Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates

Six HEA core BACE-1 inhibitors with variations on the prime side alkyl substituted 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates were synthesized and evaluated for their BACE-1 in vitro and in vivo inhibitory activities.