Lysophosphatidic acid induces increased BACE1 expression and Aβ formation

► Evidence suggests that vascular factors play an important role in pathogenesis of AD. ► First, we found that LPA induces increased production of Aβ. ► Second, LPA induces increased Aβ production via upregulating β-secretase expression. ► Third, PKCδ is involved in LPA-induced β-secretase expression and Aβ production. ► Cardiovascular risk factors may contribute to AD by increasing Aβ production.