Keywords: HFD، رژیم غذایی با چربی بالا; DIO, diet-induced obesity; HFD, high-fat diet; CR, calorie restriction; LXR, liver X receptors; FXR, farnesoid X receptor; STZ, streptozotocin; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; PUFAs, polyunsaturated fatty acids; MetS, metabolic synd
مقالات ISI HFD، رژیم غذایی با چربی بالا (ترجمه نشده)
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Keywords: HFD، رژیم غذایی با چربی بالا; Atg, Autophagy-related gene; PD, Parkinson׳s disease; Aβ, Amyloid-β peptide; AD, Alzheimer׳s disease; HD, Huntington׳s disease; HFD, High-fat diet; ER, Endoplasmic reticulum; LC3, Microtubule-associated protein light chain 3; CNS, Central nervous system;
Keywords: HFD، رژیم غذایی با چربی بالا; Obesity; Diet modulation; Fat loss; Iron status; MouseBMP, bone morphogenetic protein; Dcytb, duodenal cytochrome b; p-Smad, phosphorylated Smad; HFD, high-fat diet; mRNA, messenger RNA
Keywords: HFD، رژیم غذایی با چربی بالا; HFD, high-fat diet; RD, regular dietdiet induced obesity; sex; photophobia; trigeminal; migraine; capsaicin
Keywords: HFD، رژیم غذایی با چربی بالا; Rat; Diet; Exercise; Obesity; Estrogen receptorAUC, area under the curve; E2, 17β-estradiol; ERα, estrogen receptor α; ERβ, estrogen receptor β; HFD, high-fat diet; HF-HS, high-fat, high-sucrose diet; HOMA index, homeostatic model assessment index; IRS1,
Keywords: HFD، رژیم غذایی با چربی بالا; BMC, bone mineral content; BS, bone surface; BV, bone volume; CF, control-fed; Conn.Dn., connectivity density; CTX-1, C-terminal telopeptide of type 1 collagen; FGF21, fibroblast growth factor-21; HFD, high-fat diet; HHCy, hyperhomocysteinemia; IDI, inden
Keywords: HFD، رژیم غذایی با چربی بالا; Control + Met, control and methyl donor supplement; HFD, high-fat diet; HFD + Met, high-fat diet and methyl donor supplement; WAT, white adipose tissue; BAT, brown adipose tissue; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cho
Keywords: HFD، رژیم غذایی با چربی بالا; BSA, bovine serum albumin; DAG, diacylglycerol; FA, fatty acids; FFA, free fatty acids; GTT, glucose tolerance tests; HFD, high-fat diet; IDDM, insulin-dependent diabetes mellitus; IPGTT, intraperitoneal glucose tolerance tests; ITT, insulin tolerance tes
Keywords: HFD، رژیم غذایی با چربی بالا; MLE, mulberry leaf extract; MLPE, mulberry leaf polyphenolic extract; HFD, high-fat diet; HPLC, high-performance liquid chromatography; NAFLD, non-alcoholic fatty liver disease; FAS, fatty acid synthase; SREBPs, sterol regulatory element binding proteins;
Keywords: HFD، رژیم غذایی با چربی بالا; Astrocyte; Glia; High-fat diet; Nuclear factor-kappaB; Food intake; HypothalamusCNS, central nervous system; GFAP, glial-fibrillary acidic protein; HFD, high-fat diet; MBH, medial basal hypothalamus; NFκB, nuclear factor kappa B
Keywords: HFD، رژیم غذایی با چربی بالا; WAT, white adipose tissue; BAT, brown adipose tissue; HFD, high-fat diet; ND, normal diet; PPI, protein–protein interaction; GSEA, gene set enrichment analysis; DEG, differentially expressed gene; FDR, false discovery rateWhite adipose tissue; Brown adipo
Keywords: HFD، رژیم غذایی با چربی بالا; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; HFC, high fat, high cholesterol and cholate; RSV, resveratrol; AMPK, AMP-activated protein kinase; SIRT1, silent information regulation-2 homolog-1; HFD, high-fat diet; TG, tri
Keywords: HFD، رژیم غذایی با چربی بالا; PCE, prenatal caffeine exposure; HPA, hypothalamic–pituitary–adrenocortical; MS, metabolic syndrome; IUGR, intrauterine growth retardation; HFD, high-fat diet; ACTH, adrenocorticotropic hormone; CORT, corticosterone; TG, triglyceride; TCH, cholesterol; GC
Keywords: HFD، رژیم غذایی با چربی بالا; Dysbiosis; Leaky Gut; Alcoholic Liver Disease; NASH; NAFLD; Cirrhosis; Microbiome; PAMPsALD, alcoholic liver disease; AMP, antimicrobial peptides and proteins; Fiaf, fasting-induced adipocyte factor; HFD, high-fat diet; IBD, inflammatory bowel disease; IL
