کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070860 1544592 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments
ترجمه فارسی عنوان
بهره برداری از فن آوری سلول های بنیادی چندگانه برای کشف، غربالگری، ایمنی و ارزیابی مواد سمی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

In order for the pharmaceutical industry to maintain a constant flow of novel drugs and therapeutics into the clinic, compounds must be thoroughly validated for safety and efficacy in multiple biological and biochemical systems. Pluripotent stem cells, because of their ability to develop into any cell type in the body and recapitulate human disease, may be an important cellular system to add to the drug development repertoire. This review will discuss some of the benefits of using pluripotent stem cells for drug discovery and safety studies as well as some of the recent applications of stem cells in drug screening studies. We will also address some of the hurdles that need to be overcome in order to make stem cell-based approaches an efficient and effective tool in the quest to produce clinically successful drug compounds.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volumes 69–70, 20 April 2014, Pages 170–178
نویسندگان
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