BACE1 levels are elevated in congestive heart failure

► Microglia are activated in the cortex of AMI and CHF rats. ► BACE1 levels are up-regulated in the cortex and hippocampus of CHF rats. ► VEGF levels are elevated in the hippocampus of CHF rats. ► Hypoxia due to CHF might play role in the elevation of BACE1 and VEGF levels in the brain.