Keywords: HEK، کلیه جنین انسان; ACE, affinity capillary electrophoresis; AT, antithrombin; BGE, background electrolyte; CE, capillary electrophoresis; DE-ACE, dynamic equilibrium-ACE; EOF, electroosmotic flow; FA, frontal analysis; HEK, human embryonic kidney; K, binding constant; Kd, d
مقالات ISI HEK، کلیه جنین انسان (ترجمه نشده)
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Keywords: HEK، کلیه جنین انسان; Corin; Cytoplasmic tail; Intracellular trafficking; Natriuretic peptides; Transmembrane proteasesFBS, fetal bovine serum; HEK, human embryonic kidney; TTSP, type II transmembrane serine protease; WT, wild-type
Keywords: HEK، کلیه جنین انسان; AG, acyl glucuronide; dKF, dansylated Lys-Phe; DMSO, dimethyl sulfoxide; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HEK, human embryonic kidney; hPBMC, human peripheral blood mononuclear cell; HPLC, high-performance liquid chromatography; IL-1α, int
Keywords: HEK، کلیه جنین انسان; DRG, dorsal root ganglia; HEK, human embryonic kidney; CaCCs, Ca2+-activated Cl– channels; TA, tannic acid; BK, bradykininTannic acid; M/Kv7 K+ currents; CaCCs; Voltage-gated Na+ currents; Bradykinin; Pain
Keywords: HEK، کلیه جنین انسان; BRET, bioluminescence resonance energy transfer; CHO, Chinese hamster ovary; Cre-Luc, cyclic AMP response element-luciferase; GPCRs, G protein-coupled receptors; HEK, human embryonic kidney; KS, Kallmann syndrome; PK2, prokineticin 2; PKR2, prokineticin r
Keywords: HEK، کلیه جنین انسان; CHO, Chinese hamster ovary; DEAE, diethylamino ethanol; FVIIa, activated factor VII; FVIII, factor VIII; FIX, factor IX; FXI, factor XI; HEK, human embryonic kidney; HS, heat sterilized; NHP, natural human plasma; PCR, polymerase chain reaction; QAE, quat
Keywords: HEK، کلیه جنین انسان; PSCs, pluripotent stem cells; hESCs, human embryonic stem cells; iPSCs, induced pluripotent stem cells; HEK, human embryonic kidney; SMA, spinal muscular atrophy; SMN, survival motor neuron; ALS, amyotrophic lateral sclerosisEmbryonic stem cells; Induced
Keywords: HEK، کلیه جنین انسان; DMSO, Dimethylsulphoxide; HEK, Human embryonic kidney; KCa1.1 channel, Large-conductance Ca2+ activated potassium channel; KCl, Potassium chloride; KH, Krebs–Henseleit; PCR, Polymerase-chain-reaction; PGF2α, Prostaglandin F2α; TAS2R, Taste-sensing type 2
Keywords: HEK، کلیه جنین انسان; AChE, acetylcholinesterase; CNS, central nervous system; DMSO, dimethyl sulfoxide; DRG, dorsal root ganglion; EC50, effective concentration for producing half-maximal response; EK, equilibrium potential for K+; HEK, human embryonic kidney; IPSC, inhibitor
Keywords: HEK، کلیه جنین انسان; EGTA, ethylene glycol tetra-acetic acid; WT, wild-type; NOE, Nuclear Overhauser Effect; I-EGF, Integrin-Epidermal Growth Factor; HEK, Human Embryonic Kidney; Asp, Aspartic Acid; Gly, Glycine.Mutation; Integrin activation; Ligand binding; NMR; Conformation
Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action
Keywords: HEK، کلیه جنین انسان; AI, Analgesic Index; COX, Cyclooxygenase; FP, Ficus Platyphylla; HEK, Human Embryonic Kidney; HTP, Hot Plate Nociceptive Threshold; 5-LO, 5-Lipoxygenase; DOR, δ Opiod Receptor; KOR, κ Opioid Receptor; MOR, µ Opioid Receptor; sal, Saline; TPT, Hot-Plate Th
BacMam production of active recombinant lecithin–cholesterol acyltransferase: Expression, purification and characterization
Keywords: HEK، کلیه جنین انسان; LCAT, lecithin–cholesterol acyltransferase; HDL, high density lipoprotein; RCT, reverse cholesterol transport; FC, free cholesterol; CE, cholesteryl ester; CHD, coronary heart disease; HEK, human embryonic kidney; GlcNAc, N-acetyl glucosamine; MANN, manno
MicroRNA-506-3p regulates neural stem cell proliferation and differentiation through targeting TCF3
Keywords: HEK، کلیه جنین انسان; NSCs, neural stem cells; miRNAs, microRNAs; siRNA, interfering RNA; ESC, embryonic stem cell; HEK, human embryonic kidney; GFAP, glial fibrillary acidic protein; Tuj1, Neuronal Class III β-TubulinNeural stem cell; TCF3; MicroRNA-506-3p
Cloning and characterization of two duplicated interleukin-17A/F2 genes in common carp (Cyprinus carpio L.): Transcripts expression and bioactivity of recombinant IL-17A/F2
Keywords: HEK، کلیه جنین انسان; IL-17A/F2; Common carp (Cyprinus carpio); Proinflammatory and innate immune function; Duplicated genes; Expression; Promoter activityAMPs, antimicrobial peptides; FSGD, fish-specific genome duplication; HEK, human embryonic kidney; IL-17A/F2, interleukin-
Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice
Keywords: HEK، کلیه جنین انسان; Myenteric Neurons; Palmitate; Gut Microbiota; LPS; TLR4; Colon TransitFITC, fluorescein isothiocyanate; HEK, human embryonic kidney; HFD, high-fat diet; IM-PEN, immortal postnatal enteric neuronal; JNK, c-Jun N-terminal kinase; LCM, laser capture microdis
Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells
Keywords: HEK، کلیه جنین انسان; AD, Alzheimer’s disease; Aβ, amyloid-β peptide; ADAM, a disintegrin and metalloprotease; AICD, APP intracellular domain; BACE1, beta-site APP cleaving enzyme 1; EDTA, ethylenediaminetetraacetic acid; FBS, fetal bovine serum; HEK, human embryonic kidney; H
Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury)
Keywords: HEK، کلیه جنین انسان; ACD, allergic contact dermatitis; DC, dendritic cell(s); DMSO, dimethylsulphoxide; FACS, fluorescence-activated cell sorting applied; FeCl3, iron(III) chloride; HEK, human embryonic kidney; GM-CSF, granulocyte-macrophage colony stimulating factor; HgCl2,
Thermal stability of purified and reconstituted CFTR in a locked open channel conformation
Keywords: HEK، کلیه جنین انسان; CFTR, cystic fibrosis transmembrane conductance regulator; ABC, ATP-binding cassette; NBD1, N-terminal nucleotide-binding domain; CF, cystic fibrosis; CHO, Chinese hamster ovary; HEK, human embryonic kidney; BHK, baby hamster kidney; Tm, melting temperatu
Cloning and characterization of the proximal promoter region of rainbow trout (Oncorhynchus mykiss) interleukin-6 gene
Keywords: HEK، کلیه جنین انسان; Cytokines; IL6; Luciferase reporter assay; NF-κB p50; TeleostAa, amino acids; CEBP, CCAAT/enhancer-binding protein; CREB, cAMP response element-binding protein; GFP, green fluorescent protein; HEK, human embryonic kidney; LUC, luciferase; MCS, multiple cl
Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition
Keywords: HEK، کلیه جنین انسان; NTCP, sodium taurocholate cotransporting polypeptide; ASBT, apical sodium dependent bile acid transporter; HEK, human embryonic kidney; WST, water soluble tetrazolium; SCUT, Clinician’s Pocket Drug Reference; DILI, drug induced liver injurySodium taurocho
Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation +
Keywords: HEK، کلیه جنین انسان; ONS, oxidative/nitrosative stress; TLR, toll-like receptor; HEK, human embryonic kidney; MD, myeloid of differentiation; CD, cluster of differentiation; pAb, polyclonal antibody; LPS-EK (Ultrapure), lipopolysaccharide from E. coli K12; TLR4-KO macrophages
Functional neuropeptidomics in invertebrates
Keywords: HEK، کلیه جنین انسان; CE, Capillary electrophoresis; CHO, Chinese hamster ovary; CNS, Central nervous system; DiLeu, N,N-dimethyl leucine; dsRed, Red fluorescent protein; GFP, Green fluorescent protein; GPCRs, G-protein coupled receptors; HEK, Human embryonic kidney; IMS, Imag
Biological properties of adrenomedullin conjugated with polyethylene glycol
Keywords: HEK، کلیه جنین انسان; AM, adrenomedullin; PEG, polyethylene glycol; Boc, t-butyloxycarbonyl; HEK, human embryonic kidney; CLR, calcitonin receptor-like receptor; RAMP, receptor activity-modifying proteinAdrenomedullin; Polyethylene glycol; Molecular modification
A missense mutation in the sodium channel β1b subunit reveals SCN1B as a susceptibility gene underlying long QT syndrome
Keywords: HEK، کلیه جنین انسان; AF, atrial fibrillation; APD, action potential duration; APD90, action potential duration at 90% of repolarization; BrS, Brugada syndrome; cDNA, complementary DNA; ECG, electrocardiogram; GFP, green fluorescent protein; HEK, human embryonic kidney; INa, s
Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis
Keywords: HEK، کلیه جنین انسان; BGP, Brazilian green propolis; FBS, fetal bovine serum; HEK, human embryonic kidney; LBD, ligand binding domain; LXR, liver X receptor; NR, nuclear receptor; PPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; RXR, retinoid X re
Dynamics of apelin receptor/G protein coupling in living cells
Keywords: HEK، کلیه جنین انسان; GPCR, G protein-coupled receptor; APJ, apelin receptor; HEK, human embryonic kidney; BRET, bioluminescence resonance energy transfer; FRET, Förster resonance energy transfer; Rluc, Renilla reniformis luciferase; YFP, yellow fluorescent protein; CFP, cyan
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats
Keywords: HEK، کلیه جنین انسان; ABT-639, (4-chloro-2-fluro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide); DRG, dorsal root ganglion; HEK, human embryonic kidney; CCI, chronic constriction injury; SNL, spinal nerve ligation; MAP, mean art
Novel alkylphospholipid-DTC hybrids as promising agents against endocrine related cancers acting via modulation of Akt-pathway
Keywords: HEK، کلیه جنین انسان; Alkylphospholipid; Dithiocarbamate; Akt-pathway; Endocrine cancer; Miltefosine; Anti-proliferative agentAPCs, alkylphosphocholines; DDTC, diethyldithiocarbamate; HEK, human embryonic kidney; PI, propidium iodide; MMP, mitochondrial membrane potential; ATC
The proximal promoter of a novel interleukin-8-encoding gene in rainbow trout (Oncorhynchus mykiss) is strongly induced by CEBPA, but not NF-κB p65
Keywords: HEK، کلیه جنین انسان; Aa, amino acids; CEBP, CCAAT/enhancer-binding proteins; GFP, green-fluorescent protein; HEK, human embryonic kidney; hpi, hours post infection; LUC, luciferase; NF-κB, nuclear factor of kappa light chain gene enhancer in B cells; RT-qPCR, real-time quanti
Goat activin receptor type IIB knockdown by muscle specific promoter driven artificial microRNAs
Keywords: HEK، کلیه جنین انسان; ACVR2B, activin receptor type IIB; amiRNA, artificial microRNA; CMV, cytomegalovirus; DAB, 3,3′-diaminobenzidine; DAPI, 4′,6-diamidino-2-phenylindole; HEK, human embryonic kidney; MCK, muscle creatine kinase; MEF2C, myocyte enhancer factor 2C; MLC-1, myos
The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor
Keywords: HEK، کلیه جنین انسان; CI-MPR, cation-independent mannose 6-phosphate receptor; EGFR, epidermal growth factor receptor; GGA, Golgi-localized ϒ ear containing, ARF binding protein; HEK, human embryonic kidney; PACS, phosphofurin acidic cluster protein-1; siRNA, small interfering
Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins
Keywords: HEK، کلیه جنین انسان; IgG, immunoglobulin G; IVIG, intravenous immunoglobulin G; PDB, Protein Data Bank; HEK, human embryonic kidney; CHO, Chinese hamster ovary; LC, liquid chromatography; ESI, electrospray ionization; MS, mass spectrometry; MM, molecular mass; PEG, polyethyle
The role of human growth hormone's C-terminal disulfide bridge
Keywords: HEK، کلیه جنین انسان; (h)GH, (human) growth hormone; wt, wild type; HEK, human embryonic kidney; GHR, GH receptor; GHBP, GH binding protein; GHRH, GH releasing hormone; SST, somatostatin; IGF, insulin-like growth factor; Jak, Janus kinase; STAT, signal transducer and activator
A bioassay for Lafora disease and laforin glucan phosphatase activity
Keywords: HEK، کلیه جنین انسان; BSA, bovine serum albumin; CBM, carbohydrate binding module; CSF, cerebrospinal fluid; DSP, dual specificity phosphatase; DTT, dithiothreitol; HRP, horseradish peroxidase; HEK, human embryonic kidney; LB, Lafora body; LD, Lafora disease; mRIPA, modified R
Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay
Keywords: HEK، کلیه جنین انسان; Protein kinase Myt1; Binding assay; Inhibitor; Organic synthesis; DockingBCA, bicinchoninic acid; Cdk1, cyclin dependent kinase 1; CycB, cyclin B; DMSO, dimethylsulfoxide; DTT, dithiothreitol; GGL, glycoglycerolipid; HEK, human embryonic kidney; HR-MS, hi
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells
Keywords: HEK، کلیه جنین انسان; DAT, dopamine transporter; DA, dopamine; Mn, manganese; HEK, human embryonic kidney; NEDD-4, neural precursor cell expressed developmentally down-regulated protein 4; AMPH, amphetamineManganese; Manganism; Dopamine transporter; DAT; HEK cells; Dopamine
ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1
Keywords: HEK، کلیه جنین انسان; ABC, ATP-binding cassette; BSA, bovine serum albumin; DDM, n-dodecyl-β-d-maltopyranoside; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; HBSS, Hank's balanced salt solution; HEK, human embryonic kidney; HRP, h
The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels
Keywords: HEK، کلیه جنین انسان; SK/KCa2 channel, small conductance calcium-activated potassium channel; mAHP, medium afterhyperpolarization; CaM, calmodulin; CNS, central nervous system; TEA, tetraethylammonium; HEK, human embryonic kidney; EDTA, ethylene diamine tetraacetic acid; PEI,
Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG
Keywords: HEK، کلیه جنین انسان; CHO, Chinese hamster ovary; cLogP, calculated logP, where P is the partition coefficient between n-octanol and water; Cm, membrane capacitance; HEK, human embryonic kidney; hERG, human ether-à-go-go related gene; IC50, 50% inhibitory concentration; IW, Io
Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4
Keywords: HEK، کلیه جنین انسان; ATP, adenosine triphosphate; BSA, bovine serum albumin; HBSS, Hank's Balanced Salt Solution; HEK, human embryonic kidney; HEPES, hydroxyethylpiperazine ethanesulfonic acid; IC50, concentration at which 50% inhibition is obtained; MRP, multidrug resistance
Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model
Keywords: HEK، کلیه جنین انسان; ERK1/2, extracellular-signal-regulated kinases 1 and 2; HEK, human embryonic kidney; HFD, high fat diet; HIF-1α, hypoxia-inducible factor 1 alpha; p38 MAPK, p38 mitogen activated phosphate kinase; MDA, malondialdehyde; NEAT, non-exercise activity thermoge
CB2: Therapeutic target-in-waiting
Keywords: HEK، کلیه جنین انسان; CHO, Chinese hamster ovary; CNS, central nervous system; ERK, extracellular-regulated kinase; GPCR, G protein-coupled receptor; GRK, G protein receptor kinase; HEK, human embryonic kidney; JNK, c-jun N terminal kinase; MAP kinase, mitogen-activated protei
ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation
Keywords: HEK، کلیه جنین انسان; ARD1, arrest-defective 1 protein; RIP1, receptor-interacting protein 1; HA, hemagglutinin; Myc, c-Myc; TNF, tumor necrosis factor; HEK, human embryonic kidney; MEF, mouse embryonic fibroblast; NLS, nuclear localization signalARD1; RIP1; NF-κB; Doxorubicin
A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens
Keywords: HEK، کلیه جنین انسان; Ad, adenovirus vector; Ag, antigen; APC, antigen-presenting cell; DC, dendritic cell; dDC, dermal dendritic cell; ELISA, enzyme-linked immunosorbent assay; ELISPT, enzyme-linked immunospot; FITC, fluorescein isothiocyanate; HEK, human embryonic kidney; ID
A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance
Keywords: HEK، کلیه جنین انسان; AJ23, 7-methyl-1-phenyl-1,8-dihydropyrazolo-(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one; ACSF, artificial cerebrospinal fluid; CHO, Chinese Hamster Ovary; DMSO, d6 – dimethylsulphoxide; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; HEK, Human Embryonic Kidney
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels
Keywords: HEK، کلیه جنین انسان; Nav, voltage-gated sodium channel; Acm, acetamidomethyl; Boc, tertbutyloxycarbonyl; CHO, Chinese hamster ovarian; DCM, dichloromethane; DIEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; DRG, dorsal root ganglion; HEK, human embryonic kidney; HE
Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes
Keywords: HEK، کلیه جنین انسان; AMPK, AMP-activated protein kinase; cAMP, cyclic adenosine 3′,5′-monophosphate; ERK, extracellular signal-regulated kinase; 4E-BP1, eIF4E-binding protein 1; Gs, stimulatory GTP-binding protein; GTP, guanosine triphosphate; HEK, human embryonic kidney; IGF
Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9
Keywords: HEK، کلیه جنین انسان; TLR, toll-like receptor; CpG-ODN, CpG-oligodeoxynucleotides; NF-κB, nuclear factor-κB; MyD88, myeloid differentiation factor 88; IRAK, IL-1R associated-kinase; TRAF6, TNFR-activated factor 6; TAK1, TGF-β-activating kinase; HEK, human embryonic kidney; FCS
Human blood-derived fibrin releasates: Composition and use for the culture of cell lines and human primary cells
Keywords: HEK، کلیه جنین انسان; Growth factors; Platelet; Blood; Cell culture; FBSbFGF, basic fibroblast growth factor; EGF, epidermal growth factor; IGF, insulin-like growth factor; Ig, immunoglobulin; FBS, fetal bovine serum; GIF, gingival fibroblast; HEK, human embryonic kidney; PDGF
The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function
Keywords: HEK، کلیه جنین انسان; 7-CK, 7-chlorokynurenic acid; AP5, d,l-2-amino-5-phosphonopentanoic acid; CIAP, calf intestinal alkaline phosphatase; GFP, green fluorescent protein; HEK, human embryonic kidney; HEPES, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid; IK, somatic