Keywords: هیستون دی متیلاز; Histone methylation; Histone demethylation; Lung cancer; Histone methyltransferase; Histone demethylase; Inhibitors; ALK; anaplastic lymphoma kinase; DUSP3; dual-specificity phosphatase 3; Elk1; ETS-domain containing protein; EMT; epithelial-to-mesenchyma
مقالات ISI هیستون دی متیلاز (ترجمه نشده)
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Keywords: هیستون دی متیلاز; AGE; advanced glycation end product; TLR; toll like receptor; FFA; free fatty acid; ROS; reactive oxygen species; c-JNK; c-Jun N-terminal kinase; HMT; histone methyltransferase; HDM; histone demethylase; DNMT; DNA methyltransferases; TET; ten-eleven trans
Keywords: هیستون دی متیلاز; Epigenetics; Histone demethylase; Inhibitor peptide; Cyclic peptide; Traceless linker; Redox-responsive linker;
Keywords: هیستون دی متیلاز; DNMT; DNA methyltransferase; HMT; histone methytransferase; HDMT; histone demethylase; HAT; histone acetylatransferase; HDAC; histone deacetylase; MBP; methy-CpG binding protein; DMAP1; DNMT1-associated protein; MBD; methy-CpG binding domain; FDA; Food an
Keywords: هیستون دی متیلاز; 4-HPR; N-(4-hydroxyphenyl)retinamide; 5â²-UTR; 5â²-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3â²,4â²-dihydro-1â²(2'H)-naphthalen-1â²-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met
Keywords: هیستون دی متیلاز; 5-AC; 5-Azacytidine; CTCL; cutaneous T-cell lymphoma; DNMT; DNA methyltransferase; EGCG; (â)-Epi-gallocatechin-3-gallate; HAT; histone acetylase; HDAC; histone deacetylase; HDM; histone demethylase; HKMT; SAM-dependent histone lysine methyltransferase;
Keywords: هیستون دی متیلاز; TH; Thyroid hormone; TR; Thyroid hormone receptor; T3; 3,5,3â² triiodothyronine; TRE; TH response element; DR; direct repeat; IR; inverted repeat or palindrome; ER; everted repeat; RXR; retinoic acid X receptor; dp; dominant positive; dn; dominant negati
The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression
Keywords: هیستون دی متیلاز; Histone demethylase; Jmjd3; Myelopoiesis; Spi1; Zebrafish;
The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons
Keywords: هیستون دی متیلاز; CGNs; cerebellar granule neurons; GNPs; granule neuron precursors; EGL; external granule layer; IGL; internal granule layer; H3K4me1 or H3K4me3; histone H3 lysine 4 monomethylation or trimethylation; H3K27me3; histone H3 lysine 27 trimethylation; JmjC; ju
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells
Keywords: هیستون دی متیلاز; LSD1/KDM1 inhibitor; CBB3001; Histone demethylase; Methylated H3K4 of histone H3; Teratocarcinoma; Embryonic carcinoma; SOX2; OCT4;
Vitamin C - A new player in regulation of the cancer epigenome
Keywords: هیستون دی متیلاز; 5caC; 5-carboxylcytosine; 5fC; 5-formylcytosine; 5hmC; 5-hydroxymethylcytosine; 5mC; 5-methylcytosine; AML; acute myeloid leukemia; DHA; dehydroascorbic acid; DNMT; DNA methyltransferase; DNMTis; DNA methyltransferase inhibitors; GLUT; glucose transporter
Original research articleHistone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation
Keywords: هیستون دی متیلاز; H3K27me3; Histone demethylase; Kdm6b; Cardiogenesis; Ventricle; Trabeculation;
The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice
Keywords: هیستون دی متیلاز; JMJD2A; 5-hydroxytryptamine; BDNF; Neuropathic pain; Histone demethylase;
Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1
Keywords: هیستون دی متیلاز; Histone demethylase; p53; Protein-protein interaction; Post-translational modification; Substrate specificity; Electrostatic interactions; CTD; C-terminal domain; p53-CTD; C-terminal domain of p53; TAMRA; carboxytetramethylrhodamine; DAB; diaminobutyric a
Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors
Keywords: هیستون دی متیلاز; Epigenetics; Histone demethylase; JMJD3 inhibitors; GSK-J1; Chelating group
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies
Keywords: هیستون دی متیلاز; Histone demethylase; KDM5; Selective KDM5 inhibitors; Epigenetics; Drug resistance; Lead optimization
The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer
Keywords: هیستون دی متیلاز; LSD1; Histone demethylase; Epigenetic modification; Oral cancer
The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells
Keywords: هیستون دی متیلاز; Myogenic differentiation; MyoD; KDM4B; Histone demethylase;
The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a
Keywords: هیستون دی متیلاز; AAV-Cre; adeno-associated virus with Cre recombinase; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; BIX-01924; G9a inhibitor; CA1; cornu ammonis 1; DNA; deoxyribonucleic acid; Drd1; dopamine recep
The role of the histone demethylase KDM4A in cancer
Keywords: هیستون دی متیلاز; KDM4A; histone demethylase; cancer; Jmjd2A; therapeutic target;
Integrated genomic analyses identify KDM1A's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer
Keywords: هیستون دی متیلاز; Oral cancer; Histone demethylase; KDM1A; E2F1 signaling; Cell proliferation;
The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators
Keywords: هیستون دی متیلاز; Fbxl11; Kdm2a; Histone demethylase; p21; Embryogenesis;
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures
Keywords: هیستون دی متیلاز; Epigenetics; Histone demethylase; Lysine-specific demethylase 1; Oligoamine; Antitumor agent;
KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature
Keywords: هیستون دی متیلاز; X-linked intellectual disability; KDM5C; JARID1C; Histone demethylase; Chromatin remodeling; Epigenetics
SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES
Keywords: هیستون دی متیلاز; epigenetics; histone demethylase; lysine-specific demethylase; protein-targeted drug delivery; ligand-protein interaction; drug discovery
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages
Keywords: هیستون دی متیلاز; SAA; serum amyloid A; H3K27me3; trimethylation of histone H3 at lysine 27; HDACs; histone deacetylases; FPR2; formyl peptide receptor 2; G-CSF; granulocyte colony-stimulating factor; IL-23p19; interleukin-23 alpha subunit p19; IL-12p40; interleukin-12 p40
DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila
Keywords: هیستون دی متیلاز; DEG; differentially expressed gene; H3K9me; histone H3 lysine 9 methylation; HP1; heterochromatin protein 1; KD; Knockdown; KDM; histone demethylase; KMT; histone methyltransferase; HP1a; HP1b; HP1c; Gene regulation; Microarray analysis;
Depletion of histone demethylase KDM2A enhanced the adipogenic and chondrogenic differentiation potentials of stem cells from apical papilla
Keywords: هیستون دی متیلاز; KDM2A; Histone demethylase; Adipogenic; Chondrogenic; Stem cells from apical papilla (SCAPs);
Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor
Keywords: هیستون دی متیلاز; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; ALOX5; arachidonate 5-lipoxygenase; AR; androgen receptor; CAMP; cathelicidin anti-microbial peptide; CCNC; cyclin C; CDKN1A; cyclin-dependent kinase inhibitor 1A; CoA; co-activato
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition
Keywords: هیستون دی متیلاز; Human carcinogenesis; Histone demethylase; JMJD2A; G1/S transition
Histone demethylase JMJD5 is essential for embryonic development
Keywords: هیستون دی متیلاز; E, embryonal day; ES, embryonic stem; β-geo, β-galactosidase/neomycin; JMJD, jumonji C domain-containingEmbryonic development; Gene knockout; Histone demethylase; JMJD5; p21; p53
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma
Keywords: هیستون دی متیلاز; Epigenomics; Epithelial-mesenchymal transition (EMT); Histone demethylase; Lysine methylation; Sarcoma epigenetics; Sarcoma genomics; Sarcoma therapy
A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay
Keywords: هیستون دی متیلاز; X-linked intellectual disability; JARID1C; KDM5C; Histone demethylase; Epigenetics; Chromatin remodeling;
Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions
Keywords: هیستون دی متیلاز; JmjC; Histone demethylase; RNA polymerase II; Transcription
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor
Keywords: هیستون دی متیلاز; Histone demethylase; Inhibitor; Epigenetic gene expression; Lysine-specific demethylase
Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
Keywords: هیستون دی متیلاز; JMJD2B; jumonji domain containing 2B; HDM; histone demethylase; JMJD2; jumonji domain-2; H3K9; histone H3 lysine 9; Epigenetics; Histone demethylase; JMJD2B; Gastric cancer; Tumorigenesis;
Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors
Keywords: هیستون دی متیلاز; Histone demethylase; Lysine-specific demethylase 1; Mesenchymal tumors; LSD1 inhibition
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
Keywords: هیستون دی متیلاز; Cancer; Corepressor; Histone demethylase; Krüppel-like transcription factor; Smad7; Transforming growth factor-βGST, glutathione S-transferase; JARID1B, jumonji AT-rich interactive domain 1B; JMJD, JmjC domain-containing; KDM5B, lysine-specific demethylas
The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase
Keywords: هیستون دی متیلاز; Tumor suppressor gene; Histone demethylase; JmjC domain; Transcription; Rb;
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
Keywords: هیستون دی متیلاز; Chromatin; Histone demethylase; Epigenetics; Drosophila; Gene control; Life span; Male-specific sex determination; Kdm4A
Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene
Keywords: هیستون دی متیلاز; Histone demethylase; JmjC-domain; Oncogene; Transcription; p53
Histone modifying enzymes: Structures, mechanisms, and specificities
Keywords: هیستون دی متیلاز; Chromatin; Transcription; Histone modification; Histone acetyltransferase; Histone demethylase
Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead
Keywords: هیستون دی متیلاز; Epigenetics; Chromatin remodelling; DNA methyltransferase; Histone deacetylase; Histone acetyltransferase; Histone methyltransferase; Histone demethylase
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
Keywords: هیستون دی متیلاز; Histone demethylase; Hypoxia; Jumonji domain containing 1A; JMJD1A; JHDM2A; HIF-1; Promoter
Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25Â Ã
Keywords: هیستون دی متیلاز; Chromatin; Histone demethylase; Nucleosome; SWIRM domain; Transcription;
Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes
Keywords: هیستون دی متیلاز; Histone methylation; Histone demethylase; Protein complex; BHC110/LSD1