Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase
Keywords: HIV-1 RT; p53; DNA synthesis; Uracil; Mutagenesis; Exonuclease;
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Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “Freeze” the pre-translocated complex during the polymerization catalytic cycle
Keywords: HIV-1; human immunodeficiency virus type 1; RT; reverse transcriptase; PPi; inorganic pyrophosphate; NTP; nucleoside triphosphate; NDP; nucleoside diphosphate; PFA; phosphonoformic acid, foscarnet; RNase H; ribonuclease H; CPHM; [2-(2-(4-chlorophenyl)hydr
Inhibition activities of catechol diether based non-nucleoside inhibitors against the HIV reverse transcriptase variants: Insights from molecular docking and ONIOM calculations
Keywords: ONIOM; Molecular docking; Catechol diether; HIV-1 RT; Non-nucleotide inhibitors;
Parallel screening of drug-like natural compounds using Caco-2 cell permeability QSAR model with applicability domain, lipophilic ligand efficiency index and shape property: A case study of HIV-1 reverse transcriptase inhibitors
Keywords: Parallel screening; HIV-1 RT; Docking; QSAR; Natural compounds; Lipophilic ligand efficiency; DAMFIVLRNUMVEJ-UHFFFAOYSA-N;
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines
Keywords: HIV-1 RT; Imidazo[1,2-a]pyrazines; Core-refining; NNRTIs; Biological activity; Molecular simulation
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches
Keywords: Triazolopyrimidines; Structure-based drug design; Biological activity; HIV-1 RT; Physicochemical properties; Molecular simulations
ZnO-mediated regioselective C-arylsulfonylation of indoles: a facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)
Keywords: Regioselectivity; C-Arylfonylation; Indoles; Non-nucleoside inhibitor; HIV-1 RT;
Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents
Keywords: Anti-HIV-1 agents; NNRTIs; Uracil analogs; Molecular modeling analysis; HIV-1 RT;
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2â²-deoxyadenosine 5â²-triphosphate as inhibitors of HIV-1 reverse transcriptase
Keywords: HIV-1 RT; Cyclobutyl adenosine analogs; Tenofovir; K65R mutant of RT; Pre-steady state kinetics;
In vitro antibacterial, antioxidant, total phenolic contents and anti-HIV-1 reverse transcriptase activities of extracts of seven Phyllanthus sp
Keywords: Antibacterials; DPPH; HIV-1 RT; Phyllanthus species; Total phenols
Simple and rapid determination of the enzyme kinetics of HIV-1 reverse transcriptase and anti-HIV-1 agents by a fluorescence based method
Keywords: HIV-1 RT; HIV-1 reverse transcriptase; NNRTI; non-nucleotide reverse transcriptase inhibitor; dTTP; deoxyribonucleotide triphosphate; HIV-1 reverse transcriptase; Fluorometric method; High-throughput screening; Anti-HIV agents; PicoGreen;
Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico
Keywords: Calophyllum brasiliense; Calanolides; HIV-1 RT; Toxicity;
Synthesis, structure–activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs
Keywords: Dideoxythymidine; NRTIs; VSV; HIV-1; HIV-1 RT; MTT assay
Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
Keywords: HIV-1 RT; NNRTIs; S-DABO analogues; Docking
Quantitation of human immunodeficiency virus type 1 viral load in plasma using reverse transcriptase activity assay at a district hospital laboratory in Botswana: A decentralization pilot study
Keywords: HIV-1 RNA; HIV-1 RT; Viral load; Cavidi ExaVir Load; Roche COBAS Amplicor; Resource limited
QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains
Keywords: HIV-1 RT; NNRTIs; DAPYs; Hydrophobicity index; 2D-QSAR
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents
Keywords: 4-Thiazolidinones; Anti-HIV-1 activity; HIV-1 RT; NNRTIs; QSAR
Active site dynamics and combined quantum mechanics/molecular mechanics (QM/MM) modelling of a HIV-1 reverse transcriptase/DNA/dTTP complex
Keywords: HIV-1 RT; AIDS; Molecular dynamics; QM/MM; Semiempirical method
Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: A dual mechanism approach
Keywords: hTR; human telomerase RNA component; TP1; telomerase-associated protein 1; hTERT; human telomerase reverse transcriptase; PUFAs; polyunsaturated fatty acids; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; LDH; lactate dehydrogenase; PBS; phosphate