کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553302 | 967726 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effect of isoliquiritigenin isolated from Glycyrrhizae Radix on amyloid-β production in Swedish mutant amyloid precursor protein-transfected Neuro2a cells
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alzheimer's disease (AD) is a form of dementia, and its pathological characteristics involve the accumulation of amyloid-β (Aβ) produced by the cleavage of amyloid precursor protein (APP). According to the amyloidogenic pathway, Aβ is generated by the initial action of the β-site APP cleaving enzyme (BACE1), which forms the Aβ-containing C-terminal fragment (β-CTF) and soluble APP-β (sAPPβ). Consequently, β-CTF is cleaved by γ-secretase to yield Aβ. Therefore, the investigation of inhibitors of Aβ generation could be a strategy for AD therapy. Isoliquiritigenin inhibited BACE1 (IC50, 51.5âµM; Ki, 51.83âµM) but not BACE1 expression in Swedish mutant APP-transfected Neuro2a cells. The levels of Aβ1-40 and Aβ1-42 in the cell culture media and intracellular Aβ1-42 were reduced by 10âµM isoliquiritigenin. These effects were attributable to β-CTF and sAPPβ reduction via inhibition of cellular BACE1 activity. The data presented that isoliquiritigenin could play a role as a potent BACE1 inhibitor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 445-454
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 445-454
نویسندگان
Eun-Ju Yang, Geum-Sook Kim, Hyungjun Noh, Yu-Su Shin, Kyung-Sik Song,