Keywords: HHC; Human Hepatocellular Carcinoma; LCSLC; sliver cancer stem-like cells; TRPV2; Transient Receptor Potential Vanilloid-type 2 channel; TRP; Transient Receptor Potential; SCID; severe combined immunodeficiency; ALDH1; aldehyde dehydrogenase 1; GFP; green
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Keywords: Diabetic cardiomyopathy; Curcumin; Autophagy; Apoptosis; Beclin1; 3-MA; 3-methyladenine; 4E-BP1; 4E-binding protein 1; AMPK; 5â² adenosine monophosphate -activated protein kinase; BH; Bcl-2-homology; CC; AMPK inhibitor compound C; mTOR; mammalian target
Keywords: PGMO; Pre-gestational maternal obesity; PGMN; Pre-gestational maternal normal weight; HUVECs; Human umbilical vein endothelial cells; NO; Nitric oxide; NOS; Nitric oxide synthase; eNOS; endothelial nitric oxide synthase; Akt; Protein kinase B/Akt; ER; end
Keywords: Nicotine; Hippocampus; Extinction; ERK1/2; JNK1;
Keywords: Apoptosis; Calcium influx; JNK1; Oxidative stress; Protein kinase C; Tamoxifen
Keywords: AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: APAP; Acetaminophen; AP-1; Activator protein 1; ASK1; Apoptosis signaling kinase; BMD; Benchmark dose; BMDL; Lower confidence limit of benchmark dose; BrdU; Bromodeoxyuridine; bw; Body weight; JNK1; c-Jun NH2-terminal kinase 1; CT; Carbon tetrachloride; B
Keywords: Gases; Neuroprotective effect; Mechanism; Clinical translation; Research perspectives; AD; Alzheimer's disease; AMPA; alpha-amino-d-hydroxy-5-methyl-4-isoxazole-propionate; Ar; argon; ATA; absolute atmosphere; ATP; adenosine triphosphate; BBB; blood-bra
Keywords: Ageing; Aβ levels; IDE; BACE1; JNK1; Hippocampus; SAMP8;
The isoflavones and extracts from Maclura tricuspidata fruit protect against neuronal cell death in ischemic injury via induction of Nox4-targeting miRNA-25, miRNA-92a, and miRNA-146a
Keywords: FME50; 50% EtOH extract of Maclura tricuspidata fruits; CFI; cudraisoflavone I; CFH; cudraisoflavone H; Nox; NADPH oxidase; OGD/Râ¯+â¯glucose; oxygen-glucose deprivation/reoxygenationâ¯+â¯glucose; MCAO/R; middle cerebral artery occlusion/reperfusion;
Identification of JNK1 as a predicting biomarker for ABT-199 and paclitaxel combination treatment
Keywords: Paclitaxel; ABT-199; Combination; JNK1; Biomarker;
JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice
Keywords: Compensatory hypertrophy; Small-for-size syndrome; Future liver remnant; Hedgehog; JNK1;
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Src-family tyrosine kinases and the Ca2Â + signal
Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr
Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway
Keywords: NaF; Sodium; ROS; Reactive oxygen species; O2â¢â; superoxide; GSH; Glutathione; MDA; Malondialdehyde; Bax; Bcl2-associated X protein; Bcl-2; B-cell CLL/lymphoma 2; GAPDH; Glyceraldehyde-3-Phosphate Dehydrogenase; COXIV; Cytochrome C Oxidase Subunit IV;
Inhibitory effects of shRNA on expression of JNK1 and migration and invasion in mouse hepatocellular carcinoma cell lines mediated by ultrasound-targeted microbubble destruction
Keywords: Ultrasound microbubble; Hepatocellular carcinoma; JNK1; shRNA; Transfection; Lymphatic metastasis
Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
Keywords: SIRT1; silent mating type information regulation 2 homolog 1; PPARγ; peroxisome proliferator-activated receptor γ; LPS; lipopolysaccharide; MKP-7; mitogen-activated protein kinase phosphatase-7; PGC-1α; peroxisome proliferator-activated receptor gamma
Inhibition of endoplasmic reticulum stress and oxidative stress by vitamin D in endothelial cells
