Ubiquitin tagged dominant negative induces degradation of B-ZIP proteins

► The dominant negative designs termed A-ZIPs heterodimerize with B-ZIPs. ► We designed a chimeric protein with two ubiquitin motifs at the N-terminal of A-ZIP. ► It results in degradation of B-ZIP heterodimerization partners more efficiently. ► This process of enhanced degradation is inhibited by proteasome inhibitor MG-132.