords: HEK، کلیه جنین انسان; LEDGF/p75, lens epithelium-derived growth factor or p75; HIV, human immunodeficiency virus; NCBI, National Center for Biotechnology Information; PSIP1, PC4 and SFRS1 interacting protein 1; TSS, transcription start site; HEK, human embryonic kidney; 5′ RLM

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists

Keywords: HEK، کلیه جنین انسان; AR, adenosine receptor; CGS21680, 2-[p-(2-carboxyethyl)phenylethylamino]-5′-N-ethylcarboxamido-adenosine; CHO, Chinese hamster ovary; HEK, human embryonic kidney; SCH 442416, 5-amino-7-(3-(4-methoxy)phenylpropyl)-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein

Keywords: HEK، کلیه جنین انسان; DP-1, E2F dimerization partner 1; RT-PCR, reverse transcription-polymerase chain reaction; HEK, human embryonic kidney; piPSCs, protein-induced pluripotent stem cells; HA, hemagglutinin; DBD, DNA-binding domain; ER, estrogen receptor; WT, wild typeProtein

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of an intracellular microdomain of the P2X7 receptor that is crucial in basolateral membrane targeting in epithelial cells

Keywords: HEK، کلیه جنین انسان; P2X7; Polarized epithelial cell; Basolateral domain targetingMDCK, Madin-Darby canine kidney epithelial cells; LLC-PK1, porcine kidney epithelial cells; HEK, human embryonic kidney; DMEM, Dulbecco’s modified Eagle’s medium; eGFP, enhanced green fluorescen

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner

Keywords: HEK، کلیه جنین انسان; C/EBP, CCAAT/enhancer binding protein; GFP, green fluorescent protein; GST, glutathione-S-transferase; HEK, human embryonic kidney; MDCK, Madin-Darby canine kidney cells; PDZ, postsynaptic density95-discs large-zonula occludens; TAZ, transcriptional coact

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy

Keywords: HEK، کلیه جنین انسان; AGRP, agouti-related protein; BMI, body mass index; CAT, chloramphenicol-acetyl-transferase; CRE, cAMP responsive element; HEK, human embryonic kidney; MC4R, melanocortin-4 receptor; NDP-α-MSH, [Nle4-D-Phe7]-α-MSH; RSV, Rous sarcoma virus; TMH, transmembr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes

Keywords: HEK، کلیه جنین انسان; DPP4, dipeptidyl peptidase inhibitor 4; GLP-1, glucagon-like peptide-1; GPR119, G-protein-coupled receptor 119; GSIS, glucose-stimulated insulin secretion; HbA1c, hemoglobin A1c; HEK, human embryonic kidney; LPC, lysophosphatidylcholine; OEA, oleoylethano

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Screening of human gene promoter activities using transfected-cell arrays

Keywords: HEK، کلیه جنین انسان; A, adenosine; bp, base pair(s); C, cytidine; CAGE, cap analysis gene expression; DAPI, 4`,6-diamidino-2`-phenylindole dihydrochloride; DMEM, Dulbecco’s modified Eagle’s medium; EST, expressed sequence tag; G, guanosine; HEK, human embryonic kidney; IFN, i

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-d-aspartate receptor channels into mitochondria

Keywords: HEK، کلیه جنین انسان; AM, acetoxymethyl; AP-5, 2-amino-5-phosphonovaleric acid; CNS, central nervous system; DMEM, Dulbecco's modified Eagle's medium; EV, empty vector; FBS, fetal bovine serum; GFP, green fluorescent protein; Glu, glutamate; HEK, human embryonic kidney; iGluR,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacological characterisation of the GlyT-1 glycine transporter using two novel radioligands

Keywords: HEK، کلیه جنین انسان; Glycine transporter; GlyT-1; Radioligand binding; Rat brain; Human brainGlyT-1, glycine transporter type 1; hGlyT-1, recombinant human GlyT-1; NMDA, N-methyl-d-aspartate; HEK, human embryonic kidney; HEPES, N-2-Hydroxyethylpiperazine-N′-2-Ethanesulfonic A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1

Keywords: HEK، کلیه جنین انسان; OATP, organic anion transporting polypeptide; BSP, sulphobromophthalein; HEK, human embryonic kidney; IC50, concentration with 50% inhibition; Ki, inhibitory constant; SLCO, solute carrier organic anion transporter; VC, vector controlOrganic anion transpo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Gα16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling

Keywords: HEK، کلیه جنین انسان; Akt, protein kinase B; GPCR, G protein-coupled receptors; GTPase, GTP hydrolyase; HEK, human embryonic kidney; PI3K, phosphatidylinositol 3-kinase; PIP3, Phosphatidylinositol 3,4,5-trisphosphate; PLCβ, phospholipase CβG protein; Gα16; Phosphatidylinositol

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2

Keywords: HEK، کلیه جنین انسان; BS3, bis-(sulfosuccinimidyl)-suberate; CRD, cysteine rich domain; DISC, death inducing signaling complex; FADD, Fas-associating protein with death domain; FasL, Fas ligand; HEK, human embryonic kidney; KD, dissociation constant; mAb, monoclonal antibody;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells

Keywords: HEK، کلیه جنین انسان; 4-HNE, 4-hydroxynonenal; A2E, diretinoid pyridinium ethanolamine; HEK, human embryonic kidney; HRP, horseradish peroxidase; LCA, Leber congenital amaurosis; NADPH, nicotinamide adenine dinucleotide phosphate, reduced form; ONH, optic nerve head; ONL, oute

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Agonist-dependent μ-opioid receptor signaling can lead to heterologous desensitization

Keywords: HEK، کلیه جنین انسان; MOR, μ-opioid receptor; GPCR, G-protein-coupled-receptor; GRKs, G-protein coupled receptor kinases; βArrs, β-arrestins; [Ca2+]i, intracellular Ca2+; DAMGO, [d-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin; HEK, human embryonic kidney; HA, hemagglutinin; PTX, pertu

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Influence of the Cytoplasmic Domains of Aquaporin-4 on Water Conduction and Array Formation

Keywords: HEK، کلیه جنین انسان; AQP, aquaporin; PKC, protein kinase C; 3D, three-dimensional; 2D, two-dimensional; LPR, lipid-to-protein ratio; HEK, human embryonic kidney; FFR, freeze fracture replica; hAQP1, human AQP1water channel; electron crystallography; water permeability; phosph

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors

Keywords: HEK، کلیه جنین انسان; Structure–property–activity relationship model; Lipid rafts; 5-HT3 receptor; Antidepressant drugs; Antipsychotic drugs; Size-intensive descriptors5-HT, serotonin; CNS, central nervous system; HEK, human embryonic kidney; LOO, leave-one-out; μ, molecular d

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Inhibition of 11β-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines

Keywords: HEK، کلیه جنین انسان; 11β-HSD, 11β-hydroxysteroid dehydrogenase; CBX, carbenoxolone; DMEM, Dulbecco's Modified Eagle's Medium; FBS, fetal bovine serum; GR, glucocorticoid receptor; HEK, human embryonic kidney; H6PDH, hexose-6-phosphate dehydrogenaseDiabetes; Glucocorticoid rec

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation

Keywords: HEK، کلیه جنین انسان; Aza, 5-Aza-2-deoxycytidine; HEK, human embryonic kidney; mbtps2, membrane-bound transcription factor protease site 2; PCR, polymerase chain reaction; REX1, reduced expression 1; YY, Yin YangYin Yang 1 (YY1); Yin Yang 2 (YY2); Membrane-bound transcription

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

Keywords: HEK، کلیه جنین انسان; FRET, Förster resonance energy transfer; BRET, bioluminescence resonance energy transfer; GRK, G protein receptor kinase; HEK, human embryonic kidney; Rluc8, Renilla luciferase 8; C, cerulean; V, venusFRET; BRET; Pleckstrin homology domain; Collision; Dif

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Field-effect devices for detecting cellular signals

Keywords: HEK، کلیه جنین انسان; CHO, Chinese hamster ovary; CMOS, complementary metal-oxide semiconductor; EIS, electrolyte–insulator–semiconductor; FED, field-effect device; FET, field-effect transistor; HEK, human embryonic kidney; ISFET, ion-sensitive field-effect transistor; LAPS, l

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1

Keywords: HEK، کلیه جنین انسان; bp, base pairs; CAGE, cap analysis of gene expression; DPE, downstream promoter element; DMEM, Dulbecco's modified Eagle's medium; FANTOM, Functional Annotation of the Mammalian Genome; HEK, human embryonic kidney; Inr, initiator element; MEM, minimal ess

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2

Keywords: HEK، کلیه جنین انسان; cisplatin, Cis-diamminedichloroplatinum II; hOCT, human organic cation transporter; rOCT, rat organic cation transporter; hMATE, human multidrug and toxin extrusion; rMATE, rat multidrug and toxin extrusion; HEK, human embryonic kidney; ICP-MS, inductivel

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

Keywords: HEK، کلیه جنین انسان; CHO cells, Chinese hamster ovary cells; FCS, foetal calf serum; FITC, fluorescein isothiocyanate; HEK, human embryonic kidney; InsP3, inositol 1,4,5-trisphosphate receptor; MCD, methyl-β-cyclodextrin; PBS, phosphate buffered saline; PTX, pertussis toxin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells

Keywords: HEK، کلیه جنین انسان; AP, action potential; APD90, duration of action potential at 90% repolarization; DMEM, Dulbecco's modified Eagle's medium; HEK, human embryonic kidney; I–V, current–voltage; ICa,L, L-type Ca2+ current; IK(DR), delayed-rectifier K+ current; INa, voltage-ga

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions

Keywords: HEK، کلیه جنین انسان; LEC, lymphatic endothelial cell; BEC, blood vascular endothelial cell; CHO, Chinese hamster ovary; HEK, human embryonic kidney; ECM, extracellular matrixPodoplanin; Galectin-8; Lymphatic endothelial cell; Lymphangiogenesis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Generating antibodies against the native form of the human prion protein (hPrP) in wild-type animals: A comparison between DNA and protein immunizations

Keywords: HEK، کلیه جنین انسان; AchE, acetylcholinesterase-EC 3.1.1.7; cDNA, complementary DNA; BC, block copolymer; ET, electrotransfer; GPI, glycosylphosphatidylinositol; HEK, human embryonic kidney; IFA, incomplete Freund's adjuvant; IPTG, isopropyl-β-D-thiogalactopyranose; LB, Luria

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα16 and inhibits the canonical phospholipase Cβ pathway

Keywords: HEK، کلیه جنین انسان; ERK, extracellular signal-regulated kinase; GPCR, G protein-coupled receptors; GTPase, GTP hydrolyase; HEK, human embryonic kidney; MAPK, mitogen-activating protein kinase; NFkB, nuclear factor κB; PLCβ, phospholipase Cβ; SRE, serum response element; SRF,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene

Keywords: HEK، کلیه جنین انسان; 5-aza-dC, 5-aza-2'-deoxycytidine; CRC, colorectal cancer; CT, threshold cycle; DMEM, Dulbecco’s modified Eagle medium; EST, Expressed sequence tags; GC, gastric cancer; GH, growth hormone; HEK, human embryonic kidney; IL-2, interleukin-2; IR, insulin rece

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: Evidence for clinically significant IKr-IKs α-subunit interaction

Keywords: HEK، کلیه جنین انسان; Long QT syndrome; KCNQ1; KCNH2; Torsades de pointes; Sudden cardiac deathAU, arbitrary units; CHO, Chinese hamster ovary; dn, dominant negative; ER, endoplasmic reticulum; E1, KCNE1; HEK, human embryonic kidney; H2, KCNH2; LQTS, long QT syndrome; OD, opti

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK

Keywords: HEK، کلیه جنین انسان; LPA, lysophosphatidic acid; GPCR, G protein-coupled receptor; GRK, G protein-coupled receptor kinase; HEK, human embryonic kidney; PTX, 293 cells, pertussis toxin; MEFs, mouse embryonic fibroblasts; IP3, inositol 1,4,5-trisphosphate; ARF, ADPribosylation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Zonisamide block of cloned human T-type voltage-gated calcium channels

Keywords: HEK، کلیه جنین انسان; AED, antiepileptic drug; CAI, carbonic anhydrase inhibitor; FBS, fetal bovine serum; HEK, human embryonic kidney; LTCS, low-threshold calcium spike; LVA, low-voltage activated; VGCC, voltage-gated calcium channel; VGSC, voltage-gated sodium channel; ZNS,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway

Keywords: HEK، کلیه جنین انسان; KSR, kinase suppressor of Ras; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; MEK, MAPK/ERK kinase; MAP3K, MAPK kinase kinase; HEK, human embryonic kidney; TNF-α, tumor necrosis factor-α; HSP, heat shock protein; TPL-2

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

The Critical Role of Hinge-Region Expulsion in the Induced-Fit Heparin Binding Mechanism of Antithrombin

Keywords: HEK، کلیه جنین انسان; AT, antithrombin; RCL, reactive centre loop; PEG, polyethylene glycol; SI, stoichiometry of inhibition; HEK, human embryonic kidney; EBNA, Epstein–Barr nuclear antigen 1; H5, heparin pentasaccharideallosteric; antithrombin; heparin; pentasaccharide; serpi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in Cardiovascular Safety Research

Keywords: HEK، کلیه جنین انسان; CHO, Chinese Hamster Ovary; DAD, delayed after depolarisations; EAD, early after depolarisations; FEAB, Fentanyl/Etomidate-Anaesthetised Beagle; HEK, Human Embryonic Kidney; hERG, human ether-a-go-go-related gene; HP-β-CD, hydroxypropyl-beta-cyclodextrin;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Expression of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 3 proteins in two major conformational states in native human cell membranes

Keywords: HEK، کلیه جنین انسان; SERCA, sarco/endoplasmic reticulum Ca2+ ATPase; E2 and E1, nonphosphorylated forms of Ca2+ ATPase; Tg, thapsigargin; tBHQ, 2,5-di-tert-butyl-1,4-benzohydroquinone; HEK, human embryonic kidney; ETF, Early Tryptic fragmentation; LTF, Late Tryptic fragmentat

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه