Mechanisms of thyroid hormone receptor action during development: Lessons from amphibian studies

► Thyroid hormones induce metamorphosis that mimics the perinatal period in mammals. ► Amphibians provide an excellent model to analyze thyroid hormone receptor action. ► Thyroid hormone receptors act on gene expression through coregulators recruitment. ► Thyroid hormone receptor can change the chromatin structure and histone modifications. ► A model that highlights the diversity of thyroid hormone effects could be proposed.