Keywords: غالب منفی است; MMPs; Matrix metalloproteinases; ECM; extracellular matrix; TSP-2; Thrombospondin-2; FAK; focal adhesion kinase; Akt; protein kinase B; NF-κB; nuclear factor kappa B; Ig; immunoglobulin; DN; dominant negative; shRNA; short hairpin RNA; TCGA; The Cancer G
مقالات ISI غالب منفی است (ترجمه نشده)
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Keywords: غالب منفی است; Ectodermal dysplasia with immune deficiency; NF-κB inhibitor α; canonical nuclear factor κB pathway; noncanonical nuclear factor κB pathway; lymphorganogenesis; hematopoietic stem cell transplantation; AD EDA-ID; Autosomal dominant anhidrotic ectoderm
Keywords: غالب منفی است; AC; adenylate cyclase; Actn4; α-Actinin-4; ARF6; ADP-ribosylation factor 6; ATD; amino terminal domain; CAIN; calcineurin inhibitor protein; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; Cbln1; cerebellin 1 precursor; CC; coiled-c
Keywords: غالب منفی است; PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW-PTP; low molecular weight protein tyrosine phosphatase; LMW-AP; low molecular weight acid phosphatase; ACP1; gene coding for human LMW-PTP; PTP1B; tyrosine-protein phosphatase non-recept
Keywords: غالب منفی است; Ca2 +; calcium; CRC; colorectal cancer; CaSR; calcium-sensing receptor; PTH; parathyroid hormone; DMEM; Dulbecco's Modified Eagle's Medium; FBS; fetal bovine serum; Zeo; Zeocin; RPLPO; large ribosomal protein; β2M; beta-2-microglobulin; Eef1B2; eukaryot
Keywords: غالب منفی است; Resistance to thyroid hormone; Thyroid hormone receptor alpha; Dominant negative; Skeletal dysplasia;
Keywords: غالب منفی است; TH; Thyroid hormone; TR; Thyroid hormone receptor; T3; 3,5,3â² triiodothyronine; TRE; TH response element; DR; direct repeat; IR; inverted repeat or palindrome; ER; everted repeat; RXR; retinoic acid X receptor; dp; dominant positive; dn; dominant negati
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
Keywords: غالب منفی است; 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2- Deoxyglucose; 3-MA; 3-Methyladenine; ACC; Acetyl-CoA Carboxylase; Ad; adenoviruses; AKT; Protein Kinase B, also known as AKT; AMPK; Adenosine 5â²-monophosphate (AMP)-activated protein kinase; AT
Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis
Keywords: غالب منفی است; Obesity; Lipid metabolism; Inflammation; AAV8; adeno-associated virus serotype 8; Abcd1; ATP binding cassette subfamily D member 1; Acadl; acyl-CoA deshydrogenase, long-chain; Acadm; acyl-CoA deshydrogenase, medium chain; ACC; acetyl-CoA carboxylase; Acox
Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation
Keywords: غالب منفی است; DA; dominant active; DN; dominant negative; DCIS; ductal carcinoma in situ; ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; ERK; extracellular-signal regulated kinase; ER; estrogen receptor; GAP; GTPase activating protein; GFP; green
Differential roles of PKC isoforms (PKCs) in GnRH stimulation of MAPK phosphorylation in gonadotrope derived cells
Keywords: غالب منفی است; GnRH; PKCα; PKCβII; PKCδ; PKCε; MAPK; ERK; JNK; p38; Gonadotropes; LβT2 cells; αT3-1 cells; anti-DP antibodies; anti-diphospho-antibodies; DAG; diacylglycerol; DN; dominant negative; ERK; extracellular signal-regulated kinase; FSH; follicle stimula
Neuronal Transforming Growth Factor beta Signaling via SMAD3 Contributes to Pain in Animal Models of Chronic Pancreatitis
Keywords: غالب منفی است; Pain Signal Transduction; Mouse Model; Neurobiology; Pancreas; BAMBI; Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor; CGRP; calcitonin gene-related peptide; CP; chronic pancreatitis; DiI; 1,1ʹ-dioleyl-3,3,3ʹ,3-tetramethylindocarbocyani
A heterozygous dominant-negative mutation in the coiled-coil domain of STAT1 is the cause of autosomal-dominant Mendelian susceptibility to mycobacterial diseases
Keywords: غالب منفی است; AD-MSMD; autosomal-dominant Mendelian susceptibility to mycobacterial diseases; GAS; gamma-activated sequence; ISRE; IFN-stimulated response element; WT; wild-type; CCD; coiled-coil domain; DBD; DNA-binding domain; PBMC; peripheral blood mononuclear cells
ORAI1-dependent synaptic plasticity in rat hippocampal neurons
Keywords: غالب منفی است; LTP; long term potentiation; cLTP; chemical long term potentiation; CM; conditioning medium; ER; endoplasmic reticulum; STIM; stromal interaction molecule; RyRs; ryanodine receptors; DN; dominant negative; NMDA(R); N-methyl-d-aspartate (receptor); SOCE; s
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: غالب منفی است; Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling
Keywords: غالب منفی است; AD; atopic dermatitis; DFE; Dermatophagoides farinae extract; DN; dominant negative; FSL-1; TLR2/TLR6 agonist, synthetic diacylated lipoprotein; HDM; house dust mite; IKK; IκB kinase; ILC; innate lymphoid cell; LPS; lipopolysaccharide; NOD2; nucleotide-b
RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation
Keywords: غالب منفی است; CA; constitutively active; DMEM; Dulbecco's modified Eagle's medium; DN; dominant negative; GAP; GTPase activating protein; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDF; GDI displacement factor; GDI; guanine nucleotide dissociation inhibitor; GEF;
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Keywords: غالب منفی است; CHC; clathrin heavy chain; CHX; cycloheximide; DN; dominant negative; EEA1; early endosome antigen 1; ERAD; ER-associated degradation; ESCRT; endosomal sorting complex required for transport; Hrg; heregulin; ILVs; intra luminal vesicles; LAMP1; lysosome-a
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury
Keywords: غالب منفی است; Ad; adenovirus; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATF6; activating transcription factor 6; ChIP; chromatin immunoprecipitation; CHOP; C/EBP homologous protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxid
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB
Keywords: غالب منفی است; CA; constitutively active; DMEM; Dulbecco's modified Eagle's medium; DN; dominant negative; GAP; GTPase activating protein; GDF; GDI displacement factor; GDI; guanine nucleotide dissociation inhibitor; GEF; guanine nucleotide exchange factor; GSH; glutath
Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell
Keywords: غالب منفی است; Cobalt chloride; Gastric epithelial cell; HIF1α; Hypoxia; p300; PKC; CoCl2·6H2O; Cobalt chloride hexahydrate; DAG; Diacylglycerol; DAPI; 4â²,6-Diamidino-2-Phenylindole, Dilactate; DN; Dominant negative; GECs; Gastric epithelial cells; HDAC1; Histone-de
Research paperN-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations
Keywords: غالب منفی است; AJ; adherens junction; CAFs; cancer-associated fibroblasts; CNS; central nervous system; DN; dominant negative; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; FA; focal adhesion; FGF; fibro
Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction
Keywords: غالب منفی است; EC; endothelial cells; ROS; reactive oxygen species; NO; nitric oxide; eNOS; endothelial NO synthase; PP1; protein phosphatase 1; AMPK; AMP-activated protein kinase; PKC; protein kinase C; PP2A; protein phosphatase 2A; CRIK; citron Rho-interacting kinase;
Neuroscience Forefront ReviewThe complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
Keywords: غالب منفی است; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CNS; central nervous system; CNTF; ciliary neurotrophic factor; Cx43; connexin 43; DN; dominant negative; EGF; epidermal growth factor; ETC; electron transport chain; GFAP; glial fibrillary ac
NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis
Keywords: غالب منفی است; Apoe; Apolipoprotein e; CTGF; Connective tissue growth factor; CNN; Calponin; DN; Dominant negative; ECM; Extracellular matrix; FBS; Foetal bovine serum; HG; High glucose; LCA; Left common carotid artery; mRNA; Messenger ribonucleic acid; MASM; Mouse Aort
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events
Keywords: غالب منفی است; CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; PAK; p21-activated kinases; SFK; Src family of kinases; PKC; protein kinase C; PYK2; proline-rich tyrosine kinase 2; FAK; focal adhesion kinase; SHC; Src homolog
C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells
Keywords: غالب منفی است; GM; growth medium; DM; differentiation medium; GEF; guanine nucleotide exchange factor; MHC; myosin heavy chain; CBR; Crk binding region; ShRNA; small hairpin RNA; FAs; focal adhesions; SFK; Src family kinase; Cl-casp-3; cleaved caspase-3; Dn; dominant ne
Novel large deletion in the ACTA1 gene in a child with autosomal recessive nemaline myopathy
Keywords: غالب منفی است; Nemaline myopathy; ACTA1; Deletion; Dominant negative; Loss of function;
CK2 accumulation at the axon initial segment depends on sodium channel Nav1
Keywords: غالب منفی است; Protein kinase CK2; Nav1; Phosphorylation; Phosphospecific antibody; Dominant negative; Axon initial segment;
GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells
Keywords: غالب منفی است; Aβ; amyloid beta peptide; AD; Alzheimer's disease; ADAM; A disintegrin and metalloproteinase; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; beta-secretase; CHO; Chinese hamster ovary; CTF; C-terminal fragment; DN; dominant negative; FA
Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells
Keywords: غالب منفی است; GEF; guanine nucleotide exchange factor; T-CVID; T cell type common variable immunodeficiency; B-CLL; B-cell chronic lymphocytic leukemia; shRNA; short-hairpin RNA; SDS-PAGE; SDS-polyacrylamide gel electrophoresis; GST; Glutathione S-transferase; PAK1; p2
Research ArticleCardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation
Keywords: غالب منفی است; CT-1; Cardiotrophin-1; rCT-1; recombinant CT-1; NAFLD; non-alcoholic fatty liver disease; HFD; high fat diet; FA; fatty acid; ER; endoplasmic reticulum; DN; dominant negative; AMPK; AMP-activated protein kinase; SIRT1; sirtuin1; TG; triacylglycerol; NASH;
OxLDL induces endothelial dysfunction and death via TRAF3IP2: Inhibition by HDL3 and AMPK activators
Keywords: غالب منفی است; ACh; acetylcholine chloride; Act1; NF-κB activator 1; AP-1; activator protein-1; AICAR; 5-aminoimidazole-4-carboxamide-1-(R)-d-ribonucleoside; AMPK; 5׳-adenosine monophosphate-activated protein kinase; CIKS; connection to IKK and stress-activated protei
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives
Keywords: غالب منفی است; Heart; MAPK; Cardiac diseases; Mitochondria; Cell signaling; AngII; angiotensin II; CA; constitutively active; CHIP; C terminus of Hsc70-interacting protein; CT-1; cardiotrophin-1; ÎΨmit; mitochondrial membrane potential; DN; dominant negative; ERK1/2;
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser116 signaling cascade in endothelial cells and mice
Keywords: غالب منفی است; eNOS; endothelial nitric oxide synthase; CDK5; cyclin-dependent kinase 5; JNK; c-Jun N-terminal kinase; Abl; Abelson kinase; SH-PTP; SH2 domain-containing protein tyrosine phosphatase; VPA; valproic acid; HDAC; histone deacetylase; HUVEC; human umbilical
5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells
Keywords: غالب منفی است; 5-LO; 5-lipoxygenase; AC; apoptotic cell(s); CV; control virus; d/n; dominant negative; F5; fraction 5; FF; firefly; FLAP; 5-LO activating protein; LC; living cell(s); LR; lipid raft(s); Luc; luciferase; M; marker; MΦ; macrophage(s); mÃCDT; methyl-Ã-cy
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
Keywords: غالب منفی است; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ATF4; activating transcription factor 4; ca; constitutively active; dn; dominant negative; ERK; extracellular signal-related protein kinase; FBS; fetal bovine serum; GCN2; general control non-dere
Rit subfamily small GTPases: Regulators in neuronal differentiation and survival
Keywords: غالب منفی است; CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega
Lysophosphatidic acid induces increased BACE1 expression and Aβ formation
Keywords: غالب منفی است; AD; Alzheimer's disease; NFT; neurofibrillary tangles; Aβ; β amyloid; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; oxLDL; oxidized low-density lipoprotein; CSF; cerebrospinal fluid; LPA; lysophosphatidic acid; CREB; cAMP respons
Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling
Keywords: غالب منفی است; AGE; advanced glycation end product; AOPP; advanced oxidation protein product; AP-1; activator protein-1; CD36; cluster determinant 36; CRP; C-reactive protein; dn; dominant negative; CuZnSOD; copper/zinc superoxide dismutase; DPI; diphenylene iodonium; G
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB
Keywords: غالب منفی است; SPHK1; Sphingosine kinase 1; SPL; Sphingolipid; S1P; Sphingosine 1-phosphate; HMBA; Hexamethylene bisacetamide; WT; Wild-type; DN; Dominant negative; EMSA; Electrophoresis mobility shift assay; ChIP; Chromatin immunoprecipitation; Friend cell; SPHK1; c-MY
CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction
Keywords: غالب منفی است; Act1; activator of NF-κB; AOPPs; advanced oxidation protein products; AGE; advanced glycation end product; AP-1; activator protein-1; C/EBP; CCAAT/enhancer-binding protein; CIKS; connection to IKK and SAPK/JNK; DCFH-DA; 2â²,7â²-dichlorofluorescin-diace
ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics
Keywords: غالب منفی است; Nucleotide pool; ITPA gene polymorphism; Pharmacogenetics; Base analogs; Mercaptopurines; Protein stability; Dominant negative; ITPA; inosine triphosphate pyrophosphatase; ITP; inosine triphosphate; XTP; xanthosine triphosphate; HAM1; Saccharomyces cerevi
A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome
Keywords: غالب منفی است; ECG, electrocardiogram; IKr, delayed rectifier K+ current; LQT2, long QT syndrome type 2; LQTS, long QT syndrome; QTc, corrected QT; TdP, torsades de pointesLong QT syndrome; KCNH2; Nonpore region; Trafficking deficient; Dominant negative
Ubiquitin tagged dominant negative induces degradation of B-ZIP proteins
Keywords: غالب منفی است; B-ZIP domain; basic leucine zipper domain; CREB; CRE-binding protein; VBP; vitellogenin gene-binding protein; C/EBP; CAAT/enhancer binding protein; AP1; activator protein 1; B-ZIP domain; Ubiquitin; Trans; A-ZIP; Dominant negative;
BMP signaling is responsible for serum-induced Id2 expression
Keywords: غالب منفی است; BMP; bone morphogenetic protein; BRE; BMP-responsive element; ChIP; chromatin immunoprecipitation; R-Smad; receptor-regulated Smad; Co-Smad; common-partner Smad; FBS; fetal bovine serum; TGF-β; transforming growth factor-β; dn; dominant negative; Serum;
Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages
Keywords: غالب منفی است; APC; antigen presenting cell; BMM; bone marrow derived macrophages; DMSO; dimethyl sulfoxide; DN; dominant negative; GSI; gamma secretase inhibitor; IFN; interferon; LPS; lipopolysaccharide; MAML; Mastermind-like; NIC; intracellular Notch1; PAMP; pathogen
The Drosophila larva as a tool to study gut-associated macrophages: PI3K regulates a discrete hemocyte population at the proventriculus
Keywords: غالب منفی است; Haemocyte; Gut; Intestine; Innate immunity; Insect; Migration; Phagocytosis; PV; proventriculus; L3W; L3 wandering larvae; DH31; diuretic hormone 31; PI3K; phosphoinositide 3-kinase; DN; dominant negative; CA; constitutively active;
Neural activity and branching of embryonic retinal ganglion cell dendrites
Keywords: غالب منفی است; RGC; retinal ganglion cell; KV; voltage-gated potassium; WT; wildtype; DN; dominant negative; BMP-2; bone morphogenetic protein-2; NAA; neurofilament associated antigen; Kir; inward rectifier potassium; Xenopus laevis; Retina; Dendritogenesis; In vivo; Po
CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy
Keywords: غالب منفی است; Act1; activator of NF-κB; ACM; adult cardiomyocytes; ANF; atrial natriuretic factor; AP-1; activator protein-1; AT1; angiotensin II type 1 receptor; ATRAP; AT1-receptor-associated protein; ARAP1; type 1 Ang II-receptor-associated protein 1; C/EBP; CCAAT/