Keywords: پپتید β-آمیلوئید; Aβ; β-Amyloid peptide; AD; Alzheimer's disease; HO-1; heme oxygenase-1; hOBNSCs; human olfactory bulb neural stem cells; IA; incensole acetate; iPSCs; induced pluripotent stem cells; MMP; mitochondrial membrane potential; MSCs; mesenchymal stem cells;
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Keywords: پپتید β-آمیلوئید; Polymer nanoparticles; Alzheimer's disease; Antibody; Blood-brain barrier; β-Amyloid peptide;
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptide; NFTs; neurofibrillary tangles; EOAD; early-onset AD; LOAD; late-onset AD; OMOT; One-molecule-one-target; ROS; reactive oxygen species; CDMT; Combination-drugs-multi-targets; BBB; blood brain barrier; DDT;
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; β-Amyloid peptide; Electrochemical biosensor; Self-assembled monolayer; Gold nanoparticles; Monoclonal antibody;
Keywords: پپتید β-آمیلوئید; ACE; angiotensin converting enzyme; ACE2; angiotensin converting enzyme 2; aCSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; Ang-(1-7); angiotensin-(1-7); AT1R; AT1 receptor; Aβ; β-amyloid peptide; DM; diabetes mellitus; GSK-3β; glyc
Keywords: پپتید β-آمیلوئید; ACh; acetylcholine; ChEs; cholinesterases; AChE; acetylcholinesterase; EeAChE; AChE from Electrophorus electricus; hAChE; human acetylcholinesterase; BuChE; butyrylcholinesterase; eqBuChE; BChE from equine serum; ChEI; ChE inhibitor; AChEI; AChE inhibitor
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; Ferulic acid-O-alkylamines derivatives; Multifunctional agents; Butyrylcholinesterase inhibition; Aβ aggregation; Antioxidant activity; Neuroprotective effects; BuChE; butyrylcholinesterase; AChE; acetylcholinesterase; Aβ; β-amyloi
Keywords: پپتید β-آمیلوئید; 3-NPA; 3-nitropropionic acid; 6-OHDA; 6-hydroxy dopamine; AD; Alzheimer's disease; AIF; apoptosis inducing factor; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; AÃ; β-amyloid peptide; CA; trans-cinnamaldehyde; Cat; catalase; CBP;
Keywords: پپتید β-آمیلوئید; Amyloid; Protein aggregation inhibitors; Inclusion bodies; ProteoStat; Screening; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APF; aggregation propensity factor; APP; amyloid precursor protein; CR; Congo Red; DMSO; dimethyl sulfoxide; FC; flow cytom
Keywords: پپتید β-آمیلوئید; Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: پپتید β-آمیلوئید; Activities of daily living; Alzheimer's disease; β-Amyloid peptide; Motor dysfunction; Neuro-degeneration; Non-cognitive symptoms; Resting membrane potential;
Keywords: پپتید β-آمیلوئید; α-syn; α-synuclein; Aβ; β-amyloid peptide; AD; Alzheimer's disease; ALCAM; activated leukocyte cell adhesion molecule; ALS; amyotrophic lateral sclerosis; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APCs; antigen-presenting cells; BBB
Keywords: پپتید β-آمیلوئید; β-amyloid peptide; Alzheimer's disease; Biochemistry; Long-term potentiation; Operant behavior; Therapeutics;
Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; β-amyloid peptide; Cell death; Neuronal cell; Sildenafil;
PatologÃa vascular: ¿causa o efecto en la enfermedad de Alzheimer?
