Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

► Focal brain ischemia time-dependently increases Aβ in ischemic brain tissues. ► PDTC attenuates brain ischemia-increased Aβ via preservation of neprilysin expression. ► PDTC also improves long-term neurological outcome after focal brain ischemia.