کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022651 1580678 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers
چکیده انگلیسی
► γ-secretase components, presenilin1, Pen2, and nicastrin, are increased in s-IBM muscle. ► γ-secretase activity is increased in s-IBM muscle fibers. ► A novel γ-secretase activating protein (GSAP) is present in s-IBM muscle fibers. ► In cultured human muscle, autophagy inhibition increases γ-secretase activity. ► Experimentally inhibited autophagy leads to increase of Aβ42.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 48, Issue 1, October 2012, Pages 141-149
نویسندگان
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