دانلود مقالات ISI درباره Bace1 + ترجمه فارسی

Liposome-chaperoned cell-free synthesis for the design of proteoliposomes: Implications for therapeutic delivery

Keywords: ABC; accelerated blood clearance; AUC; area under the curve; BACE1; β-site APPcleaving enzyme 1; C8bp; C8-binding protein; Cardiolipin; 1,3-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol; CDH2; N-cadherin; CF; cell-free; CHO; Chinese Hamster Ovary ce

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

The chemistry and pharmacology of Ligularia przewalskii: A review

Keywords: A375; human melanoma cells; ABTS; 2,2'-azinobis (3-ethylbenzothiazoline-6- sulfonic acid); AChE; acetylcholinesterase; AD; Alzheimer's disease; AGEs; advanced glycation endproducts; B16F10; mouse skin melanoma; BACE1; β-site amyloid precursor cleavin

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2018 سفارش ترجمه

The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer's disease

Keywords: AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; Aβ; amyloid β peptides; ApoE; apolipoprotein E; APP; amyloid precursor proteins; BACE1; β-site APP cleaving enzyme 1; BIN1; bridging integrator 1; CBP; CREB-binding protei

دانلود رایگان متن کامل مقاله ISI 146 صفحه سال انتشار : 2018 سفارش ترجمه

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors

Keywords: Alzheimer; BACE1; Carbazole; Sulfonamides; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer's therapy

Keywords: BACE1; β-secretase responsible for amyloid-β (Aβ) generation in the brain; BBB; blood−brain barrier; Caco-2; human epithelial colorectal adenocarcinoma cells; C; chitosan coated nanoparticles; CNS; central nervous system; CPPs; cell-penetrating pepti

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10

Keywords: Alzheimer's disease; Amyloid precursor protein; MTERF4; ADAM10; BACE1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

Keywords: Pueraria lobata; BACE1; Lupeol; Lupenone; Molecular docking; Kinetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Dual inhibition of BACE1 and Aβ aggregation by β-ecdysone: Application of a phytoecdysteroid scaffold in Alzheimer's disease therapeutics

Keywords: AD therapeutics; BACE1; Aβ aggregation; Steady-state and time-resolved fluorescence; Molecular modeling; AFM;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperEffects of phenothiazine-structured compounds on APP processing in Alzheimer's disease cellular model

Keywords: Alzheimer's disease; Amyloid-β peptide; Cholinesterase inhibitor; Phenothiazine; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ACh; acetylcholine; AChE; acetylcholinesterase; BACE1; β-site APP-cleaving enzyme 1; BChE; butyryl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research ArticleComparative QSAR studies using HQSAR, CoMFA, and CoMSIA methods on cyclic sulfone hydroxyethylamines as BACE1 inhibitors

Keywords: BACE1; AD; HQSAR; CoMFA; CoMSIA;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Berberine modulates amyloid-β peptide generation by activating AMP-activated protein kinase

Keywords: Alzheimer's disease; Berberine; AMP-activated protein kinase; Amyloid-β; β-site APP cleaving enzyme-1; AD; Alzheimer's disease; Aβ; Amyloid-β; APP; Amyloid precursor protein; AMPK; AMP-activated protein kinase; BACE1; β-site APP cleaving enzyme-1; β

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Increased BACE1 activity inhibits peripheral nerve regeneration after injury

Keywords: WT; Wild type; Tg; Transgenic; BACE1; Beta-amyloid cleaving enzyme 1; APP; amyloid precursor protein; PNS; peripheral nervous system; CMAP; compound muscle action potential; MBP; myelin basic protein; AD; Alzheimer's disease; NF; neurofilament; α-BTX; α

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease

Keywords: MALDI-IMS; matrix assisted laser desorption/ionization imaging mass spectrometry; AD; Alzheimer's disease; ST; sulfatide; NFT; neurofibrillary tangles; Aβ; β-amyloid; CSF; cerebrospinal fluid; BACE1; β-site APP cleavage enzyme 1; PC; phosphatidylcholin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

siRNA delivery using polyelectrolyte-gold nanoassemblies in neuronal cells for BACE1 gene silencing

