کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2536929 1559171 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathogenic mechanisms in Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Pathogenic mechanisms in Alzheimer's disease
چکیده انگلیسی
Alzheimer's disease is a progressive neurodegenerative disorder associated with aging and characterized by neurofibrillary tangles and amyloid plaques that deposit in the brain, triggering the neurodegenerative phenomena and leading to neuronal death. Amyloid plaques are primarily composed of β-amyloid peptides, which derive from the Amyloid Precursor Protein (APP) upon the consequential action of β- and γ-secretase. This review discusses recent literature on β- and γ-secretase, and on those cellular factors, like cholesterol and phosphorylation of APP, that are involved in aging and may affect the function of both β- and γ-secretase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 545, Issue 1, 1 September 2006, Pages 29-38
نویسندگان
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