Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model

► Propranolol attenuated cognitive memory impairments in SAMP8 mice in NORT. ► SAMP8 show increases in Aβ42 levels and BACE1 expression and decreased IDE expression. ► Increases in pTau related to a decrease in JNK1 expression were shown by SAMP8 mice. ► SAMP8 mice displayed synaptic pathology, as shown by decreases in synaptophysin and BDNF. ► Amyloid, Tau and synaptic pathology in SAMP8 mice all reversed by propranolol.