Keywords: پپتید β-آمیلوئید; Alzheimer; Neurodegeneración; Péptido β-amiloide; Enfermedad vascular; Flujo sanguÃneo cerebral; Barrera hematoencefálica; Alzheimer; Neurodegeneration; β-amyloid peptide; Vascular disease; Cerebral blood flow; Blood brain barrier;
The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; BACE1; β-secretase or β-site amyloid precursor protein cleaving enzyme 1; Aβ; β-amyloid peptide; APP; amyloid precursor protein; COS; chitosan oligosaccharides; MTT; 3-[4,5-dimethylthiazol-2-yl]- 2,5- diphenyltetrazolium bro
Interactions between amyloid β peptide and lipid membranes
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; β-Amyloid peptide; Fibrillation; Phospholipids; Membrane disruption; Solid-state nuclear magnetic resonance;
Interaction of the β amyloid - Aβ(25-35) - peptide with zwitterionic and negatively charged vesicles with and without cholesterol
Keywords: پپتید β-آمیلوئید; Alzheimer disease; β-amyloid peptide; Phospholipids; Cholesterol; Electron paramagnetic resonance (EPR);
Clinical benefits and pharmacology of scutellarin: A comprehensive review
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; ADE; adverse drug effect; ADR; adverse drug reaction; AIF; apoptosis-inducing factor; Akt; protein kinase B or PKB; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activat
Resveratrol ameliorates spatial learning memory impairment induced by Aβ1-42 in rats
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; ANOVA; analysis of variance; Aβ; β-amyloid peptide; BDNF; brain-derived neurotrophic factor; CREB; cAMP response binding protein; fEPSP; field excitatory postsynaptic potential; HFS; high-frequency stimulation; LTP; long-term
Effects of Huperzin-A on the Beta-amyloid accumulation in the brain and skeletal muscle cells of a rat model for Alzheimer's disease
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; β-amyloid peptide; Motor dysfunction; Electromyography; Huperzine-a; Inclusion body myositis;
NADPH oxidase contributes to streptozotocin-induced neurodegeneration
Keywords: پپتید β-آمیلوئید; 3-NT; 3-nitrotyrosine; 4-HNE; 4-hydroxy-2 nonenal; AD; Alzheimer's disease; Aβ; β-amyloid peptide; AIF; apoptosis-inducing factor; IL; interleukins; Nox; NADPH oxidase; RNS; reactive nitrogen species; ROS; reactive oxygen species; STZ; streptozotocin; W
Vitamin D3 protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis
Keywords: پپتید β-آمیلوئید; Vitamin D; Sphingosine 1-phosphate; Ceramide; ER stress; β-amyloid peptide; SH-SY5Y cells; ATF4; p38 MAPK;
Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; APP; amyloid precursor protein; ATG; autophagy-related gene; AVs; autophagic vacuoles; Aβ; β-amyloid peptide; DPA; dehydropachymic acid; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSK-3; Gl
Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; Amyloid precursor protein; BACE1; β-site amyloid precursor protein cleaving enzyme 1; BBB; Blood-brain barrier; DMF; 5,7-dimethoxyflavone; KP; Kaempferia parviflora; PMF; 3,5,7,3â²,4â²-pentametho
4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor
Keywords: پپتید β-آمیلوئید; Alzheimer's disease (AD); β-secretase (BACE1); β-amyloid peptide; Paeonia lactiflora Pall; 4-O-galloylalbiflorin; Docking; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-site amyloid precursor protein cleavin
Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats
Keywords: پپتید β-آمیلوئید; ACOX1; acyl-CoA oxidase 1; AD; Alzheimer's disease; Aβ; β-amyloid peptide; AβPP; amyloid β precursor protein; BACE1; β-secretase; DBP; D-bifunctional protein; DM; diabetes mellitus; DHA; docosahexenoic acid; ELOVLs; elongase of very long chain fatt
Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; Aβ; β-amyloid peptide; BBB; blood-brain barrier; ACh; acetylcholine; MTDL; multitarget-directed ligand; EeAChE; electric eel AChE; CAS; catalytic anionic site; PAS; p
Characterization of the interactions between β-amyloid peptide and the membranes of human SK-N-SH cells
Keywords: پپتید β-آمیلوئید; β-Amyloid peptide; Aβ-membrane interaction; Cholesterol; Alzheimer's disease;
The kynurenine pathway and neurodegenerative disease
Keywords: پپتید β-آمیلوئید; 3-HANA; 3-hydroxyanthranilic acid; 3-HAO; hydroxyanthranilate 3,4-dioxygenase; 3-HK; 3-hydroxykynurenine; α7nACh; α7-nicotinic acetylcholine; Aβ; β-amyloid peptide; ACMS; 2-amino-3-carboxymuconic 6-semialdehyde; AD; Alzheimer's disease; aSyn; α-synuc
The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity
Keywords: پپتید β-آمیلوئید; Sejania erecta; β-Amyloid peptide; Neuroprotection; Oxidative stress; Flavonoid; Vitexin; Aβ; amyloid β-peptide; Aβ25-35; 25-35-amino acid residue amyloid β-peptide; AD; Alzheimer's disease; ANOVA; analysis of variance; BACE1; β-site amyloid precu
The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; AD; Alzheimer disease; ETC; electron transport chain; DCFDA; 2,7-dichorofluorescein diacetate; mtDNA; mitochondrial DNA; APP; amyloid precursor protein; ROS; reactive oxygen species; MitoQ; mitoquinone mesylate, 10-(4,5-dimethoxy-
Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-secretase; BSA; bovine serum albumin; CI; cell index; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; Dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic ac
Neuroprotection Against Degeneration of SK-N-MC Cells Using Neuron Growth Factor-Encapsulated Liposomes with Surface Cereport and Transferrin
Keywords: پپتید β-آمیلوئید; RMP-7; transferrin; neuron growth factor; liposome; Alzheimer's disease; blood-brain barrier; β-amyloid peptide; CNS; permeability; targeted drug delivery;
The influence of inhibiting or stimulating the expression of the α3 subunit of the nicotinic receptor in SH-SY5Y cells on levels of amyloid-β peptide and β-secretase
Keywords: پپتید β-آمیلوئید; α3 Nicotinic acetylcholine receptor; β-Secretase; β-Amyloid peptide; SH-SY5Y cells;
The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin
Keywords: پپتید β-آمیلوئید; β-Amyloid peptide; Apoptosis; Inflammatory; Oxidative stress; Rats; Scutellarin;
3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ε-viniferin glucoside: Implications in Alzheimer's disease
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; β-amyloid peptide; Interaction; NMR; Polyphenol;
Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis
Keywords: پپتید β-آمیلوئید; Human endothelial cells; β-amyloid peptide; Ginsenoside Rg1; Hypoxia-induced factor-1α; Glucocorticoid receptor; ERK phosphorylation;
Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; amyloid precursor protein; SPs; senile plaques; NFTs; neurofibrillary tangles; ROS; reactive oxygen species; COSs; chitosan oligosaccharides; Aβ42; β-amyloid fragments 1-42; HFIP; 1,1,1,3,3,3-hexafl
Disease-specific expression of the serotonin-receptor 5-HT2C in natural killer cells in Alzheimer's dementia
Keywords: پپتید β-آمیلوئید; Aging; Alzheimer's disease; β-amyloid peptide; Dopamine-receptor; Leukocyte; Natural killer (NK) cell; Peripheral blood mono-nuclear cell (PBMC); Serotonin-receptor;
Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; 17β-Estradiol; Matrix metalloproteinases; β-Amyloid peptide;
Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-secretase/β-amyloid converting enzyme 1; Fr1; frontal cortex area 1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IDE; insulin-degrading enzyme; MCAO; middle
Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptide; ThT; thioflavin T; TEM; transmission electron microscope; DCFH-DA; 2â²,7â²-dichlorfluorescein-diacetate; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; ROS; reactive oxygen species; G
An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; APP; β-amyloid precursor protein; Aβ; β-amyloid peptide; EPL; external plexiform layer; FAD; familial AD; GAP43; growth-associated protein 43; GCL; granule cell layer; GL; glomerular layer; MAP2; microtubule-associated protei
Research reportModulation of ultra-low-molecular-weight heparin on [Ca2+]i in nervous cells
Keywords: پپتید β-آمیلوئید; Aβ; β-amyloid peptide; AD; Alzheimer's disease; BBB; blood-brain barrier; CaMKII; calcium/calmodulin-dependent protein kinase II; Cdk5; cyclin-dependent kinase 5; CNS; central nervous system; CSF; cerebrospinal fluid; DMEM/F12; Dulbecco's modified Eag
Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats
Keywords: پپتید β-آمیلوئید; Cell injury; Cognitive functions; Cytokines; Isoflurane; Rats; Aβ; β-amyloid peptide; AD; Alzheimer's disease; IL-1β; interleukin-1β; MAC; minimum alveolar concentrations; POCD; post-operative cognitive dysfunction; SpO2; pulse oximeter oxygen satur
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2â² region
Keywords: پپتید β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d
Behavioral PharmacologyLiquiritigenin attenuates the learning and memory deficits in an amyloid protein precursor transgenic mouse model and the underlying mechanisms
Keywords: پپتید β-آمیلوئید; Alzheimer's disease; Liquiritigenin; β-amyloid peptide; Behavior; Astrogliosis; Notch-2;
Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism
Keywords: پپتید β-آمیلوئید; Aβ; β-Amyloid peptide; AD; Alzheimer's disease; APP; Amyloid precursor protein; mt; mammillothalamic tract; NeuN; Neuronal specific nuclear protein; SAMP8; Senescence accelerated prone 8; SAMR1; Senescence accelerated resistant 1; SmTN; Submedial thalam
Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons
Keywords: پپتید β-آمیلوئید; talatisamine; channel blocker; delayed rectifier K+ channel; virtual screening; Aconitum alkaloids; AChE; acetylcholinesterase; AD; Alzheimer's disease; Aβ; β-amyloid peptide; CNPD; China Natural Products Database; EGTA; ethylene glycol-bis-(aminoethyl