دانلود مقالات ISI درباره Bace1 + ترجمه فارسی

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

Keywords: PERK; elF2α; BACE1; Amyloid-β; ATF4; CREB; Cholinergic neuron; Fear conditioning; Learning and memory; 5XFAD;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2014 سفارش ترجمه

Expression and function of APP and its metabolites outside the central nervous system

Keywords: AChRs; acetylcholine receptors; ADAM; a disintegrin and metalloprotease domain; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta; APH1; Anterior pharynx-defective 1; AICD; APP intracellular domain; BACE1; β-secretase; CNS; centr

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

BACE1 inhibitors: A head group scan on a series of amides

Keywords: BACE1; Alzheimer's disease; Inhibitors; pKa; P-gp;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line

Keywords: sIBM; sporadic inclusion body myositis; APP; amyloid precursor protein; 3MA; 3-methyladenine; CQ; chloroquine; FKBP12; FK-binding protein 12; mTORC1; mammalian target of rapamycin complex1; BACE1; β-site APP-cleaving enzyme 1; AD; Alzheimer's dementia; M

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of BACE1 inhibitors from Panax ginseng saponins-An Insilco approach

Keywords: Ginsenosides; Panax Ginseng; Alzheimer's disease; BACE1; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice

Keywords: PPARβ/δ; BACE1; RAGE; Tau; ERK1/2; Cortex;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes

Keywords: Alzheimer's disease; Fatty acids; Calcium; STAT3; BACE1; Presenilin-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Lysophosphatidic acid induces increased BACE1 expression and Aβ formation

Keywords: AD; Alzheimer's disease; NFT; neurofibrillary tangles; Aβ; β amyloid; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; oxLDL; oxidized low-density lipoprotein; CSF; cerebrospinal fluid; LPA; lysophosphatidic acid; CREB; cAMP respons

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

ReviewMolecular links between Alzheimer's disease and diabetes mellitus

Keywords: AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

SUMO1 modulates Aβ generation via BACE1 accumulation

Keywords: Alzheimer's disease; BACE1; SUMO1; Amyloid peptide;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors

Keywords: Alzheimer's disease; BACE1; C-terminus; Click chemistry; In situ screening assay; Pyrazole; EDCl; N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; HOBt; N-hydroxybenzotriazole; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; E

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

BACE1 levels are elevated in congestive heart failure

Keywords: Myocardial infarction; Congestive heart failure; BACE1; VEGF; Hypoxia; Microglia activation; Alzheimer's disease; Rat;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

Keywords: AD; Alzheimer's disease; Aβ; amyloid beta; EGCG; (−)-epigallocatechin-3-gallate; BAG2; BCL2-associated athanogene 2; LAMP1; lysosomal-associated membrane protein 1; NFTs; neurofibillary tangles; BACE1; beta-site APP cleaving enzyme-1; APP; amyloid prec

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

Keywords: LTD4; CysLT1R; NF-κB; BACE1; Aβ

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease

Keywords: Sodium azide; Hydrogen peroxide; Tau; GSK3; p35/25; BACE1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position

Keywords: Alzheimer’s disease; β-Secretase; BACE1; BACE1 inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; BACE1; β-site APP cleaving protein 1; HEK-APPSwe; HEK cells stably expressing human APP Swedish mutations; M1 mAChR; M1 muscarinic acetylcholine receptor; mAChRs; muscarinic ace

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Research reportMicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1

Keywords: AD; Alzheimer's disease; Aβ; amyloid-beta; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; sAPPβ; the secreted beta-form of APP; Aβ; amyloid-beta; BACE1; beta-site APP cleaving enzyme 1; 3′-UTR; 3′-untranslated region; sAPPβ; the se

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

MicroRNAs in Alzheimer's disease

Keywords: Alzheimer's disease; MicroRNA; Non-coding RNA; APP; BACE1; Tau;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

Keywords: Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

Keywords: Ginsenoside; Amyloid precursor protein; Amyloidgenesis; BACE1; PPARγ

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals

Keywords: Alzheimer's disease; β-Secretase; BACE1; Calcium; Calcineurin; NFAT4;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

BACE1 in Alzheimer's disease

Keywords: Aβ; β-amyloid; ACDL; acid-cluster dileucine motif; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain protein; AICD; amyloid precursor protein intracellular domain; APLP; amyloid precursor-like protein; ApoE; apolipoprotein E; APP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

Keywords: AD; Alzheimer's disease; A β 42; amyloid-β (1-42); BBB; Blood Brain Barrier; AβPP; amyloid-β protein precursor; OGD; Oxygen Glucose Deprivation; HIF-1α; Hypoxia Inducible Factor-1alpha; RBE4; rat brain capillary endothelial cells; BACE1; β-secretase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

Keywords: Alzheimer's disease; Mitochondria; C99; Amyloid precursor protein; β-Secretase; BACE1; Mitochondrial dysfunction; Oxidative DNA damage; Learning and memory; 5XFAD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression

Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ApoA-I; apolipoprotein A1; ApoE; apolipoprotein E; BACE1; β-site APP-cleaving enzyme1; CTFβ; C-terminal fragment β; HDL; high-density

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

MicroRNA networks surrounding APP and amyloid-β metabolism - Implications for Alzheimer's disease

Keywords: Alzheimer; Aβ (amyloid-β); APP (amyloid precursor protein); Animal model; BACE1; β-secretase; MicroRNA; Neurodegeneration; Splicing; Tau;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Keywords: Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-secretase/β-amyloid converting enzyme 1; Fr1; frontal cortex area 1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IDE; insulin-degrading enzyme; MCAO; middle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers

Keywords: Aβ; amyloid-β; AβPP; amyloid-β precursor protein; AD; Alzheimer disease; Aph-1; anterior pharynx defective 1; BACE1; β-site AβPP cleaving enzyme 1; Chlor; chloroquine; CHMFs; cultured human muscle fibers; Epox; epoxomicin; GSAP; γ-secretase activat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Protective effects of total alkaloidal extract from Murraya koenigii leaves on experimentally induced dementia

Keywords: Murraya koenigii; Amnesia; Memory; Alzheimer's disease; Acetylcholinesterase; BACE1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

JD-30, an active fraction extracted from Danggui-Shaoyao-San, decreases β-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; APP; amyloid protein precursor; BACE1; beta-site amyloid cleave enzyme-1; CatB; cathepsin B; DG; dentate gyrus; DSS; Danggui-Shaoyao-San; GAPDH; glyceraldehyde phosphate dehydrogenase; HFS; high frequency stim

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperNeuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor

Keywords: Alzheimer's disease; neuregulin1; ErbB4; Swedish mutation of amyloid precursor protein; amyloid beta peptide; AD; Alzheimer's disease; Aβ; amyloid beta peptide; BACE1; β-site APP-cleaving enzyme 1; DCFH-DA; 2,7-dichlorofluorescein diacetate; FAD; early-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

Keywords: Alzheimer's disease; BACE1; PKR; eIF2α; Oxidative stress; Neuroblastoma cell cultures

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

DISC1-binding proteins in neural development, signalling and schizophrenia

Keywords: DISC1; Schizophrenia; Neurodevelopment; Signalling; Synapse; Association studies; APP; Amyloid precursor protein; ATF4; Activating transcription factor 4; BACE1; β-site APP-cleaving enzyme-1; BBS4; Bardet-Biedl syndrome 4; CEP290; Centrosomal protein 2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

Keywords: Alzheimer's disease; APP; BACE1; Cholesterol; Endocytosis; NPC1;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

Keywords: Advanced glycation end products; RAGE; BACE1; Alzheimer disease; Diabetes; NF-κB pathway;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Neurodegeneration as an RNA disorder

Keywords: Neurodegeneration; Neurodegenerative disease; Non-coding RNA; Alzheimer's disease; Parkinson's disease; Huntington's disease; Trinucleotide repeat disorder; BACE1; REST; Long non-coding RNA; microRNA; HAR1; SOX2OT; mir-9; mir-132; mir-124NDDs, neurodegene

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids

Keywords: BACE1; Amyloid peptide; Substrate specificity; Unnatural amino acid

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Carbazole-containing arylcarboxamides as BACE1 inhibitors

Keywords: Alzheimer; BACE1; Carbazole; Molecular docking; Flap

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils

Keywords: Alzheimer’s disease; BACE1; Aβ fibrils; Amyloid aggregation; Quinones

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Development of a specific ELISA to measure BACE1 levels in human tissues

Keywords: BACE1; ELISA; Human; Brain; Plasma; Platelets

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; BACE; beta-APP Cleaving Enzyme; GGA; Golgi-localized γ-ear containing ADP ribosylation factor-binding protein; HC; healthy control; NC; neurological control; SD; standard deviation; TGN; trans-Golg

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

Keywords: BACE1; β-Secretase; Biosensor; Surface plasmon resonance; SPR; Enzyme; Inhibitor; Membrane reconstitution; Membrane enzyme; Alzheimer’s disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

PKC activator therapeutic for mild traumatic brain injury in mice

Keywords: ADAM, a disintegrin and metalloproteases; mTBI, mild traumatic brain injuryMild traumatic brain injury; Therapeutic; Dose dependent; Time frame; Cognitive deficits; Synaptic structures; ADAM10; BACE1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Dysregulation of SREBP2 induces BACE1 expression

Keywords: SREBP2; BACE1; Alzheimer's disease; Cholesterol synthesis; High-fat diet;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1–myricetin a case study

Keywords: BACE1; AD; Normal mode analysis; Elastic network model; MRC; Pharmacophoric feature

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease

Keywords: APP; ADAM10; BACE1; BACE2; PSEN1; PSEN2; PEN2; NCSTN; APH1B; Alzheimer's; Cerebrospinal fluid;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease

Keywords: BACE1; BDNF; LTP; α7-nAChR; Aβ; Osmotic pump

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology

Keywords: 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenals; 4-HHE; 4-hydroxyhexenal; AA; arachidonic acid; Aβ; β-amyloid; ADAM; A Disintegrin And Metalloprotease; ADAPT; Alzheimer's Disease Anti-inflammatory Prevention trial; AD; Alzheimer's disease; AE

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

Pyridinyl aminohydantoins as small molecule BACE1 inhibitors

Keywords: Alzheimer’s disease; β-Secretase; BACE1; Pyridinyl aminohydantoins

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه