دانلود مقالات ISI درباره کانال HERG + ترجمه فارسی

Suppression of hERG K+ current and cardiac action potential prolongation by 4-hydroxynonenal via dual mechanisms

Keywords: کانال HERG; IKr; rapidly activating delayed rectifier potassium current in cardiomyocyte; IKs; slowly activating delayed rectifier potassium current in cardiomyocyte; ICa,L; , L-type calcium current in cardiomyocyte; IhERG; outward K+ current in hERG overexpressed co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs

Keywords: کانال HERG; hERG channel; Strychnine; Brucine; N-oxide; Alanine-mutagenesis; Docking simulations;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Cardiologist's point of view: Novel ECG biomarkers and in silico models for proarrhythmic risk prediction: Are we ready?

Keywords: کانال HERG; QT prolongation; hERG channel; Proarrhythmia; Torsades de pointes;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Proarrhythmic risk assessment using conventional and new in vitro assays

Keywords: کانال HERG; Action potential; Arrhythmia; Cardiac safety pharmacology; Field potential; hERG channel; Human-induced pluripotent stem cell-derived cardiomyocytes; Multielectrode arrays; Purkinje fiber;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Mechanism of inhibition by olanzapine of cloned hERG potassium channels

Keywords: کانال HERG; hERG channel; Olanzapine; Open-channel block;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels

Keywords: کانال HERG; hERG channel; Tamoxifen; Endoxifen; Channel trafficking

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

Keywords: کانال HERG; PI(4)P5-K; HERG channel; PI(4,5)P2; Gq protein-coupled receptors; Arrhythmiaα1R, α1-adrenergic receptors; CHO, Chinese hamster ovary; IKr, delayed rectifier K+ current; DAG, diacylglycerol; GqRs, Gq protein-coupled receptors; HERG, human ether-a-go-go-rel

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia

Keywords: کانال HERG; Acquired long QT syndrome; hERG channel; hERG trafficking inhibition; Safety pharmacology;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide

Keywords: کانال HERG; Domiphen bromide (PubChem CID: 10866); Didecyl dimethylammonium bromide (PubChem CID: 16957)Quaternary ammonium compounds; Patch clamp; HERG channel

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies

Keywords: کانال HERG; ASO; Antisense Oligonucleotide; CNS; Central Nervous System; ECG; Electrocardiography; FOB; Functional Observatory Battery; GLP; Good Laboratory Practice; hERG; Human Ether-a-go-go related gene; ICH; International Conference on Harmonisation; IC50; The ha

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Cardiovascular pharmacologyBlock of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration

Keywords: کانال HERG; Action potential duration; Antipsychotic drug; hERG channel; Fluphenazine; Rapidly-activating delayed rectifier K+ channel;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacophore modeling for hERG channel facilitation

Keywords: کانال HERG; hERG; human ether-a-go-go-related gene; 3D-QSAR; three-dimensional-quantitative structure activity relationships; V1/2; the half maximal of voltage dependence of activation; IC50; the half maximal concentration for inhibition; EC50; the half maximal conce

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Deciphering hERG channels: Molecular basis of the rapid component of the delayed rectifier potassium current

Keywords: کانال HERG; AP; action potential; CNB domain; cyclic nucleotide binding domain; ER; endoplasmatic reticulum; ERG; ether-a-go-go-related gene; HEK cells; human embryonic kidney cells; IKr; delayed rectifier potassium current; PAS domain; Per-Arnt-Sim domain; hERG chan

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship

Keywords: کانال HERG; Serotonin receptor 5-HT6; Antagonists; Phenylsulfonyl-pyrazolo-pyrido-pyrimidines; Specificity; hERG channel;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Microwave assisted synthesis of spirocyclic pyrrolidines – σ1 receptor ligands with modified benzene-N-distance

Keywords: کانال HERG; σ Receptor ligands; Spirocyclic pyrrolidines; Microwave irradiation; Receptor binding studies; Structure affinity relationships; hERG channel

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Acute alteration of cardiac ECG, action potential, IKr and the human ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77

Keywords: کانال HERG; Action potential; ECG; hERG channel; PCB 126; PCB 77; Short QT syndrome;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

hERG channel blockade by externally applied quaternary ammonium derivatives

Keywords: کانال HERG; hERG channel; Quaternary ammonium; Hydrophobicity; Cation-π interaction; Inactivation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Fluconazole inhibits hERG K+ channel by direct block and disruption of protein trafficking

Keywords: کانال HERG; Fluconazole; hERG channel; Long QT syndrome; hERG protein trafficking; Human embryonic kidney cell

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

Keywords: کانال HERG; Bupivacaine; Cardiotoxicity; Electrophysiology; hERG channel; Molecular docking; Stereoselectivity; AP; action potential; cLQTS; congenital long QT syndrome; diLQTS; drug-induced long QT syndrome; ECG; electrocardiogram; ES; extracellular solution; GB/SA;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists

Keywords: کانال HERG; Phenylsulfonyl-pyrazolo[1,5-a]pyrimidines; 5-HT6 receptor; 5-HT6 antagonist; 5-HT2B receptor; 5-HT2B antagonist; hERG channel

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

A family of hereditary long QT syndrome caused by Q738X HERG mutation

Keywords: کانال HERG; Genetic mutation; HERG channel; Long QT syndrome; Torsade de Pointes;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine

Keywords: کانال HERG; Arrhythmias; Desipramine; hERG channel; LQT; Rapidly-activating delayed rectifier K+ current; Torsades de pointes; Tricyclic antidepressant

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs

Keywords: کانال HERG; Astemizole; hERG channel; IKr; Teratogenicity; Hypoxia; Embryonic cardiac adverse effects

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity

Keywords: کانال HERG; ORL1 antagonist; Nociceptin/orphanin FQ; Benzimidazole; hERG channel

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Discovery of novel arylpyrazole series as potent and selective opioid receptor-like 1 (ORL1) antagonists

Keywords: کانال HERG; ORL1 antagonist; Nociceptin/orphanin FQ; Arylpyrazole; hERG channel

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Comparative effects of sophocarpine and sophoridine on hERG K+ channel

Keywords: کانال HERG; HEK293 cell; hERG channel; Patch clamp; Sophocarpine; Sophoridine; Western blot

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

H1 antihistamine drug promethazine directly blocks hERG K+ channel

Keywords: کانال HERG; Antihistamine; Action potential duration; hERG channel; Promethazine; Rapidly activating delayed rectifier K+ channel

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine

Keywords: کانال HERG; ORL1; Antagonist; N-Biarylmethyl spiropiperidine; hERG channel

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Doxazosin induces apoptosis of cells expressing hERG K+ channels

Keywords: کانال HERG; Antihypertensive drug; Apoptosis; Congestive heart failure; Doxazosin; hERG channel; Potassium channel

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Clomipramine block of the hERG K+ channel: Accessibility to F656 and Y652

Keywords: کانال HERG; Arrhythmia; Clomipramine; hERG channel; LQT; Rapidly activating delayed rectifier K+ current; Torsades de pointes; Tricyclic antidepressant;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel

Keywords: کانال HERG; Protriptyline; Tricyclic antidepressant; HERG channel; Long QT syndrome; Arrhythmias

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

A novel hypothesis for the binding mode of HERG channel blockers

Keywords: کانال HERG; HERG channel; LQT syndrome; Virtual docking; In silico prediction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Template switching within exons 3 and 4 of KV11.1 (HERG) gives rise to a 5′ truncated cDNA

Keywords: کانال HERG; HERG channel; RT slippage; Template switching; Brain; Cardiac; Gastrointestinal

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine

Keywords: کانال HERG; Prochlorperazine; Antiemetic drug; HERG channel; IKr; Long QT syndrome; Arrhythmias

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Effects of fluoroquinolones on HERG channels and on pancreatic β-cell ATP-sensitive K+ channels

Keywords: کانال HERG; Fluoroquinolones; HERG channel; KATP channel; Pore-forming Kir6.2 subunit;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform

Keywords: کانال HERG; Chloroform; HERG channel; Arrhythmia; Trichlormethane; Potassium channels; Intoxication;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve

Keywords: کانال HERG; Action potential; Beagle dog; Cardiac repolarization; Droperidol; hERG channel; ICH S7B; Purkinje fiber; QT interval; Reprolarization reserve; Sotalol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

Keywords: کانال HERG; Action potential; Channel/receptor crosstalk; Gene expression; hERG channel; In silico models; In vitro models; In vivo models; QT interval; Torsades de Pointes

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2006 سفارش ترجمه

A two-state homology model of the hERG K+ channel: application to ligand binding

Keywords: کانال HERG; hERG channel; Homology model; Ligand binding; Structure based design;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه