Keywords: Alzheimer's disease dementia; BACE1; β-secretase; Biomarker diagnosis; Mild cognitive impairment; Prediction;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: Aromatic compounds; Homalomena occulta; β-secretase;
Synthesis and biological evaluation of quinazolinone-based hydrazones with potential use in Alzheimer's disease
Keywords: Quinazolinone; BACE1; Alzheimer's disease; Schiff base; Hydrazone; β-Secretase;
Keywords: AC; adenylyl cyclase; AKAP; A kinase anchoring protein; BACE; β-secretase; C1; AC catalytic domain 1; C2; AC catalytic domain 2; CaM; calmodulin; GPCR; G protein-coupled receptor; PDE; phosphodiesterase; PKA; protein kinase A; PKC; protein kinase C; PP2A
Keywords: Multi-target drug design; Steered molecular dynamics; Alzheimer's disease; Amyloid beta peptide; β-secretase; PPARγ; LXRα;
Keywords: Lipid rafts; Docosahexaenoic acid; Cholesterol; Plasmalogens; β-secretase; Amyloid precursor protein; Amyloidogenic processing; Human brain cortex; Lewy body diseases; Alzheimer's disease; Parkinson's disease;
Keywords: AChE; acetylcholinesterase; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; APP; amyloid precursor protein; ANOVA; analysis of variance; BACE; β-secretase; CAT; catalase; CSF; cerebral spinal fluid; DTNB; 5,5â²-Dithiobis(2-nitrobenzoi
Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation
Keywords: Alzheimer's disease (AD); BACE inhibitor; β-Secretase; Oxazine; Structure-based design;
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand
Keywords: β-secretase; Alzheimer's disease; Memapsin 2; BACE-1; Isoxazoline;
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors
Keywords: Multi-target-directed ligands; Acetylcholinesterase; β-Secretase; Donepezil; Hybridization;
Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer's disease via activation of Nrf2/ARE pathway and inhibition of β-secretase
Keywords: Plumbagin; GFAP; Astrocytes; Trigonelline; β-secretase; Alzheimer's disease;
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease
Keywords: Alzheimer; Amyloid-β; β-Secretase; γ-Secretase; Prevention; Therapy;
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors
Keywords: Alzheimer's disease; Amyloid precursor protein; Chloroquine; Lysosome; Autophagy; β-secretase; BACE-1; Indirect inhibitor; Phenotypic;
A capillary electrophoresis-mass spectrometry based method for the screening of β-secretase inhibitors as potential Alzheimer's disease therapeutics
Keywords: Alzheimer's disease; β-secretase; Kinetics; Inhibition; Capillary electrophoresis; Mass spectrometry detection;
Development and comprehensive comparison of two on-line capillary electrophoretic methods for β-secretase inhibitor screening
Keywords: Alzheimer's disease; β-secretase; Capillary electrophoresis; Electrophoretically mediated microanalysis; Inhibition; Kinetics; Transverse diffusion of laminar flow profiles; Validation;
Research ArticlePharmacophore based 3D-QSAR modeling, virtual screening and docking for identification of potential inhibitors of β-secretase
Keywords: BACE1; β-secretase; AD; Alzheimer's disease; Aβ; amyloid-β; BBB; blood brain barrier; PDB; protein data bank; rmsd; root mean square deviation; IC50; inhibitory concentration; β-secretase; Alzheimer's disease; Pharmacophore; Virtual screening; Doc
Multi-structure docking analysis of BACE1 crystal structures and non-peptidic ligands
Keywords: Multi-structure docking; BACE1; β-Secretase; Non-peptidic inhibitors; Chemometrics methods;
Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors
Keywords: Alzheimer's disease; BACE1 inhibitor; β-Secretase; Drug discovery; Cyclic acylguanidine;
Expression of Alzheimer's disease risk genes in ischemic brain degeneration
Keywords: Alzheimer's disease; Brain ischemia; β-secretase; Presenilin 1 and 2; Apoptosis;
Computational insights into the protonation states of catalytic dyad in BACE1-acyl guanidine based inhibitor complex
Keywords: BACE-1; β-secretase; Molecular dynamics; DFT; Protonation state; Docking;
Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats
Keywords: ACOX1; acyl-CoA oxidase 1; AD; Alzheimer's disease; Aβ; β-amyloid peptide; AβPP; amyloid β precursor protein; BACE1; β-secretase; DBP; D-bifunctional protein; DM; diabetes mellitus; DHA; docosahexenoic acid; ELOVLs; elongase of very long chain fatt
A signal-on electrochemical strategy for protease detection based on the formation of ATCUN-Cu(II)
Keywords: Electrochemical sensors; Protease; ATCUN motif; Copper; β-secretase;
Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein
Keywords: Cinnamomum cassia; β-Amyloid; Alzheimer disease; β-Secretase; Medioresinol; Cryptamygin A; Aβ40; β-amyloid(1-40); ACN; acetonitrile; AD; Alzheimer disease; APP; amyloid precursor protein; BuOH; butanol; CHO; Chinese hamster ovary; DMSO; dimethyl sulfo
The binding of small carbazole derivative (P7C3) to protofibrils of the Alzheimer's disease and β-secretase: Molecular dynamics simulation studies
Keywords: Alzheimer's disease; Amyloid β aggregates; β-Secretase; Molecular dynamics simulations; P7C3;
The Streptomyces metabolite anhydroexfoliamycin ameliorates hallmarks of Alzheimer's disease in vitro and in vivo
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; ARE; antioxidant response element; Aβ; amyloid-beta; BACE; β-secretase; EDTA; ethylenediaminetetraacetic acid; ERK; Extracellular signal-regulated kinase; GSK3β; glycogen synthase kinase-3beta;
Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model
Keywords: AD; Alzheimer׳s disease; Aβ; amyloid β; AChE; acetylcholinesterase; ANOVA; analysis of variance; ANSM; Agence Nationale de Sécurité des Médicaments (French); APP; amyloid precursor protein; b-APP; b-amyloid precursor protein; ATCI; acetylthiocholine
Isolation of cholinesterase and β-secretase 1 inhibiting compounds from Lycopodiella cernua
Keywords: Lycopodiella cernua; Serratene-type triterpenoids; Hydroxy unsaturated fatty acid; Cholinesterase; β-Secretase;
Discovery of potent iminoheterocycle BACE1 inhibitors
Keywords: Alzheimer's disease; β-Secretase; BACE; Aspartyl protease inhibitors; Structure-based drug design;
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position
Keywords: Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;
Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions
Keywords: Lipid rafts; Membrane lipids; Polyunsaturated fatty acids; Docosahexaenoic acid; Membrane viscosity; Anisotropy; β-secretase; Amyloid precursor protein; Alzheimer's disease; Frontal cortex; Entorhinal cortex;
Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease
Keywords: Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-secretase; BSA; bovine serum albumin; CI; cell index; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; Dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic ac
Expression and function of APP and its metabolites outside the central nervous system
Keywords: AChRs; acetylcholine receptors; ADAM; a disintegrin and metalloprotease domain; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta; APH1; Anterior pharynx-defective 1; AICD; APP intracellular domain; BACE1; β-secretase; CNS; centr
The influence of inhibiting or stimulating the expression of the α3 subunit of the nicotinic receptor in SH-SY5Y cells on levels of amyloid-β peptide and β-secretase
Keywords: α3 Nicotinic acetylcholine receptor; β-Secretase; β-Amyloid peptide; SH-SY5Y cells;
Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies
Keywords: BACE-1; Benzodiazepines; Alzheimer's disease; Memapsin 2; β-Secretase;
Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors
Keywords: β-Secretase; Hydroxyethylamine; SPR; Kinetics; Thermodynamics; Residence time;
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Keywords: Alzheimer's disease; BACE; Aminooxazolines; β-Secretase; Oxazolines;
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity
Keywords: Conformational constraint; Alzheimer's disease; BACE1 inhibitor; Macrocycle; β-Secretase;
Featured Articleβ-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
Keywords: Alzheimer's disease; Dementia; Biomarker; Amyloid cascade; β-secretase;
Novel BACE1 inhibitors with a non-acidic heterocycle at the P1â² position
Keywords: Non-acidic inhibitor; β-Secretase; Alzheimer's disease; Quantitative structure-activity relationship; Hydroxymethylcarbonyl isostere;
Lysophosphatidic acid induces increased BACE1 expression and Aβ formation
Keywords: AD; Alzheimer's disease; NFT; neurofibrillary tangles; Aβ; β amyloid; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; oxLDL; oxidized low-density lipoprotein; CSF; cerebrospinal fluid; LPA; lysophosphatidic acid; CREB; cAMP respons
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Keywords: Coumarin; Furanocoumarin; Pyranocoumarin; β-Secretase; Structure-activity relationships;
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Keywords: Alzheimer's disease (AD); β-Secretase; BACE-1 inhibitors; Aminoimidazoles; Efflux; In vivo brain efficacy;
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors
Keywords: β-Secretase; Alzheimer's disease; Memapsin 2; Inhibitor; Design and synthesis; Dihydroquinazoline;
Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design
Keywords: Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
Keywords: Aβ amyloid; Alzheimer's disease; β-Secretase; BACE-1 inhibition; Hydroxylamine (HEA) isostere;
Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals
Keywords: Alzheimer's disease; β-Secretase; BACE1; Calcium; Calcineurin; NFAT4;
Expression analysis of human β-secretase in transgenic tomato fruits
Keywords: Alzheimer's vaccine; β-Secretase; Recombinant protein; Lycopersicon esculentum; Transgenic plant;
MicroRNA networks surrounding APP and amyloid-β metabolism - Implications for Alzheimer's disease
Keywords: Alzheimer; Aβ (amyloid-β); APP (amyloid precursor protein); Animal model; BACE1; β-secretase; MicroRNA; Neurodegeneration; Splicing; Tau;
Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
Keywords: Alzheimer's disease; Mitochondria; C99; Amyloid precursor protein; β-Secretase; BACE1; Mitochondrial dysfunction; Oxidative DNA damage; Learning and memory; 5XFAD;
Secretases as therapeutic targets for Alzheimer's disease
Keywords: Alzheimer's disease; γ-Secretase; β-Secretase; Aβ;