کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480471 | 1551382 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The kynurenine pathway and neurodegenerative disease
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کلمات کلیدی
3-HAOACMSflavin adenine dinucleotide3-HKAβ3-hydroxykynurenine - 3-هیدروکسی ...α-synuclein - α-سینوکلینAsyn - آسین3-Hydroxyanthranilic acid - اسید 3-هیدروکسی سنترانلیلیکFAD - بدAlzheimer's disease - بیماری آلزایمرCNS - دستگاه عصبی مرکزیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیβ-amyloid peptide - پپتید β-آمیلوئیدGas - گاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals >95% of tryptophan is metabolized through the KP, ultimately leading to the production of nicotinamide adenosine dinucleotide (NAD+). A number of the pathway metabolites are neuroactive; e.g. can modulate activity of several glutamate receptors and generate/scavenge free radicals. Imbalances in absolute and relative levels of KP metabolites have been strongly associated with neurodegenerative disorders including Huntington's, Alzheimer's, and Parkinson's diseases. The KP has also been implicated in the pathogenesis of other brain disorders (e.g. schizophrenia, bipolar disorder), as well as several cancers and autoimmune disorders such as HIV. Pharmacological and genetic manipulation of the KP has been shown to ameliorate neurodegenerative phenotypes in a number of model organisms, suggesting that it could prove to be a viable target for the treatment of such diseases. Here, we provide an overview of the KP, its role in neurodegeneration and the current strategies for therapeutic targeting of the pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 40, April 2015, Pages 134-141
Journal: Seminars in Cell & Developmental Biology - Volume 40, April 2015, Pages 134-141
نویسندگان
Daniel C. Maddison, Flaviano Giorgini,