Keywords: AD; Alzheimer's disease; BACE1; β-site APP cleaving enzyme 1; LbL; Layer-by-layer; PAH-Cit; Citraconic anhydride modified poly (allylamine) hydrochloride; PE-Gold NAs; Polyelectrolyte-gold nanoassemblies; PEI; Polyethyleneimine; PLA; Poly l-arginine; siR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Research ArticlePharmacophore based 3D-QSAR modeling, virtual screening and docking for identification of potential inhibitors of β-secretase

Keywords: BACE1; β-secretase; AD; Alzheimer's disease; Aβ; amyloid-β; BBB; blood brain barrier; PDB; protein data bank; rmsd; root mean square deviation; IC50; inhibitory concentration; β-secretase; Alzheimer's disease; Pharmacophore; Virtual screening; Doc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1

Keywords: Par3; aPKC; BACE1; PACS1; Retrograde trafficking; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Lipoic acid prevents acrylamide-induced neurotoxicity in CD-1 mice and BV2 microglial cells via maintaining redox homeostasis

Keywords: ACR; acrylamide; LA; lipoic acid; CNS; central nervous system; GSH; glutathione; MPO; myeloperoxidase; BDNF; brain derived neurotrophic factor; NGF; nerve growth factor; NT-3; neurotrophin-3; GFAP; glial fibrillary acidic protein; NSF; N-ethylmaleimide se

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Multi-structure docking analysis of BACE1 crystal structures and non-peptidic ligands

Keywords: Multi-structure docking; BACE1; β-Secretase; Non-peptidic inhibitors; Chemometrics methods;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice

Keywords: Rheb; Forebrain; BACE1; Spatial memory; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium

Keywords: Sargassum serratifolium; BACE1; Meroterpenoids; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Keywords: AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein

Keywords: Alzheimer's disease; Amyloid β-protein; Mitochondria; BACE1; γ-secretase; Subcellular fractionation;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease

Keywords: Alzheimer's disease; Berberine; Autophagy; Amyloid-β; BACE1; Spatial cognitive deficits;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

N-glycan and Alzheimer's disease

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme-1; DAP12; DNAX-activating protein of 12 kD; GnT-III; N-acetylglucosaminyltransferase-III; NFT; neurofibrillary tangle; PS

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; ANS; autonomic nervous system; BACE1; beta-site APP-cleaving enzyme 1; BBB; brain blood barrier; CSF; cerebrospinal fluid; DIO; diet-induced obesity; HCD; high calorie diet; H

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice

Keywords: BACE1; beta-site APP-cleaving enzyme 1; miRNAs; microRNAs; miR-124; microRNA-124; Aβ; amyloid-beta; AD; Alzheimer's disease; APP; amyloid precursor protein; DG; dentate gyrus; MTIs; miRNA-target interactions; LC3II; Light Chain 3 II; PVDF; Polyvinylidene

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

Keywords: BACE1; Alzheimer's disease; Blood brain barrier; CNS delivery;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Ethanol-induced PGE2 up-regulates Aβ production through PKA/CREB signaling pathway

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; ROS; reactive oxygen species; ER; endoplasmic reticulum; eIF2α; eukaryotic initiation factor alpha; CHOP; C/EBP-homologous protein; PGE2;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

A PM7 dynamic residue-ligand interactions energy landscape of the BACE1 inhibitory pathway by hydroxyethylamine compounds. Part I: The flap closure process

Keywords: BACE1; Hydroxyethylamine; Flap; PM7; MOPAC; Interaction energy; GROMACS; Molecular dynamics;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells

Keywords: Abs; absorbance; ADAM10; a disintegrin and metalloprotease domain protease 10; AG; aminoguanidine; APP; amyloid precursor protein; Aβ; amyloid β; BACE1; β site APP cleaving enzyme; CCO; cytochrome c oxidase; DDC; diethyldithiocarbamate; DMEM; Dulbecco'

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Multi-functional activities of citrus flavonoid narirutin in Alzheimer's disease therapeutics: An integrated screening approach and in vitro validation

Keywords: Alzheimer's disease therapeutics; Multi-target virtual screening; BACE1; Aβ fibril formation; Anti-oxidant;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Alzheimer's disease: How metal ions define β-amyloid function

Keywords: Aβ1−40; β-Amyloid, 40-residue isoform; Aβ1−42; β-Amyloid, 42-residue isoform; Aβ1−42/Aβ1−40; Ratio between levels of Aβ1−42 and Aβ1−40; ADAM; A Disintegrin And Metalloprotease, zinc peptidases, some being α-secretases; AICD; APP intra

دانلود رایگان متن کامل مقاله ISI 112 صفحه سال انتشار : 2017 سفارش ترجمه

Endogenous APP accumulates in synapses after BACE1 inhibition

Keywords: APP; BACE1; Immunocytochemistry; Synapse; Synaptic vesicle; Proximity ligation assay

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells

Keywords: Ginsenoside Re; Alzheimer´s disease; Aβ; BACE1; PPARγ;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors

Keywords: Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; Amyloid precursor protein; BACE1; β-site amyloid precursor protein cleaving enzyme 1; BBB; Blood-brain barrier; DMF; 5,7-dimethoxyflavone; KP; Kaempferia parviflora; PMF; 3,5,7,3′,4′-pentametho

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera

Keywords: BACE1; Alzheimer's disease; Docking analysis; Enzyme kinetic; Fucosterol; Fucoxanthin; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; BACE1; β site amyloid precursor protein cleaving enzyme 1; BBB; blood-brain barrier; COX-2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Post-translational regulation of the β-secretase BACE1

Keywords: Alzheimer’s disease; Amyloid β-protein; BACE1; β-Secretase; Oligomer; Trafficking

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases

Keywords: Cassia obtusifolia; ChEs; BACE1; Anthraquinones; Molecular docking

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

Keywords: Trisomic mice; BACE1; APP-βCTF; Alzheimer's disease; Endosomes; Basal forebrain cholinergic neurons;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor

Keywords: Alzheimer's disease (AD); β-secretase (BACE1); β-amyloid peptide; Paeonia lactiflora Pall; 4-O-galloylalbiflorin; Docking; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-site amyloid precursor protein cleavin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis

Keywords: Umbelliferone 6-carboxylic acid; Esculetin; Daphnetin; Coumarins; Cholinesterase; BACE1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2

Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APP; beta-amyloid precursor protein; ARE; antioxidant response element; BACE1; β-site APP-cleaving enzyme 1; CBS; cystathionine-β-synthase; DG; dentate gyrus; GST; glutathione S-transferase; HO-1; heme oxygena

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1

Keywords: Electromagnetic pulse; Alzheimer׳s disease; β-amyloid protein; Oxidative stress; BACE1; Autophagy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats

Keywords: ACOX1; acyl-CoA oxidase 1; AD; Alzheimer's disease; Aβ; β-amyloid peptide; AβPP; amyloid β precursor protein; BACE1; β-secretase; DBP; D-bifunctional protein; DM; diabetes mellitus; DHA; docosahexenoic acid; ELOVLs; elongase of very long chain fatt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

Keywords: JNJ-54861911; Alzheimer's disease; Amyloid β; β-secretase enzyme; BACE1; BACE inhibitors;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; ALA; α-linolenic acid; ANOVA; analyses of variance; APP; amyloid-β precursor protein; ATF4; activating transcription factor 4; BACE1; β-site APP-cleaving enzyme 1; BSA; bovine serum albumin; CAA; cerebral amy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides

Keywords: Anti-Alzheimer's disease; Ginsenosides; Molecular docking simulation; BACE1; Cholinesterase

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Determination of the protonation state for the catalytic dyad in β-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study

Keywords: Alzheimer’s disease (AD); Protonation state; Aspartatic dyad; BACE1; Hydroxyethylamine (HEA); Gromacs

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportThe flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease

Keywords: AD; Alzheimer's disease; ACSF; artificial cerebrospinal fluid; Akt; serine threonine Kinase; APP; amyloid precursor protein; Aβ; β-amyloid; BACE1; β-secretase enzyme; Bai; baicalein; fEPSP; field excitatory postsynaptic potential; GluR1; α-amino-3-h

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه