Keywords: Estrogen-related receptor α; APP/PS1 mice; Amyloidogenesis; Tau phosphorylation; Aβ; amyloid protein; AD; Alzheimer's disease; ADAM10; a disintegrin and metalloproteinase 10; AMPK; AMP-activated protein kinase; APP; β-amyloid precursor protein; APP/PS1
مقالات ISI (ترجمه نشده)
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Keywords: Prion; Proteolysis; Shedding; ADAM10; Neurodegeneration; Neuropathology;
Keywords: Interleukin-11; Interleukin-6; Interleukin-11 receptor; Interleukin-6 receptor; gp130; Signal transduction; Trans-signaling; Protease; ADAM17; ADAM10;
Keywords: 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: ACTH; adrenocorticotropic hormone; ADAM10; a disintegrin and metalloprotease 10; ADAR; adenosine deaminase acting on RNA; AP1/3; adaptor protein 1/3; BLOC1-3; biogenesis of lysosome-related organelles complex 1-3; DCT; dopachrome tautomerase; DSRAD; dou
Keywords: Matrix metalloproteinase; Atherosclerosis; Heart failure; Neointima formation; Abdominal aortic aneurysm; Matrix metalloproteinase inhibitors; AAA; Abdominal aortic aneurysm; ADAM10; A-disintegrin-and-metalloproteinase-domain-10; Ang I; Angiotensin I; Ang
Keywords: TMDs; ADDwR; ADDwoR; ADAM10; Immunohistochemistry
Increased ADAM10 expression in patients with immune thrombocytopenia
Keywords: Immune thrombocytopenia; ADAM10; TIMP3; FasL; LAG-3;
Alleviation of A disintegrin and metalloprotease 10 (ADAM10) on thromboangiitis obliterans involves the HMGB1/RAGE/ NF-κB pathway
Keywords: Thromboangiitis obliterans; ADAM10; HMGB1; RAGE; NF-κB;
Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing
Keywords: Amyloid-precursor protein; Neuregulin 1; Secreted APPα; Non-amyloidogenic processing; ADAM10; AD; Alzheimer's disease; APP; amyloid precursor protein; EGF; epithelial growth factor; ER; endoplasmic reticulum; NRG1; neuregulin; sAPPα; secreted APPα; s
LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer
Keywords: SNHG20; miR-140-5p; ADAM10; MEK/ERK; Cervical cancer;
NG2/CSPG4 and progranulin in the posttraumatic glial scar
Keywords: Traumatic brain injury; Glial scar; Astrocytes; Chondroitin sulfate proteoglycan; Perlecan; Progranulin; Microglia; ADAM10; Receptor protein phosphatase; Growth factor;
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers
Keywords: C. perfringens delta-toxin; Pore-forming toxin; E-cadherin; ADAM10; Transepithelial electrical resistance;
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases
Keywords: 1α,25(OH)2D3; 1,25-dihydroxyvitamin D3; ADAM10; a disintegrin and metalloproteinase 10; AIF; apoptosis-inducing factor; AP-1; activator protein 1; ATRA; all-trans retinoic acid; BMP-2; bone morphogenic protein 2; CLNX; calnexin; CRT; calreticulin; ECM; e
Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease
Keywords: AD; Alzheimer disease; Aβ; β-amyloid; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10/α-secretase (brain); APP; Amyloid Protein Precursor; APOE ε4; Apolipoprotein, allele epsilon4; BACE1; beta-site amyloid precursor protein cl
Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10
Keywords: Alzheimer's disease; Amyloid precursor protein; MTERF4; ADAM10; BACE1;
Notch as a Driver of Gastric Epithelial Cell Proliferation
Keywords: Stomach; Homeostasis; Gastric Stem Cells; Gastric Cancer; ADAM10; a disintegrin and metalloproteinase 10; GC; gastric cancer; GI; gastrointestinal; GSI; γ-secretase inhibitor; NICD; Notch receptor intracellular domain; TX; tamoxifen;
Changes in expressions of ADAM9, 10, and 17 as well as α-secretase activity in renal cell carcinoma
Keywords: α-Secretase; ADAM10; ADAM9; ADAM17; Renal cell carcinoma; Human;
The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models
Keywords: Alzheimer's disease; APP processing/regulation; Amyloid β; Iron chelation; Propargyl moiety; AChEIs; Acetyl cholinesterase inhibitors; ADAM10; a disintegrin and metalloproteinase domain 10; Aβ; amyloid β; APP; amyloid precursor protein; APOE4; apolipop
Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo
Keywords: SEP; A polysaccharide isolated from Strongylocentrotus nudus egg; TLR; toll-like receptor; NKG2D; natural-killer group 2 member D; DAP10; DNAX-associated protein 10; Akt; protein kinase B; MICA; MHC class I-related chain A; sMICA; soluble MHC class I-rela
The plasma membrane: Penultimate regulator of ADAM sheddase function
Keywords: ADAM17; ADAM10; Activation; Cell membrane asymmetry; Scramblases;
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
Keywords: AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;
Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10
Keywords: Alzheimer Disease; ADAM10; Synapse; Amyloid; Trafficking;
A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells
Keywords: Abs; absorbance; ADAM10; a disintegrin and metalloprotease domain protease 10; AG; aminoguanidine; APP; amyloid precursor protein; Aβ; amyloid β; BACE1; β site APP cleaving enzyme; CCO; cytochrome c oxidase; DDC; diethyldithiocarbamate; DMEM; Dulbecco'
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Keywords: ADAM10; Tetraspanin; APP; Presenilin;
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
Keywords: ADAM10; Notch; Intestinal stem cells; Cell lineage specification;
Association between plasma soluble RAGE and renal function is unaffected by medication usage and enzymatic antioxidants in chronic kidney disease with type 2 diabetes
Keywords: CKD; chronic kidney disease; D-CKD; diabetic CKD; ND-CKD; non-diabetic CKD; DM; diabetic patients without CKD; Non-DM; patients without diabetes and CKD; eGFR; estimated glomerular filtration rate; GPx; glutathione peroxidase; SOD; superoxide dismutase; R
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma
Keywords: MiR-140-5p; Hypopharyngeal squamous cell carcinoma(HSCC); Cell migration; Cell invasion; ADAM10; Notch1 signaling
Interferon-γ Protects from Staphylococcal Alpha Toxin-Induced Keratinocyte Death through Apolipoprotein L1
Keywords: AD; atopic dermatitis; ADAM10; a disintegrin and metalloproteinase 10; ApoL1; apolipoprotein L1; IFN; interferon; IL; interleukin; LC3; light chain 3; LDH; lactate dehydrogenase; RT-PCR; real-time PCR; SiRNA; small interfering RNA; STAT1; signal transduce
ADAM10 is essential for cranial neural crest-derived maxillofacial bone development
Keywords: ADAM10; Maxillofacial bone; Intramembranous bone formation; Cranial neural crest cells;
Molecular design and structural optimization of potent peptide hydroxamate inhibitors to selectively target human ADAM metallopeptidase domain 17
Keywords: ADAM17; ADAM10; Peptide hydroxamate; Selective inhibitor; Inflammatory bowel disease
Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
Keywords: ADAM10; 1,25-Dihydroxyvitamin D2; 25-Hydroxyvitamin D3; ERp57; L-type Ca2+ channel; TNF receptor 1
Simvastatin inhibits CD44 fragmentation in chondrocytes
Keywords: Chondrocyte; Pericellular matrix; Statin; CD44; Lipid raft; ADAM10; HA; hyaluronan; OA; osteoarthritis; OSM; Oncostatin M; BAC; bovine articular chondrocytes; HAC; human articular chondrocytes; MT1-MMP; membrane type I metalloproteinase; ICD; intracellula
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality
Keywords: CTSB; ADAM10; Non-catalytic function; LC-MS/MS; Secretome;
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
Keywords: interleukin-11; ADAM10; ADAM17; proteolysis; signal transduction
Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia
Keywords: AD; Alzheimer's disease; ADAM10; a-disintegrin and metalloproteinase 10; APOE; apolipoprotein E; APP; amyloid precursor protein; AQP4; aquaporin-4; Aβ; β-amyloid; BACE1; β-site amyloid precursor protein-cleaving enzyme 1; BBB; blood-brain barrier;
Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes
Keywords: Metalloproteinase; ADAM17; ADAM10; exosomes; shedding; inflammation;
Short communicationIncreased ADAM10 expression in preeclamptic placentas is associated with decreased expression of hydrogen sulfide production enzymes
Keywords: Hydrogen sulfide; Soluble fms-like tyrosine kinase 1; ADAM10; Placenta; Preeclampsia;
Effects of ADAM10 deletion on Notch-1 signaling pathway and neuronal maintenance in adult mouse brain
Keywords: ADAM10; A disintegrin and metalloproteinase10; APP; amyloid precursor protein; cKO; conditional knockout; dd; dideoxyribo; DG; dentate gyrus; HE; hematoxylin and eosin; Kb; kilobase(s) or 1000Â bp; kDa; kilodalton(s); LV; lateral ventricle; NICD; Notch in
Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain
Keywords: ADAM10; ADAM15; γ-Secretase; HIV-1 replication; Macrophages; CD4+ T lymphocytes; HIV-1 pre-integration complex (PIC); HIV-1 integrase;
Excessive hydrogen peroxide enhances the attachment of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts
Keywords: ADAM10; A disintegrin and metalloprotease domain protease 10; Aβ; amyloid β; APP; amyloid precursor protein; BACE1β; site APP cleaving enzyme; Ca2+; calcium ion; DDC; diethyldithiocarbamate; DMSO; dimethyl sulfoxide; DSF; disulfiram; GSH; glutathione;
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Keywords: ECs, endothelial cells; γSI, gamma-secretase inhibitor; SMCs, smooth muscle cells; NICD, Notch intracellular domain; MOI, multiplicity of infectionEndothelial cells; Inflammation; ADAM10; Notch pathway
ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice
Keywords: CBC; Intestinal Epithelium; Development; Differentiation; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10; CBCs; crypt-based columnar cells; Dll; Delta-like ligand; EGFP; enhanced green fluorescent protein; IP; intraperitoneally;
Short communicationConformational plasticity at the IgE-binding site of the B-cell receptor CD23
Keywords: IgE; immunoglobulin E; ADAM10; a disintegrin and metalloproteinase domain-containing protein 10; NOE; nuclear Overhauser effect; PDB; Protein Data Bank; Allergy; Immunoglobulin E; Antibody-receptor interactions; Immunology; X-ray crystallography;
Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample
Keywords: ADAM10; ADAM metallopeptidase 10; ADAM17; ADAM metallopeptidase 17; AREG; amphiregulin; DZ; dizygotic twin; LRT; likelihood ratio test; MZ; monozygotic twin; sFRACT; soluble fractalkine; VCA; variance component analysis;
Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons
Keywords: AD; Alzheimer's disease; Aβ; amyloid beta; EGCG; (â)-epigallocatechin-3-gallate; BAG2; BCL2-associated athanogene 2; LAMP1; lysosomal-associated membrane protein 1; NFTs; neurofibillary tangles; BACE1; beta-site APP cleaving enzyme-1; APP; amyloid prec
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex
Keywords: CADM1; ADAM10; γ-Secretase; Shedding; RIP; Tumor suppressor gene
Activation of vagus nerve by semapimod alters substance P levels and decreases breast cancer metastasis
Keywords: ADAM10; A disintegrin and metallopeptidase 10; NEP; Neprilysin; SP; Substance P; TNF; Tumor necrosis factor; Vagus; Afferent fibers; Metastasis; Substance P; CD10; Capsaicin;
Notch ligand endocytosis: Mechanistic basis of signaling activity
Keywords: ADAM; a disintegrin and metalloprotease; AFM; atomic force microscopy; CSL; CBF1, Su(H), LAG-1; Dll; Delta-like; EDTA; ethylenediaminetetraacetic acid; GSI; γ-secretase inhibitor; HD; heterodimerization domain; LNRs; Lin12/Notch repeats; NECD; Notch extr