Keywords: Estrogen-related receptor α; APP/PS1 mice; Amyloidogenesis; Tau phosphorylation; Aβ; amyloid protein; AD; Alzheimer's disease; ADAM10; a disintegrin and metalloproteinase 10; AMPK; AMP-activated protein kinase; APP; β-amyloid precursor protein; APP/PS1
مقالات ISI (ترجمه نشده)
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Keywords: Alzheimer's disease dementia; BACE1; β-secretase; Biomarker diagnosis; Mild cognitive impairment; Prediction;
Keywords: Hydrogen sulfide; Gasotransmitter; Sulfhydration; Neurodegeneration; Oxidative stress; Antioxidants; 3-MST; 3-mercaptopyruvate sulfurtransferase; 4-HNE; 4-hydroxynonenal; 6-OHDA; 6-hydroxydopamine; Aβ; β-Îmyloid; AD; Alzheimer's disease; ALS; Amyotro
Keywords: Alzheimer's disease; BACE inhibitor; BACE1; Dendritic spines; On-target side effects; Synaptic plasticity;
Keywords: Alzheimer's disease; BACE1; Antioxidant; Metal chelator; Docking; Multi-target ligand design; Cell-based toxicity assay;
Keywords: AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid precursor protein; BACE1; β-amyloid cleavage enzyme 1, β-secretase 1; GSM; gamma secretase modulator; LHS; left hand side; NSAID; non-steroidal anti-inflammatory drug; SAR; structure activ
Keywords: Alzheimer's Disease; Beta-secretase; BACE1; Transmembrane helix; Transmembrane domain; Helix packing; Trimer; Copper; Metal ion; Sulfur; Methionine; Cysteine; Channels and transporters; Molecular dynamics; MD simulations;
Keywords: Aβ1-42; 42-amino acid-long Aβ peptide; AD; Alzheimer's disease; ADAPT; Alzheimer's Disease Anti-Inflammatory Prevention Trial; ADAS-Cog; Alzheimer's Disease Assessment Scale-Cognitive Subscale; ADCS-ADL; Alzheimer's Disease Cooperative Study Activ
Keywords: β-CTF; APP beta C-terminal fragment; AA; arachidonic acid; AD; Alzheimer's Disease; APP; Amyloid Precursor Protein; BACE1; beta secretase 1; CE; esterified cholesterol; CHOL; free cholesterol; CNS; central nervous system; COX-2; cyclooxygenase-2; Cyp1b
Keywords: Lycopene; Amyloidogenesis; Cognitive impairments; Neuroinflammation; Oxidative stress; MAPKs /NFκB/ Nrf2 signaling pathways; LYC; Lycopene; LPS; Lipopolysaccharide; AD; Alzheimer's disease; PD; Parkinson's disease; CNS; Central nervous system; Aβ; A
Keywords: Alzheimer's disease; Heavy metals; Berberine; Amyloid-β40/42; Tau protein; Proinflammatory cytokines and In silico analysis; AChE; acetylcholinesterase; AD; Alzheimer's disease; Akt; Protein kinase B; AMPK; 5Ⲡadenosine monophosphate-activated protein
Keywords: Alzheimer's disease; Polyphenol; Ionophoric compound; Amyloid-beta aggregation; Multi-target compound; Reactive oxygen species; Antioxidant; BACE1; Tetrahymena; β-secretase inhibitor; Molecular design; Docking;
Synthesis and biological evaluation of quinazolinone-based hydrazones with potential use in Alzheimer's disease
Keywords: Quinazolinone; BACE1; Alzheimer's disease; Schiff base; Hydrazone; β-Secretase;
Keywords: ABAD; Aβ binding alcohol dehydrogenase; AD; Alzheimer's disease; ADAM; A Disintegrin and metalloproteinase; AICD; APP intracellular domain; APH1; anterior pharynx-defective 1; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ; amyloid be
Keywords: 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: AD; Alzheimer's disease; ANOVA; analysis of variance; APP; beta-amyloid precursor protein; Aβ; beta-amyloid; BACE1; beta-secretase 1; BCA; bicinchoninic acid; COX-2; cyclooxygenase-2; ELISA; enzyme-linked immunosorbent assay; ICS II; icariside II; ICV;
Keywords: Multi-target screening; BACE1; Ensemble docking; Phytochemicals; Anti-amyloidogenic; Antioxidant;
Keywords: 4-DP; 4â²-deoxypridoxine; ABC transporter; ATP-binding cassette transporter; Akt; protein kinase B; ALF4; tetrafluoroaluminate; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; ASM; acid sphingomyelinase; BACE1; beta-site APP-cleaving e
Keywords: Glycosyltransferases; ErbB; TGF-β receptor; BACE1; GLUT2; α5β1 Integrin; BACE1; β-site APP cleaving enzyme, β-secretase; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; Fut8; α1,6 fucos
Keywords: Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: AD; Alzheimer's disease; ADCA; autosomal dominant cerebellar ataxia; AMPA receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; Atx2mut; mutant ataxin-2; Aβ peptides; amyloid beta peptides; BACE1; beta
Keywords: Curcumin; BACE1; Alzheimer's disease; Structure-activity relationship;
Keywords: AAV; adeno-associated virus; Aex; ascites-derived exosomes; BACE1; beta secretase 1; BAP-TM; biotin acceptor peptide-transmembrane domain; CAM; cell adhesion molecule; CD; cluster of differentiation; CD; cytosine deaminase; Dex; dendritic cell-derived exo
Keywords: ABC; ATP binding cassette; ADP; Adenosine-5â²-diphosphate; AMP; Adenosine-5â²-monophosphate; AMPPNP; Adenosine-5â²-(β,γ-imido)triphosphate; ATP; Adenosine-5â²-triphosphate; BACE1; β-Site amyloid precursor protein cleaving enzyme 1; BPM; Biophysical
Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; AICD; APP intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP; amyloid β precursor protein; Apo E; apolipoprotein E; BACE1; β-site APP converting enzyme 1; BDNF; brain derive
Keywords: Ageing; Aβ levels; IDE; BACE1; JNK1; Hippocampus; SAMP8;
Keywords: 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c
Keywords: β-secretase; BACE1; Alzheimer’s disease; Protonation state; Molecular dynamic simulation; Molecular docking
Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
Keywords: BACE1; Sphingomyelin; Amyloid-β; Lysosomal degradation; Alzheimer's disease; Lipids;
(â)-Pteroside N and pterosinone, new BACE1 and cholinesterase inhibitors from Pteridium aquilinum
Keywords: Pteridium aquilinum; Bracken; Seco-illudoid; BACE1; Cholinesterase;
Moracin derivatives from Morus Radix as dual BACE1 and cholinesterase inhibitors with antioxidant and anti-glycation capacities
Keywords: Morus alba; Moracins; BACE1; Alzheimer's disease; Drug design;
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Keywords: Aβ; amyloid β; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; APP; amyloid precursor protein; BACE1; beta-secretase 1; BSA; bovine serum albumin;
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures
Keywords: BACE1; Hyperphosphorylated tau; Excitotoxicity; cPLA2; Desaturases; Inflammation;
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy
Keywords: Alzheimer's disease; Ginseng; Autophagy; BACE1; ER stress; Amyloid β; Apoptosis; APP/PS1 transgenic mice;
The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells
Keywords: AD; Alzheimer's disease; BACE1; β-secretase or β-site amyloid precursor protein cleaving enzyme 1; Aβ; β-amyloid peptide; APP; amyloid precursor protein; COS; chitosan oligosaccharides; MTT; 3-[4,5-dimethylthiazol-2-yl]- 2,5- diphenyltetrazolium bro
PERK as a hub of multiple pathogenic pathways leading to memory deficits and neurodegeneration in Alzheimer's disease
Keywords: Alzheimer's disease; PERK; eIF2α; Translation; BACE1; Aβ; Tau; Learning and memory;
Identification of a novel antisense long non-coding RNA PLA2G16-AS that regulates the expression of PLA2G16 in pigs
Keywords: NATs; natural antisense transcripts; PLA2G16; phospholipase A2 group XVI; lncRNAs; long non-coding RNAs; VIM; vimentin; VIM-AS1; VIM antisense transcript1; BACE1; β-site APP-cleaving enzyme 1; BACE1-AS; BACE1 antisense transcript; PLA2G16-AS; PLA2G16 ant
Reduced retromer function results in the accumulation of amyloid-beta oligomers
Keywords: AF700; AlexaFluor-700; AD; Alzheimer's disease; Aβ; Amyloid beta; oAβ; Amyloid beta oligomers; APP; Amyloid precursor protein; BACE1; Beta-secretase 1; BDNF; Brain-derived neurotrophic factor; cDNA; Complementary DNA; CSF; Cerebrospinal fluid; EEA1; Ear
Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ1-42
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APC; antigen-presenting cell; BACE1; β-site APP cleaving enzyme 1; BBB; blood-brain barrier; CCK; cell-counting kit; CD40; cluster of differentiation 40; CNS; central nervous system; DAPI; 4â²,6-diamidino-
G-score: A function to solve the puzzle of modeling the protonation states of β-secretase binding pocket
Keywords: G-score; Population density; Molecular dynamics; GROMACS; BACE1; Reduced amide; Tertiary carbinamine; Hydroxyethylamine; Protonation state; Alzheimer; TMoLiC;
Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations
Keywords: Aβ; amyloid β; ADME; absorption distribution metabolism and excretion; ADT; AutoDockTool; APP; amyloid precursor protein; AD; Alzheimer's disease; BACE1; β-site amyloid precursor protein cleaving enzyme 1; n-BuOH; n-butanol; CH2Cl2; dichloromethane;
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
Keywords: BACE1; CREB; insulin resistance; NF-κB; palmitate; PGC-1α; sAPPβ;
Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet
Keywords: Aβ; β-amyloid; Aβ1-40; β-amyloid1-40; Aβ1-42; β-amyloid1-42; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-site amyloid precursor protein cleaving enzyme 1; BDNF; brain-derived neurotrophic factor; DHA; docosahexaenoic acid; DHA
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease
Keywords: Alzheimer disease; BACE1; Bilivedin reductase-A; Canine; Dog; Insulin resistance;
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice
Keywords: Alzheimer's disease; Amyloid β peptide; BACE1; IL-6; Oxidative stress; Phloroglucinol; TNF-α;
Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3â¯Ãâ¯Tg-AD mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Cerebrovascular basement membrane; Microglia; BACE1; Antioxidants; Oxidative stress;
Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease
Keywords: AD; Alzheimer disease; Aβ; β-amyloid; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10/α-secretase (brain); APP; Amyloid Protein Precursor; APOE ε4; Apolipoprotein, allele epsilon4; BACE1; beta-site amyloid precursor protein cl