Keywords: CSPD; 3-(diethylamino)-1-(2,2-dimethyl-3-H-1-benzofuran-7-yl)-propan-1-one; eIF2α; eukaryotic initiation factor 2α; DMSO; dimethylsulfoxide; EB; EB1089; ER; endoplasmic reticulum; ES-TRAP; placental secreted alkaline phosphatase; GAPDH; glyceraldehyde-3
ReviewIL-6 pathway in the liver: From physiopathology to therapy
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Fc; constant portion of an IgG antibody; gp130; glycoprotein 130Â kDa; IL; interleukin; JAK1; Janus kinase 1; JNK1; Jun amino-terminal kinase 1; LPS; lipopolysaccharide; R; receptor; s;
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation
Keywords: mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti
c-Jun NH2-teminal kinase 1 interacts with vitamin D receptor and affects vitamin D-mediated inhibition of cancer cell proliferation
Keywords: JNK1; c-Jun NH2-terminal kinases 1; VDR; vitamin D receptor; MEF; mouse embryonic fibroblast; JNK1; Vitamin D receptor; Cancer;
Research ArticleHaematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury
Keywords: HCC; hepatocellular carcinoma; NEMOÎhepa; NEMO knockout mice; ConA; concanavalin A; AP; alkaline phosphatase; GS; glutamine synthetase; ALT; alanine aminotransferase; DEN; diethylnitrosamine; Jnk1; Jnk2; Necrosis; Apoptosis; IKKγ/NEMO; HCC;
Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis
Keywords: Atherosclerosis; Hypercholesterolemia; Proteasome; JNK1; AP-1; Vitamin EAP-1, activator protein-1; CD36, cluster of differentiation 36; ERAD, endoplasmic-reticulum-associated protein degradation; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; JNK, c-Jun
T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28â T cells
Keywords: mTOR; mammalian target of rapamycin; mTORC1/2; mTOR complex 1/2; TCR; T cell receptor; CMV; cytomegalovirus; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; PDK; phosphoinositide-dependent protein kinase 1; S6K1; S6 kinase 1; 4E-BP1; 4E-binding pr
eNOS-JNK1-AR signaling pathway mediates deltamethrin-induced germ cells apoptosis in testes of adult rats
Keywords: Deltamethrin; Apoptosis; Spermatogenesis; eNOS; JNK1; Androgen receptor
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Sirtuin1 and autophagy protect cells from fluoride-induced cell stress
Keywords: AMPK; AMP-activated protein kinase; Atg; autophagy related gene; CR; caloric restriction; eIF2α; eukaryotic initiation factor-2, subunit alpha; ER; endoplasmic reticulum; HF; hydrogen fluoride; JNK1; c-Jun N-terminal kinase-1; LS8; ameloblast-derived cel
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua
Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells
Keywords: Simvastatin (PubChem CID:54454); Bay11-7082 (PubChem CID:5353431); Farnesyl pyrophosphate (PubChem CID:445713); Geranylgeranyl pyrophosphate (PubChem CID:447277); SP600125 (PubChem CID:8515)Simvastatin; NFκB stability; Pin1; JNK1; AP-1; MMP-2/MMP-9
MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells
Keywords: miRNA; microRNA; miR-214; microRNA-214; IC50; inhibit concentration 50; UTR; untranslated region; EGFP; enhanced green fluorescence protein; HA; hemagglutinin; 5-aza-CdR; 5-aza-deoxycytidine; TSA; trichostatin A; Bcl2l2; BCL2-like 2; MEK3; MAPK/ERK kinase
Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors
Keywords: Pyrazoles; Heterocycles; Microwaves; P38 MAPK; JNK1;
Autophagy, polyphenols and healthy ageing
Keywords: AD; Alzheimer's disease; AMP; adenosine monophosphate; AMPK; adenosine monophosphate activated protein kinase; APP; amyloid beta precursor protein; Atg; autophagy (related gene); ATP; adenosine triphosphate; AV; autophagic vacuoles; Aβ; amyloid beta; Bcl
Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways
Keywords: MCH; Liver; Lipid Metabolism; White Adipose Tissue; ACCα; acetyl-CoA carboxylase α; ARC; arcuate nucleus of the hypothalamus; CIDEA; cell death-inducing DNA fragmentation factor alpha-like effector A; CNS; central nervous system; FAS; fatty acid synthas
The role of pseudokinases in cancer
Keywords: ALL; Acute Lymphoblastic Leukaemia; AML; Acute Myeloid Leukaemia; AMPK; 5â²-Adenosine Monophosphate Activated Protein Kinase; ATF4; Activating Transcriptional Factor 4; ATP; Adenosine-5â²-Triphosphate; BTICs; Brain Tumour-Initiating Cells; C/EBPα; CCAA
Effects of sub-chronic nandrolone administration on hormonal adaptive response to acute stress in rats
Keywords: Nandrolone decanoate; Acute stress; HPAA; Serotonin re-uptake; ERK1/2; JNK1;
Autophagy and polyglutamine diseases
Keywords: HD; Huntington's disease; SCA; spinocerebellar ataxia; DRPLA; Denatorubral-pallidoluysian atrophy; SBMA; spinal and bulbar muscular atropy; Htt; Huntingtin; UPS; ubiquitin-proteasome system; HDL-2; Huntington's disease-like 2; IBs; inclusion bodies; RNA
Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein
Keywords: app; apparent; DHA; dehydroalanine; FA; formic acid; GPX1; glutathione peroxidase-1; GSH; glutathione; GSSG; glutathione disulfide; IDA; information-dependent acquisition; JNK1; c-Jun NH2-terminal protein kinase 1; LC; liquid chromatography; MRM; multiple
Glyoxalase in tumourigenesis and multidrug resistance
Keywords: AGE; advanced glycation endproduct; ALL; acute lymphoid leukaemia; AML; acute myeloid leukaemia; BBGD; S-p-bromobenzylglutathione cyclopentyl diester; CEdG; N2-(1-carboxyethyl)-deoxyguanosine; CEL; NÉ-carboxyethyl-lysine; CrML; chronic myeloid leukaemia;
Chemical modifications of resveratrol for improved protein kinase C alpha activity
Keywords: PKC; protein kinase C; DAG; diacylglycerol; TPA; 12-O-tetradecanoylphorbol-13-acetate; PDB; protein data bank; NMR; nuclear magnetic resonance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HEK; human embryonic kidney; PDS; 4,4â²-dip
c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells
Keywords: Cordycepin; Colon cancer cells; JNK1; G2/M-phase cell-cycle arrest; p21WAF1; Cell growth inhibition
Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors
Keywords: JNK1; JNK2; JIP1; DJNKI; Allosteric kinase inbhibitors
Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca2+-evoked activation of p38α MAPK and JNK1
Keywords: Arachidonic acid; Apoptosis; p38α MAPK; JNK1; Mitochondrial alteration; Reactive oxygen species
JNK1, a potential therapeutic target for hepatocellular carcinoma
Keywords: JNK1; HCC; Signature genes; ROS; Progenitor cells; Epigenetics;
Protective actions of ovarian hormones in the serotonin system of macaques
Keywords: Serotonin; Estrogen; Progesterone; Neuroprotection; Apoptosis; JNK1; Apoptosis-inducing factor; Mitochondria; TUNEL; Laser capture
Role of NonO–histone interaction in TNFα-suppressed Prolyl-4-hydroxylase α1
Keywords: Inflammation; Histone; P4Hα1; TNFα; NonO; JNK1
SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling
Keywords: Parkinson's disease; MPP+; SAG; JNK1; SH-SY5Y human neuroblastoma; Cell viabilityMPP+, 1-methyl-4-phenylpyridinium ion; MPTP, 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine; PD, Parkinson's disease; SAG, sensitive to apoptosis gene; JNK1, c-Jun N-terminal k
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
Keywords: Aminopyrimidines; JNK1; JNK2
JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo
Keywords: JNK1; p21; Sulindac; Proliferation; Apoptosis