Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals

► Aβ treatment induces BACE1 expression via calcium-related signaling in astrocytes. ► NFAT4 modulates astrocytic BACE1 level via direct promoter binding. ► Aβ-elicited BACE1 expression is mediated by calcium influx. ► BACE1 is expressed in calcineurin-positive astrocytes surrounding amyloid plaques.