دانلود مقالات ISI درباره Bace1 + ترجمه فارسی

Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia

Keywords: AD; Alzheimer's disease; ADAM10; a-disintegrin and metalloproteinase 10; APOE; apolipoprotein E; APP; amyloid precursor protein; AQP4; aquaporin-4; Aβ; β-amyloid; BACE1; β-site amyloid precursor protein-cleaving enzyme 1; BBB; blood-brain barrier;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies

Keywords: Alzheimer’s disease; β-Secretase; BACE1; Learning and memory; Synaptic function; Mouse model

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome

Keywords: BACE1; beta-site APP-cleaving enzyme 1; BACE1-AS; beta-site APP-cleaving enzyme 1 antisense; BLAT; BLAST-like alignment tool; CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CNP; 2,3,-cyclic nucleotide 3, phosphodiesterase; COQ2; Q2 4-hydrox

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

Keywords: 4-PBA; 4-phenyl butyric acid; 6-OHDA; 6-hydroxydopamine; Aβ; amyloid beta; AD; Alzheimer's disease; ATF3; activating transcription factor 3; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; BACE1; β-site APP cleaving enz

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice

Keywords: Alzheimer's disease; Aβ; Cholesterol; Amyloid precursor protein overexpression; Mouse model; APPSL; AD; Alzheimer's disease; Aβ; amyloid beta; ACAT; Acetyl-CoA acetyltransferases; APP; amyloid precursor protein; ApoB-100; apolipoprotein B-100; ApoE; apo

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation

Keywords: PPARγ; Alzheimer's disease; RIP140; BACE1; GSK3; Aβ;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

Keywords: LRP1; low density lipoprotein receptor related-protein 1; Snx17; Sorting nexin 17; PSD95; postsynaptic density protein 95; Dab-2; disabled homolog 2; ECM; extracellular matrix; RMS; rostral migratory stream; BrdU; 5-bromo-2-deoxyuridine; CPZ; chlorpromazi

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11 month old APP/PS1 transgenic mice: A Western blot study

Keywords: AD; Alzheimer's disease; Aβ; β-Amyloid; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; GSK3β; glycogen synthase kinase-3β; BACE1; precursor protein-cleaving enzyme 1; FZS; fuzhisan; Glycogen synthase kinase-3β (GSK3β); Fuzhisan (FZS)

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds

Keywords: Alzheimer's disease; Hydroxyethylamines; GROMACS; BACE1; Flap; Population density;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease

Keywords: Alzheimer's disease; miRNA-107; BACE1; Aβ; Osthole;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease

Keywords: BACE1; Alzheimer's β-secretase; APP; Abeta peptides; Synapses; NMDA receptors; AMPA receptors; Dopamine receptors;

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2016 سفارش ترجمه

Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases

Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

Keywords: Tacrine; Alzheimer's disease; BACE1; Amyloid protein; Copper; Multi-targeted ligands; Caffeic acid;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Simple approach to the synthesis of novel tricyclic BACE1 inhibitor warhead through β-lactam opening

Keywords: Alzheimer; β-Lactam; BACE1; Tetrahydrofuran; Amidine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

Keywords: Alzheimer’s disease; Drug discovery; BACE1; Indanone; AChE

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-site amyloid precursor protein cleaving enzyme-1; Clec4g; C-type lectin-like domain containing-4g; GlcNAc; N-acetylglucosamine; GnT-III; N-acetylglucosaminyltransferase-III; Alzheimer'

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Methylation analysis of multiple genes in blood DNA of Alzheimer’s disease and healthy individuals

Keywords: DNA methylation; Alzheimer’s disease; Folate; Homocysteine; Vitamin B12; PSEN1; BACE1; MTHFR; DNMTs; APOE

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Keywords: Renin inhibitors; BACE1; Hypertension; Structure-based drug design; Enzyme inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

Keywords: AD; Alzheimer disease; FAD; familial AD; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; PDMP; dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; DMAPP; (1S,2R-d-erythro-2-N-myristoylamino)-1-phenyl-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Calcium sensing receptor mediated the excessive generation of β-amyloid peptide induced by hypoxia in vivo and in vitro

Keywords: Hypoxia; Calcium sensing receptor; Ca2+; BACE1; Aβ

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportmiR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer׳s disease

Keywords: miRNAs; microRNAs; AD; Alzheimer׳s disease; 3′ UTR; 3′-untranslated regions; NAV3; neurone navigator 3; BACE1; beta-site APP-cleaving enzyme 1; miR-29c; Alzheimer׳s disease; NAV3 protein; microRNAs; APPswe/PSΔE9 mice;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Ischemic conditions and β-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells

Keywords: CNS; central nervous system; AD; Alzheimer's disease; RBE4; rat brain endothelial cell line; OGD; oxygen and glucose deprivation; ogR; oxygen and glucose Restoration; BACE1; amyloid precursor protein (APP) β-secretase; PSEN1; presenilin-1; Aβ; amyloid p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells

Keywords: 5-Aza; 5-Aza-2′-deoxycytidine; α-CTF; α-C-terminal fragment; β-CTF; β-C-terminal fragment; AD; Alzheimer's disease; APP; amyloid precursor protein; ASBI; APP-selective BACE1 inhibitor; Aβ; β-amyloid; BACE1; β-site amyloid precursor protein-clea

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

Keywords: Flavanol; Flavonoid; Alzheimer's disease; TASTPM; BACE1; Amyloid pathology; Aβ; Dietary polyphenolic; Dementia; APP processing; Catechin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibitory effect of isoliquiritigenin isolated from Glycyrrhizae Radix on amyloid-β production in Swedish mutant amyloid precursor protein-transfected Neuro2a cells

Keywords: Glycyrrhizae Radix; Isoliquiritigenin; BACE1; β-Amyloid; Amyloidogenic pathway; APPswe-N2a;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

Keywords: Alzheimer's disease; Geniposide; APP/PS1 transgenic mice; Amyloid-β; Receptor for advanced glycation end products; AD; Alzheimer's disease; APP/PS1 mice; mPrP-APPswe/PS1dE9 AD transgenic mice; Aβ; Amyloid-beta peptide; BACE1; β-site APP cleaving enzyme

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

Keywords: Alzheimer's disease; Dendritic spines; In vivo two-photon imaging; Learning and memory; Long-term potentiation; Synaptic transmission; BACE1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice

Keywords: Amyloid-β; Alzheimer's disease; Cell differentiation; Growth factor; BACE1; Inflammation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Structural insight into the mechanism of amyloid precursor protein recognition by β-secretase 1: A molecular dynamics study

Keywords: BACE1; APP; Molecular dynamics simulation; Essential dynamics; Conformational switching; Electrostatic surface complementarity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)

Keywords: AP; action potential; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiothreitol; EGFP; enhanced green fluorescent protein; FRAP; fluorescence recovery after photobleaching; HEK293T;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

Keywords: miR; microRNA; BACE1; beta secreatase; AD; Alzheimer's disease; NAV3; neuronal navigator 3; SCA17; spinocerebellar ataxia 17; FISH; fluorescence in situ hybridization; LNA; locked nucleic acid; APP; amyloid precursor protein; PMP22; peripheral myelin prot

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity

Keywords: Sejania erecta; β-Amyloid peptide; Neuroprotection; Oxidative stress; Flavonoid; Vitexin; Aβ; amyloid β-peptide; Aβ25-35; 25-35-amino acid residue amyloid β-peptide; AD; Alzheimer's disease; ANOVA; analysis of variance; BACE1; β-site amyloid precu

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2015 سفارش ترجمه

Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BACE1; β-site APP cleaving enzyme; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FCVJ; Farne

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells

Keywords: Aβ; amyloid beta peptide; AD; Alzheimer's disease; ADAM; A disintegrin and metalloproteinase; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; beta-secretase; CHO; Chinese hamster ovary; CTF; C-terminal fragment; DN; dominant negative; FA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; Aβ (β-Amyloid) precursor protein; BACE1; β-amyloid cleavage enzyme 1; miRs; MicroRNAs; NFTs; neurofibrillary tangles; 3′UTRs; 3′-untranslated regions; UCHL1; ubiquitin carboxy-terminal hydrolase L1; miR-922; UCHL1; p

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position

Keywords: Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin

Keywords: ACh; acetylthiocholine iodide; AChE; acetylcholinesterase; AGEs; advanced glycation endproducts; AR; aldose reductase; ARI; aldose reductase inhibitor; AMT; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride; AD; Alzheimer's disease; Aβ; amyloi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; CuBD; copper binding domain; ICD; intracellular domain; PCa; prostate cancer; sAPPα; soluble APP alpha; sAPPβ; soluble APP beta; SDS-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers

Keywords: Alzheimer's disease; Amyloid beta; BACE1; Pb; Sp1; Tolfenamic acid; Aβ; amyloid β; AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid β precursor protein; BACE; beta-site APP cleaving enzyme; FBS; fetal bovine serum; Pb; lead; SEM; stan

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate

Keywords: Liquid chromatography with fluorescence detection; Immobilized enzyme reactor; BACE1; Inhibition studies; Uleine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Reprint of: Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate

Keywords: Liquid chromatography with fluorescence detection; Immobilized enzyme reactor; BACE1; Inhibition studies; Uleine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Identification, stability and expression of Sirt1 antisense long non-coding RNA

Keywords: lncRNA; long noncoding RNA; Sirt1; Sirtuin 1; NATs; natural antisense transcripts; RBPs; RNA-binding proteins; miRNAs; microRNA; HuR; human antigen R; AS; antisense transcripts; UCH1; Ubiquitin Carboxyl-Terminal Esterase L1; Ptprj; Protein Tyrosine Phosph

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice

Keywords: Stress; Corticosterone; Chronic oral dosing method; Aβ; BACE1; Mouse

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Purification of pre-miR-29 by arginine-affinity chromatography

Keywords: miRNA; microRNA; RNA; ribonucleic acid; mRNA; messenger RNA; RISC; RNA-induced silencing complex; AD; Alzheimer's disease; Aβ; β-amyloid; APP; β-amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; SPE; silica-based solid-phase extraction;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

Keywords: Bace1; neuregulin; NMDA receptor; schizophrenia; tetracycline control expression; transgenic mice

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

RanBP9 overexpression reduces dendritic arbor and spine density

Keywords: AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; BCA; Bicinchoninic acid; BDNF; Brain-derived neurotrophic factor; DRG; dorsal root ganglion; F-actin; filamentous-actin; HD; Hunt

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; Akt; protein kinase B; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; BDNF; brain-derived neurotrophic factor; CGI-S; Clinical Global Impression-Severity scale; CREB; cAMP-response element

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme-1; BCA; bicinchoninic acid; BSA; bovine serum albumin; CA; carnosic acid; CHAPS; 3-[(3-Cholamidopropyl)

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The evolution of amidine-based brain penetrant BACE1 inhibitors

Keywords: BACE; BACE1; Amyloid; Alzheimer's; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease

Keywords: Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-secretase; BSA; bovine serum albumin; CI; cell index; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; Dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic ac

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه