کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2185105 | 1095960 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The Role of Cellular Factors in Promoting HIV Budding The Role of Cellular Factors in Promoting HIV Budding](/preview/png/2185105.png)
Human immunodeficiency virus type 1 (HIV-1) becomes enveloped while budding through the plasma membrane, and the release of nascent virions requires a membrane fission event that separates the viral envelope from the cell surface. To facilitate this crucial step in its life cycle, HIV-1 exploits a complex cellular membrane remodeling and fission machinery known as the endosomal sorting complex required for transport (ESCRT) pathway. HIV-1 Gag directly interacts with early-acting components of this pathway, which ultimately triggers the assembly of the ESCRT-III membrane fission complex at viral budding sites. Surprisingly, HIV-1 requires only a subset of ESCRT-III components, indicating that the membrane fission reaction that occurs during HIV-1 budding differs in crucial aspects from topologically related cellular abscission events.
Journal: Journal of Molecular Biology - Volume 410, Issue 4, 22 July 2011, Pages 525–533