کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4343966 | 1615144 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons
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کلمات کلیدی
AMPKBAG2NFTsADAM10APPLAMP1EGCGBACE1Aβ(−)-Epigallocatechin-3-gallate - (-) - Epigallocatechin-3-gallateAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استROS - ROSOkadaic acid - اسید اوکادائیکamyloid beta - بتا آمیلوئیدAlzheimer's disease - بیماری آلزایمرTau - خود راlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Lysosomal-associated membrane protein 1 - پروتئین غشای مرتبط با لیزوزوم 1amyloid precursor protein - پروتئین پیش ماده آمیلوئیPolyphenol - پلی فنلCurcumin - کورکومینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular deposits of amyloid beta (Aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Various studies suggest that the tau tangle pathology, which lies downstream to Aβ pathology, is essential to produce AD-associated clinical phenotype and thus treatments targeting tau pathology may prevent or delay disease progression effectively. In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons. Human epidemiological and animal data suggest potential positive effects of these polyphenols against AD. Here, primary rat cortical neurons treated with these polyphenols significantly up-regulated BAG2 levels at different concentrations, while only EGCG upregulated LAMP1 levels, although at higher concentrations. Importantly, curcumin doubled BAG2 levels at low micromolar concentrations that are clinically relevant. In addition, curcumin also downregulated levels of phosphorylated tau, which may be potentially attributed to the curcumin-induced upregulation in BAG2 levels in the neurons. The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 554, 25 October 2013, Pages 121-125
Journal: Neuroscience Letters - Volume 554, 25 October 2013, Pages 121-125
نویسندگان
Sachin P. Patil, Nhung Tran, Hirosha Geekiyanage, Li Liu, Christina Chan,