کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1931725 | 1050561 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein](/preview/png/1931725.png)
چکیده انگلیسی
We previously reported the identification of DP-1 isoforms (α and β), which are structurally C-terminus-deleted ones, and revealed the low-level expression of these isoforms. It is known that wild-type DP-1 is degraded by the ubiquitin–proteasome system, but few details are known about the domains concerned with the protein stability/instability for the proteolysis of these DP-1 isoforms. Here we identified the domains responsible for the stability/instability of DP-1. Especially, the DP-1 “Stabilon” domain was a C-terminal acidic motif and was quite important for DP-1 stability. Moreover, we propose that this DP-1 Stabilon may be useful for the stability of other nuclear proteins when fused to them.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 397, Issue 2, 25 June 2010, Pages 345–349
Journal: Biochemical and Biophysical Research Communications - Volume 397, Issue 2, 25 June 2010, Pages 345–349
نویسندگان
Takashi Arakawa, Yoshikazu Masuhiro, Yoshiaki Kamiya, Hirohisa Kojima, Shigemasa Hanazawa,