Keywords: HFD، رژیم غذایی با چربی بالا; Adipokine; Endotoxin; Mice; Intestine; MicrobiotaANOVA, analysis of variance; ELISA, enzyme-linked immunosorbent assay; HFD, high-fat diet; IL-6, interleukin-6; LBP, lipopolysaccharide-binding protein; LFD, low-fat diet; LPS, lipopolysaccharide; mHFD, mod
Keywords: HFD، رژیم غذایی با چربی بالا; D1, type 1 deiodinase; D2, type 2 deiodinase; DIO, diet-induced obesity; EE, energy expenditure; FBG, fasting blood glucose; FFA, free fatty acids; Gpx, glutathione peroxidase; HFD, high-fat diet; HPT axis, hypothalamus–pituitary–thyroid axis; LFD, low-fa
Keywords: HFD، رژیم غذایی با چربی بالا; DKO, Lcn2−/−;SCD1 SKO; HFD, high-fat diet; SCD1, stearoyl-CoA desaturase 1; GKO, SCD1 global knockout; MUFA, monounsaturated fatty acids; RAR, retinoic acid receptor; SKO, SCD1 skin knockout; TG, triglycerides; WAT, white adipose tissueStearoyl-CoA desatu
Keywords: HFD، رژیم غذایی با چربی بالا; Inflammation; Lipids; Monocytes; Obesity; Humans; Fatty acidsBSA, bovine serum albumin; ELISA, enzyme-linked immunosorbent assay; FFA, free fatty acid; HFD, high-fat diet; IL, interleukin; NADPH, nicotinamide adenine dinucleotide phosphate; p47phox, p47 s
Keywords: HFD، رژیم غذایی با چربی بالا; ACO, acyl-coenzyme A oxidase; ANOVA, analysis of variance; CGH, corn gluten hydrolysate; CPT-1α, carnitine palmitoyltransferase 1α; DIO, diet-induced obesity; GLUT4, glucose transporter 4; HFD, high-fat diet; HOMA-IR, homeostasis model assessment–insulin
Keywords: HFD، رژیم غذایی با چربی بالا; HFD, high-fat diet; OVX, ovariectomy; sham, sham-operated; HFOE, ovariectomized HFD-fed rats with estradiol administration; HFOV, ovariectomized HFD-fed rats with vehicle treatment; HFSV, sham HFD-fed rats with vehicle treatment; ND, normal diet; NDOE, ov
Keywords: HFD، رژیم غذایی با چربی بالا; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CT, computed tomography; CVD, cardiovascular disease; FBG, fibrinogen fasting levels of glucose; HDL, high-density lipoprotein; HFD, high-fat diet; HOMA, homeostasis mod
Keywords: HFD، رژیم غذایی با چربی بالا; ANOVA, analysis of variance; CD11b, cluster of differentiation molecule 11B; CHD, control house chow diet; GR, glucocorticoid receptor; HFD, high-fat diet; HPA, hypothalamic–pituitary–adrenal; IkBa, I-kappa-B-alpha; IL-1Ra, interleukin-1 receptor antagoni
Keywords: HFD، رژیم غذایی با چربی بالا; ALT, alanine aminotransferase; ER, endoplasmic reticulum; FFA, free fatty acid; HFD, high-fat diet; HSP70, heat shock protein 70; mtHSP70, mitochondrial heat shock protein 70; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; PA
Keywords: HFD، رژیم غذایی با چربی بالا; 4-HNE, 4-hydroxy-2-nonenal; ATF6, activating transcription factor 6; BiP, binding immunoglobulin protein; EIF2α, eukaryotic initiation factor 2 alpha; FAs, fatty acids; Fis1, fission 1; H&E, hematoxylin and eosin; HFD, high-fat diet; IRE1, inositol-requir
Keywords: HFD، رژیم غذایی با چربی بالا; HFD, high-fat diet; PXR, pregnane X receptor; mPXR, mouse PXR; hPXR, PXR-humanized or human PXR; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue; ALT, alanine transaminase; PPARs, peroxisome proliferator-activated receptors; LBD, ligan
Keywords: HFD، رژیم غذایی با چربی بالا; STD, standard diet; HFD, high-fat diet; BMI, body mass index; TC, thoracic circumference; AC, abdominal circumference; AI, adiposity index; AT, adipose tissue; TNFα, tumor-necrosis factor-α; IL-6, interleukine-6; ELISA, enzyme-linked immunosorbent assay;
Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation
Keywords: HFD، رژیم غذایی با چربی بالا; ApoE−/−, apolipoprotein E-deficient; TLRs, Toll-like receptors; NF-κB, NF-kappa B; PI3K-Akt, phosphatidylinositol 3′-kinase-Akt-dependent; HFD, high-fat diet; PCCP, perivascular carotid collar placement; ELISA, enzyme-linked immunosorbent assay; ox-LDL, o
Alternate-day fasting protects the livers of mice against high-fat diet–induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling
Keywords: HFD، رژیم غذایی با چربی بالا; Alternate-day fasting; Calorie restriction; Liver; Inflammation; MouseADF, alternate-day fasting; ANOVA, analysis of variance; CHD, chow diet; CRP, C-reactive protein; ER, energy restriction; H&E, hematoxylin and eosin; HFD, high-fat diet; IL, interleukin
Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats
Keywords: HFD، رژیم غذایی با چربی بالا; Antiobesity effect; Gingerol; Ginger; High-fat diet; InsulinHDL, High - Density Lipoprotein; HFD, High-Fat Diet; FAS, Fatty Acid Synthase; ACC, Acetyl Co-A Carboxylase; CPT-1, Carnitine Palmitoyl Transferase-1; HMGR, HMG coA reductase; LCAT, Lecithin Chol
Tongqiaohuoxue decoction ameliorates obesity-induced inflammation and the prothrombotic state by regulating adiponectin and plasminogen activator inhibitor-1
Keywords: HFD، رژیم غذایی با چربی بالا; THD, Tongqiaohuoxue decoction; HFD, high-fat diet; HFD+THD, THD-treated mice on a HFD; PAI-1, plasminogen activator inhibitor-1; TNF, tumor necrosis factor; MCP-1, monocyte chemoattractant protein-1; IL, interleukin; TG, triglyceride; tPA, tissue-type pla
High dietary fat–induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism
Keywords: HFD، رژیم غذایی با چربی بالا; Diabetes; High-fat diet; Vitamin A; GK rat; RBP4GK, Goto-Kakizaki; HFD, high-fat diet; HPLC, high-performance liquid chromatography; qPCR, quantitative polymerase chain reaction; Raldh, retinaldehyde dehydrogenase (Aldh1a1); RARβ, retinoic acid receptor β
Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice
Keywords: HFD، رژیم غذایی با چربی بالا; Corosolic acid; AMPK; Inflammation; Insulin resistance; Adipose tissueCRA, corosolic acid; HFD, high-fat diet; IR, insulin resistance; TG, triglyceride; TC, total cholesterol; FBG, fasting blood glucose; Fins, fasting insulin; Mac-CM, macrophages-derived
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding
Keywords: HFD، رژیم غذایی با چربی بالا; ABCA1, ATP-binding cassette, subfamily A (ABC1), member 1; CD38, cyclic ADP-ribose hydrolase 1; HDL, High-density lipoprotein; HFD, High-fat diet; HIC1, Hypermethylated in cancer 1; LDL, Low-density lipoprotein; LFD, Low-fat diet; KanR, Kanamycin resistan
Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling
Keywords: HFD، رژیم غذایی با چربی بالا; DIO, high fat diet-induced obese; AMPK, 5′ AMP-activated protein kinase; SREBP2, sterol regulatory element-binding transcription factor 2; FNDC5, fibronectin type β domain containing 5; OA, oleic acid; NCD, normal chow diet; HFD, high-fat diet; BW, body w
Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice
Keywords: HFD، رژیم غذایی با چربی بالا; Myenteric Neurons; Palmitate; Gut Microbiota; LPS; TLR4; Colon TransitFITC, fluorescein isothiocyanate; HEK, human embryonic kidney; HFD, high-fat diet; IM-PEN, immortal postnatal enteric neuronal; JNK, c-Jun N-terminal kinase; LCM, laser capture microdis
Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells
Keywords: HFD، رژیم غذایی با چربی بالا; Mouse Model; Hormones; Immune Regulation; IncretinAB, antibody; cAMP, cyclic adenosine monophosphate; FACS, fluorescence-activated cell sorting; GIP, glucose-dependent insulinotropic polypeptide; GLP, glucagon-like peptide; HFD, high-fat diet; IL, interle
Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue
Keywords: HFD، رژیم غذایی با چربی بالا; Adipose tissue; Citrulline; Adiponectin; Leptin; Aging; ObesityASL, argininosuccinate lyase; ASS, argininosuccinate synthase; CD, control diet; CIT, citrulline; HFD, high-fat diet; IL, interleukin; INFγ, interferon gamma; NOS, nitric oxide synthase; NFκB,
p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice
Keywords: HFD، رژیم غذایی با چربی بالا; 1110001J03Rik; Glucose-induced insulin secretion; High-fat diet; Lipid peroxidative stress; PACAP; Type 2 diabetes4-HNE, 4-hydroxynonenal; HFD, high-fat diet; OGTT, oral glucose tolerance test; p13-Tg mice, transgenic mice overexpressing p13 in pancreatic
A high-fat diet is associated with altered adipokine production and a more aggressive esophageal adenocarcinoma phenotype in vivo
Keywords: HFD، رژیم غذایی با چربی بالا; CD, control diet; EAC, esophageal adenocarcinoma; HFD, high-fat diet; NOD, nonobese diabetic; SCID, severe combined immune-deficient; 2DG, 2-deoxyglucose7; 8.1; 29; 43.4
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice
Keywords: HFD، رژیم غذایی با چربی بالا; DIO, diet-induced obesity; eWAT, epididymal white adipose tissue; HFD, high-fat diet; PD, Parkinson’s diseaseDiet-induced obesity; Park7; DJ-1; Mice; Neurodegeneration; High-fat diet
Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity
Keywords: HFD، رژیم غذایی با چربی بالا; ALS, acid-labile subunit; AUC, area under the curve; GTT, glucose tolerance test; HFD, high-fat diet; IGF, insulin-like growth factor; IGFBP, insulin-like growth factor binding protein; PAPP-A2, pregnancy associated plasma protein-A2; piAUC, positive incr
TLR4 antagonist attenuates atherogenesis in LDL receptor-deficient mice with diet-induced type 2 diabetes
Keywords: HFD، رژیم غذایی با چربی بالا; TLR, toll-like receptor; LDLR−/− mice, low-density lipoprotein receptor-deficient mice; RC, regular chow; HFD, high-fat diet; LPS, lipopolysaccharide; Rs-LPS, Rhodobacter sphaeroides LPS; NFκB, nuclear factor kappa B; MAPK, mitogen-activated protein kinas
ACE2 deficiency shifts energy metabolism towards glucose utilization
Keywords: HFD، رژیم غذایی با چربی بالا; ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; Ang, angiotensin; AT receptor, angiotensin II receptor; GLUT-1, glucose transporter-1; GLUT-4, glucose transporter-4; HFD, high-fat diet; IGF-1, insulin growth factor-1; IPGTT, int
Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice
Keywords: HFD، رژیم غذایی با چربی بالا; NAFLD, non-alcoholic fatty liver disease; ChIP, chromatin immunoprecipitation; HFD, high-fat diet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FFA, free fatty acid; FAS, fatty acid synthase; SCD1, stearoyl coenzyme A desaturase 1; SREB
Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice
Keywords: HFD، رژیم غذایی با چربی بالا; ANT, adenine nucleotide translocase; EDL, extensor digitorum longus; FA, fatty acid; FT, fast twitch; FTI, force–time integral; HFD, high-fat diet; HFL, high-fat diet containing lard; HFP, high-fat diet containing palm oil; LCAD, long-chain acyl-CoA dehyd
Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice
Keywords: HFD، رژیم غذایی با چربی بالا; CYP7A1, cholesterol 7α-hydroxylase; CYP7A1-tg mice, transgenic mice overexpressing CYP7A1 in the liver; HFD, high-fat diet; UPLC-ESI-QTOFMS, ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectr
FTO is necessary for the induction of leptin resistance by high-fat feeding
Keywords: HFD، رژیم غذایی با چربی بالا; Fto; Leptin resistance; High-fat diet; NFкB; TRIP4; Hypothalamus; SOCS3GWAS, Genome-wide association studies; SNPs, single nucleotide polymorphisms; FTO, FaT mass and Obesity related; HFD, high-fat diet; MEF, Mouse embryonic fibroblasts; Y2H, Yeast two-hy
Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice
Keywords: HFD، رژیم غذایی با چربی بالا; Density-enhanced phosphatase-1; Glucose homeostasis; Insulin signaling; Insulin resistance; PhosphorylationDEP-1, density-enhanced phosphatase-1; GTT, glucose tolerance test; HFD, high-fat diet; IL-6, interleukin 6; IR, insulin receptor; ITT, insulin tole
Extracts and lignans of Schisandra chinensis fruit alter lipid and glucose metabolism in vivo and in vitro
Keywords: HFD، رژیم غذایی با چربی بالا; SF, S. chinensis fruit; HFD, high-fat diet; XZK, xuezhikang tablet; SDC, schisandrin C; HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; TC, total cholesterol; TG, triacylglycerol; OGTT, oral glucose tolerance test;
TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress
Keywords: HFD، رژیم غذایی با چربی بالا; Adv, adenovirus; CHX, cycloheximide; Dgat1, DAG acyltransferase; ER, endoplasmic reticulum; FAS, fatty acid synthase; FBS, fetal bovine serum; GST, glutathione-s-transferase; HA, hemagglutinin; HFD, high-fat diet; KO, knockout; MCD, methionine and choline