Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; Antimicrobial peptides; Antimicrobial activity; Membrane permeabilization; Bacterial killing kineticsAMPs, antimicrobial peptides; MPER, membrane-proximal external region; HIV-1, human immunodeficiency virus type 1; LPS, lipopolysaccharides; CFU, colony-f
مقالات ISI HIV-1، ویروس نقص ایمنی بدن نوع 1 (ترجمه نشده)
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Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, Human immunodeficiency virus type 1; RT-LAMP, reverse transcription-loop-mediated isothermal amplification; CV, coefficient of variation; HIV-2, Human immunodeficiency virus type 2; HTLV-1, Human T lymphotrophic virus type 1; HCV, Hepatitis C virus
Influence of glutathione availability on cell damage induced by human immunodeficiency virus type 1 viral protein R
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; CFU, colony forming unit; COX, cytochrome c oxidase; DHA, dehydroascorbic acid; ETC, electron transport chain; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GSH, glutathione; GSSG, glutathione disulfide; HIV-1, human immunodeficiency virus type 1; NAC,
DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; RBP, RNA-binding protein; RHA, RNA helicase A/DHX9; gRNA, genomic RNA; dsRBDs, dsRNA-binding domainsx; 5′-UTR, 5′-untranslated region; gRNP, genomic ribonucleoprotein particles; NC, nucleocapsid; CES, core encap
Evolution under Drug Pressure Remodels the Folding Free-Energy Landscape of Mature HIV-1 Protease
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; PIs, clinical protease inhibitors; DRMs, drug resistance mutations; PR, optimized wild-type HIV-1 protease; PR20, extremely drug-resistant variant of PR bearing 19 mutations; DSC, differential scanning calorimet
Molecular Mechanism of HIV-1 Vpr for Binding to Importin-α
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; Vpr, viral protein R; HIV-1, human immunodeficiency virus type 1; NLS, nuclear localization signal; h-importin-α1, human importin-α1; IBB, importin-β-binding; ARM, armadillo; GST, glutathione S-transferase; ITC, isothermal titration calorimetry; DLS, dyna
Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; ADAM, alkenyldiarylmethane; NNRTI, non-nucleoside reverse transcriptase inhibitor; RT, reverse transcriptase; HIV-1, human immunodeficiency virus type 1; AIDS, acquired immune deficiency syndrome; ART, antiretroviral therapy; NRTI, nucleoside reverse tran
During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, Human Immunodeficiency Virus type 1; HIV-1 VL, HIV-1 viral load; ART, Anti-retroviral therapy; HIC, HIV-1 controllers; NNRTI, Non-nucleoside reverse-transcriptase inhibitors; NRTI, nucleoside/nucleotide reverse transcriptase inhibitors; VLS, Viral
The ABCA1 domain responsible for interaction with HIV-1 Nef is conformational and not linear
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; ABCA1, ATP-binding cassette transporter A1; HIV-1, human immunodeficiency virus type 1; Nef, negative factor; HDL, high density lipoprotein; HEK, human embryonic kidney cells; Hcf1, host cell factor 1ABCA1; HIV-1; Nef; Interaction; Yeast 2-hybrid; Co-immu
Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; MMLV, Moloney murine leukemia virus; RNase H, ribonuclease H; RT, reverse transcriptase; PAGE, polyacrylamide gel electrophoresisMoloney murine leukemia virus; Reverse transcriptase; RNase H activity; Template–p
A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; RT, reverse transcriptase; NNRTI, non-nucleoside reverse transcriptase inhibitor; DAPY, diarylpyrimidine; DATA, diaryltriazine; NNIBP, non-nucleoside inhibitor binding pocket; PDB, protein data bankHIV-1; Revers
Site-Specific Structural Variations Accompanying Tubular Assembly of the HIV-1 Capsid Protein
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; NTD, N-terminal domain; CTD, C-terminal domain; cryoEM, cryoelectron microscopy; 2D, two-dimensional; 3D, three-dimensional; MAS, magic-angle spinning; PEG-8000, polyethylene glycol 8000; TEM, transmission elect
Dissecting the Molecular Mechanism of IVIg Therapy: The Interaction between Serum IgG and DC-SIGN is Independent of Antibody Glycoform or Fc Domain
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; B4GALT1, β-1,4-galactosyltransferase; CRD, carbohydrate recognition domain; FcγR, Fcγ receptors; HIV-1, human immunodeficiency virus type 1; IgG, immunoglobulin G; ITP, immune thrombocytopenia; IVIg, intravenous immunoglobulin; sFc, α2,6-sialylated Fc; TO
Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; TM, transmembrane; GPI, glycosylphosphatidylinositol; delGPI, GPI deleted; AGM, African green monkey; mab, monoclonal antibody; AME, Amphotericin B methyl esterHIV-1; Tetherin; Vpu; Overexpression
HIV-1 p6 — a structured to flexible multifunctional membrane-interacting protein
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; ALIX, ALG-2 interacting protein 1/X; DPC, Dodecylphosphatidylcholine; HIV-1, human immunodeficiency virus type 1; L-domains, late assembly domains; NMR, nuclear magnetic resonance; NOESY, Nuclear Overhauser Effect Spectroscopy; SPR, surface plasmon resona
Emerging Role of the Host Restriction Factor Tetherin in Viral Immune Sensing
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; IFN, interferon; HIV-1, human immunodeficiency virus type 1; SAMHD1, sterile alpha motif and histidine/aspartic acid domain-containing protein 1; DC, dendritic cell; SIV, simian immunodeficiency virus; PRR, pattern-recognition receptor; GPI, glycosyl-phos
Dispersed Sites of HIV Vif-Dependent Polyubiquitination in the DNA Deaminase APOBEC3F
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; A3F, APOBEC3F; A3G, APOBEC3G; HIV-1, human immunodeficiency virus type 1; Vif, virion infectivity factor; Ub, ubiquitin; polyUB, polyubiquitination; FBS, fetal bovine serum; PBS, phosphate-buffered salineAPOBEC3F; APOBEC3G; HIV; Vif; ubiquitin
SAMHD1 Host Restriction Factor: A Link with Innate Immune Sensing of Retrovirus Infection
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; MDM, monocyte-derived macrophage; pDC, plasmacytoid dendritic cell; RTI, reverse-transcribed intermediate; AGS, Aicardi–Goutières syndrome; HIV-1, human immunodeficiency virus type 1; HTLV-1, human T cell leukemia virus type 1; CDK1, cyclin-dependent kina
Mirror image phage display – Generating stable therapeutically and diagnostically active peptides with biotechnological means
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; AD, Alzheimer's disease; Aβ, amyloid-β; Dag, hepatitis delta antigen; HDV, hepatitis delta virus; HIV-1, human immunodeficiency virus type 1; NMR, nuclear magnetic resonance; SH3, Src homology 3; ThT, thioflavineMirror image phage display; d-enantiomeric
Aspects of HIV-1 assembly that promote primer tRNALys3 annealing to viral RNA
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; MA, matrix protein; CA, capsid protein; NC, nucleocapsid protein; PR, protease; RT or, reverse transcriptase; IN, integrase; PBS, primer binding site; MuLV, murine leukemia virus; AMV, avian myeloblastosis virus
Dietary Intervention Prevents Dyslipidemia Associated With Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1–Infected Individuals : A Randomized Trial
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; AIDS; cholesterol; nutrition24 h-DR, 24-h dietary recall; AIDS, acquired immune deficiency syndrome; BMI, body mass index; HAART, highly active antiretroviral therapy; HDL-C, high-density lipoprotein-cholesterol; HIV-1, human immunodeficiency virus type 1
A gene delivery system for insect cells mediated by arginine-rich cell-penetrating peptides
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; CecB, cecropin B; CPP, cell-penetrating peptide; Cy3, Cyanine 3; EGFP, enhanced green fluorescent protein; GFP, green fluorescent protein; HIV-1, human immunodeficiency virus type 1; HR9, histidine-rich nona-arginine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5
Understanding the molecular mechanism of sequence dependent Tenofovir removal by HIV-1 reverse transcriptase: Differences in primer binding site versus polypurine tract
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; WT RT, wild type reverse transcriptase; N[t]RTI, nucleoside [nucleotide] reverse transcriptase inhibitor; TFV, tenofovir; NNRTI, nonnucleoside reverse transcriptase inhibitor; EFV, efavirenz; PPT, polypurine tra
The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; SIV, Simian immunodeficiency virus; RSV, Rous sarcoma virus; MuLV, murine leukemia virus; Vif, virion infectivity factor; APOBEC3G, apolipoprotein B mRNA-editing enzyme-catalytic, polypeptide-like 3G; SOCS, supp
Solution Structure of the HIV-1 Exon Splicing Silencer 3
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; ESS3, exon splicing silencer 3; 3D, three-dimensional; SRE, splicing regulatory element; ESE, exonic splicing enhancer; ISS, intronic splicing silencer; hnRNP, heterogeneous nuclear ribonucleoprotein; RRE, Rev-r
Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; ART, antiretroviral therapy; AS-PCR, allele-specific real-time PCR; RTV, ritonavir; PI, protease inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitorHIV-1; ART; Drug resistance; Minority drug-resista
Reverse transcriptase mutation K65N confers a decreased replication capacity to HIV-1 in comparison to K65R due to a decreased RT processivity
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, Human immunodeficiency virus type 1; RT, Reverse transcriptase; TFV, tenofovir; TDF, tenofovir disoproxil fumarate; ddI, didanosineReplication; Attenuation; RT mutation; K65R, Lys65Arg; K65N, Lys65Asn
Role of lipid rafts in innate immunity and phagocytosis of polystyrene latex microspheres
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; BCG-CWS, Bacillus Calmette-Guérin cell-wall skeleton; CXCL10, chemokine (C-X-C motif) ligand 10; FBS, fetal bovine serum; F-PSL MS, fluorescent-polystyrene latex microspheres; HIV-1, human immunodeficiency virus type 1; HPTLC, high-performance thin-layer
The Role of Cellular Factors in Promoting HIV Budding
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; NC, nucleocapsid protein; EIAV, equine infectious anemia virus; MVB, multivesicular body; PRD, proline-rich C-terminal domain; ESCRT, endosomal sorting complex required for transport; CHMP, charged multivesicula
Functional Characterization of Human Cyclin T1 N-Terminal Region for Human Immunodeficiency Virus-1 Tat Transcriptional Activation
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; P-TEFb, positive transcription elongation factor b; CycT1, cyclin T1; CDK9, cyclin-dependent kinase 9; TAR, transactivation response element; aa, amino acids; TRM, Tat–TAR recognition motif; LTR, long terminal r
The Molecular Architecture of HIV
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; VLP, virus-like particle; MA, matrix; CA, capsid; NC, nucleocapsid; RNP, ribonucleoprotein; ESCRT, endosomal sorting complex required for transport; PR, proteasehuman immunodeficiency virus; assembly; maturation
Mechanistic insights into the roles of three linked single-stranded template binding residues of MMLV reverse transcriptase in misincorporation and mispair extension fidelity of DNA synthesis
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; MMLV, Moloney murine leukemia virus; RT, reverse transcriptase; HIV-1, human immunodeficiency virus type 1; WT, wide typeFidelity; HIV-1; Kinetics; Moloney murine leukemia virus; Reverse transcriptase; Structure–function
Sprouty2 Regulates PI(4,5)P2/Ca2+ Signaling and HIV-1 Gag Release
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; MA, matrix; L, late; PI(4,5)P2, phospholipid phosphatidylinositol 4,5-bisphosphate; ESCRT, endosomal sorting complex required for transport; IP3R, inositol (1,4,5)-triphosphate receptor; RTK, receptor tyrosine k
HIV-1 Infection Induces Acetylation of NPM1 That Facilitates Tat Localization and Enhances Viral Transactivation
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; NPM1, nucleophosmin; LTR, long terminal repeat; HAT, histone acetyltransferase; siRNA, small interfering RNA; ChIP, chromatin immunoprecipitation; PBS, phosphate-buffered saline; EDTA, ethylenediaminetetraacetic
The Reverse Transcriptase Encoded by the Non-LTR Retrotransposon R2 Is as Error-Prone as That Encoded by HIV-1
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; RT, reverse transcriptase; LTR, long terminal repeat; HIV-1, human immunodeficiency virus type 1; MuLV, murine leukemia virus; AMV, avian myeloblastosis virus; TPRT, target-primed reverse transcription; T/P, template/primerreverse transcriptases; retrotra
2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; 2-Hydroxyisoquinoline-1,3(2H,4H)-dione; Integrase; Ribonuclease H; Magnesium complexation; AntiretroviralHAART, highly active antiretroviral therapies; HIV-1, human immunodeficiency virus type 1; IN, integrase; LDA, lithium diisopropylamide; LEDGF, lens e
ESCRT Machinery Potentiates HIV-1 Utilization of the PI(4,5)P2-PLC-IP3R-Ca2+ Signaling Cascade
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; IP3R, inositol 1,4,5-triphosphate receptor; PLC, phospholipase C; IP3, inositol (1,4,5)-triphosphate; VLP, virus-like particle; ER, endoplasmic reticulum; DAG, diacylglycerol; PI(4,5)P2, phosphatidylinositol-(4,
Multifaceted Counter-APOBEC3G Mechanisms Employed by HIV-1 Vif
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; deaminase; peptides; enzyme kinetics; virion; innate immunityss, single stranded; wt, wild type; PBS, phosphate-buffered saline; Ni–NTA, nickel–nitrilotriacetic acid; OD, optical density; HIV-1, human immunodeficiency virus type 1; PIC, pre-integration co
Beyond Plasma Membrane Targeting: Role of the MA domain of Gag in Retroviral Genome Encapsidation
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; gRNA, genomic RNA; MA, matrix; CA, capsid; NC, nucleocapsid; HIV-1, human immunodeficiency virus type 1; RSV, Rous sarcoma virus; BLV, bovine leukemia virus; HTLV-I, human T cell lymphotropic/leukemia virus type 1; NLS, nuclear localizations signals; NES,
Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV, human immunodeficiency virus; HIV-1, human immunodeficiency virus type 1; GNP, gold glyconanoparticle; mAb, monoclonal antibody; SPR, surface plasmon resonance; STD, saturation transfer difference; GlcC5S, 5-(thio)pentyl β-d-glucopyranoside; RU, resp
Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; MA, matrix; HBR, highly basic region; PI(4,5)P2, phosphatidylinositol-(4,5)-bisphosphate; CA, capsid; NC, nucleocapsid; PM, plasma membrane; WT, wild type; IP6, inositol hexakisphosphate; PS, phosphatidylserine;
RNA Interference as a Tool for Exploring HIV-1 Robustness
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; siRNA, short interfering RNA; HIV-1, human immunodeficiency virus type 1; RNAi, RNA interference; shRNA, short hairpin RNA; FBS, fetal bovine serumRNAi; HIV-1; escape; evolution
Structure and Stoichiometry of Template-Directed Recombinant HIV-1 Gag Particles
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; MA, matrix; CA, capsid; NC, nucleocapsid; VLP, virus-like particle; TEM, transmission electron microscopy; PEG, polyethylene glycol; ss, single-stranded; DLS, dynamic light scattering; EM, electron microscopy; 3
HIV-1 Matrix Protein Binding to RNA
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; human immunodeficiency virus type 1; Gag; matrix; phosphatidylinositol-(4,5)-bisphosphate; nuclear magnetic resonanceMA, matrix; HIV-1, human immunodeficiency virus type 1; PrGag, precursor Gag; PI(4,5)P2, phosphatidylinositol-(4,5)-bisphosphate; PM, plas
Identification of Critical Motifs within HIV-1 Integrase Required for Importin α3 Interaction and Viral cDNA Nuclear Import
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; PIC, pre-integration complex; Vpr, viral protein R; MA, matrix; IN, integrase; CCD, catalytic core domain; CTD, C-terminal domain; NLS, nuclear localization signal; LTR, long terminal repeat; Co-IP, co-immunopre
Flexible Nature and Specific Functions of the HIV-1 Nucleocapsid Protein
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; ERV, endogenous retrovirus; gRNA, genomic RNA; HAART, highly active antiretroviral therapy; HIV-1, human immunodeficiency virus type 1; LTR, long terminal repeat; MA, matrix; NA, nucleic acid; NC, nucleocapsid; PBS, primer binding site; PDB, Protein Data
Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; HIV-1, human immunodeficiency virus type 1; Env, envelope; CDR, complementarity-determining region; MPER, membrane-proximal external region; WT, wild type; IL, interleukin; mAb, monoclonal antibody; bNAb, broadly neutralizing antibody; PDB, Protein Data B
Design of in Vitro Symmetric Complexes and Analysis by Hybrid Methods Reveal Mechanisms of HIV Capsid Assembly
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; CACTD, C-terminal domain of CA; CANTD, N-terminal domain of CA; cryoEM, electron cryomicroscopy; HIV-1, human immunodeficiency virus type 1; HTLV, human T-cell leukemia virus; MLV, murine leukemia virus; MPMV, Mason-Pfizer monkey virus; RSV, Rous sarcoma
In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; IN, integrase; NLS, nuclear localization signal; LTR, long terminal repeat; PIC, preintegration complex; IBD, integrase binding domain; HIV-1, human immunodeficiency virus type 1; 1O2, singlet oxygen; CR1, charged region 1; MBP, maltose binding protein; F
The Conformation and Orientation of a 27-Residue CCR5 Peptide in a Ternary Complex with HIV-1 gp120 and a CD4-Mimic Peptide
Keywords: HIV-1، ویروس نقص ایمنی بدن نوع 1; CCR5, CC chemokine receptor 5; CXCR4, CXC chemokine receptor 4; Fmoc, fluorenylmethyloxycarbonyl; HIV-1, human immunodeficiency virus type 1; HOHAHA, homonuclear–Hartmann–Hahn; NOESY, nuclear Overhauser enhancement spectroscopy; NOE, nuclear Overhauser en