دانلود مقالات ISI درباره Β-Secretase + ترجمه فارسی

Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

Keywords: α-CTF; α-cleaved carboxyterminal fragment of APP (also known as C83); Aβ; amyloid-β peptide; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BACE; β-secretase; BBG; brilliant blue G; BzATP; 2′(3â€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APP; amyloid-precursor protein; CTF; C-terminal fragment of APP; sAPP; soluble APP; BACE; beta-site of APP cleaving enzyme; DHA; docosahezaenoic acid; PUFA; polyunsaturated fatty acid; ELISA; enzyme linked imm

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors

Keywords: Alzheimer's disease; β-Secretase; Pentapeptides; Bioisosteres; Phenylcycloalkylamines;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Alzheimer's secretases regulate voltage-gated sodium channels

Keywords: Alzheimer's disease; BACE1; β-Secretase; Presenilin; γ-Secretase; Voltage-gated sodium channel; Sodium channel β2-subnit;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Evidence for dimeric BACE-mediated APP processing

Keywords: Alzheimer's disease; Aspartyl protease; β-Secretase; Endosome;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

Keywords: β-Secretase; Alzheimer's disease; Oxidative stress; γ-Secretase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput

Keywords: BACE; β-secretase; DBA; direct binding assay; DSC; differential scanning calorimetry; ED; equilibrium dialysis; EDC; N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide; ESI; electrospray ionization; FAC; frontal affinity chromatography; HTS; high-throughpu

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of β-secretase (BACE1)

Keywords: BACE1; Alzheimer's disease; β-Secretase; Macrocyclic; Serum stability; Phosphino dipeptide isostere;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

β-Secretase as a Therapeutic Target for Alzheimer's Disease

Keywords: β-secretase; amyloid precursor protein secretase; inhibitor drug; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Aspartic protease inhibitors via C1-homologation of peptidic aldehydes and studies on reduced amide isosteres

Keywords: β-Secretase; Transition state isostere; Hydroxyethylamine; Reduced amide; Grignard reagent; Indole synthesis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

A PNA-DNA hybridization chip approach for the detection of β-secretase activity

Keywords: PNA-DNA hybridization; Addressable chip; β-Secretase; On-chip assay; Immunoassay;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Pathogenic mechanisms in Alzheimer's disease

Keywords: Amyloid precursor protein; β-Secretase; γ-Secretase; Amyloidogenic processing;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

The regulation of β-secretase by cholesterol and statins in Alzheimer's disease

Keywords: Cholesterol; Statin; β-Amyloid; β-Secretase; Targeting; Alzheimer's; Rafts;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Design and synthesis of highly active Alzheimer's β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

Keywords: Alzheimer's disease; BACE1 inhibitor; β-Secretase; Bioisostere;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Novel α-secretase cleavage of Alzheimer's amyloid β precursor protein in the endoplasmic reticulum of COS7 cells

Keywords: Alzheimer's disease; Amyloid precursor protein; α-Secretase; β-Secretase; Endoplasmic reticulum; Brefeldin A;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Expression and characterization of recombinant β-secretase from Trichoplusia ni BTI Tn5B1-4 cells transformed with cDNAs encoding human β1,4-galactosyltransferase and Gal β1,4-GlcNAc α 2,6-sialytransferase

Keywords: Trichoplusia ni BTI Tn5B1-4 cells; β-Secretase; Activity; Purification; Human β1,4-galactosyltransferase; Gal β1,4-GlcNAc α 2,6-sialytransferase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Extracellular release of BACE1 holoproteins from human neuronal cells

Keywords: Alzheimer's disease; BACE1; β-Secretase; Metalloprotease; Shedding;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice

Keywords: β-Secretase; Alternative splice variants; Brain regions; Age dependent; APP; β-Amyloid; tg2576 transgenic mice; Alzheimer disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase

Keywords: β-Secretase; Docking; 3D-QSAR; CoMFA; CoMSIA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه