Keywords: 18S; 18S ribosomal RNA; 36B4; acidic ribosomal protein 36B4; Acc1; acetyl-CoA carboxylase α; Acox1; acyl-CoA oxidase 1; Apob; apolipoprotein B; ARE; antioxidant response element; AST; aspartate aminotransferase; ALT; alanine aminotransferase; ATF4; activ
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Keywords: AI; anaemia of inflammation; ARE; anti-oxidant responsive element; ATP; adenosine triphosphate; Bmp; bone morphogenetic protein; CD; cluster of differentiation; C/EBP; CCAAT enhancer-binding protein; CO; carbon monoxide; CREB; cyclic adenosine monophospha
Glyceollins: Soybean phytoalexins that exhibit a wide range of health-promoting effects
Keywords: 3T3-L1; mouse fibroblast cell line; 4CL; 4-coumarate:coenzyme A ligase; ABTS; 2,2â²-azinobis(3-ethylbenzthiazoline-6-sulfonate); ACC; acetyl-coA carboxylase; AKT; protein kinase B; AMPK; adenosine-monophosphate kinase; Ang-1; angiopoietin-1; BCRP; breast
Keywords: 2OAA; 2-hydroxyarachidonic acid; 4-HNE; 4-hydroxynonenal; AA; arachidonic acid; C-Pu; caudate-putamen; CCA; common carotid artery; cPLA2; cytosolic phospholipase A2; COX; cyclooxygenase; DHA; docosahexaenoic acid; ECA; external carotid artery; FFA; free f
Keywords: BD; brain death; CCL2; chemokine ligand 2; CCL12; chemokine ligand 12; Eif2b1; eukaryotic translation initiation factor 2B subunit alpha; ELISA; enzyme-linked immunosorbent assay; Estat,RS; static elastance of the respiratory system; FiO2; fraction of ins
Keywords: Apoe-/-; apolipoprotein E gene knockout; CVD; cardiovascular disease; DTPA; diethylenetriaminepentaacetic acid; HAEC; human aortic endothelial cells; Hmox1; heme oxygenase-1; HOCl; hypochlorous acid; HSA; human serum albumin; Keap1; Kelch-like ECH-ass
Keywords: CD; cluster of differentiation; DE; diesel exhaust; FPG; formamidopyrimidine DNA glycosylase; hOGG1; human 8-oxoguanine DNA glycosylase; HMOX1; heme oxygenase (decycling-1); IL8; interleukin 8; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; PBMCs; periph
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BMI; body mass index; BMP; bone morphogenetic protein; GGT; gamma-glutamyl transferase; HIF1A; hypoxia inducible factor 1; HMOX1; heme oxygenase (decycling) 1; IRIDA; iron-refractory iron-def
Keywords: Antioxidant enzymes; Brain; Inflammation; Nanoparticles; Oxidative stress; Renin-angiotensin system; ACTB; beta actin; APP; amyloid β (A4) precursor protein; APx; ascorbic acid peroxidase; ARO; aromatase; ANG; angiotensin; ACE; angiotensin converting e
Keywords: BR, bilirubin; ROS, reactive oxygen species; CYP, cytochrome P450; CYP2A5, cytochrome P450 2A5; HMOX1, heme oxygenase-1; UGT1A1, UDP-glucuronosyltransferase 1A1; BVR, biliverdin reductaseMitochondria; CYP2A5; HMOX1; Bilirubin; Oxidative stress; Endoplasmi
Keywords: ABCA1; ATP-binding cassette, subfamily A, member 1; ABCG5; ATP-binding cassette, subfamily G, member 5; ACD; anemia of chronic disease; AI; anemia of inflammation; Apo; apolipoprotein; Arg1; arginase-1; Bach1; Btb and Cnc Homology, basic leucine zipper tr
Keywords: FDR; False discovery rate; HMOX1; Heme Oxygenase-1; LD; Linkage disequilibrium; TcB; Transcutaneous bilirubin; UGT1A1; Uridine Diphosphate Glucuronosyl Transferase 1A1;
Keywords: Antioxidants; asthma; diet; C-ACT; Childhood Asthma Control Test; CAT; Catalase; GST; Glutathione-S-transferase; GSTM1; Glutathione-S-transferase Mu1; GSTP1; Glutathione-S-transferase Pi1; GSTT1; Glutathione-S-transferase theta1; HMOX1; Heme oxygenase 1;
Keywords: Aging; BALB/c mice; Broccoli; Inflammation; LPS; Sulforaphane; ARE; antioxidant response element; CYBB; cytochrome b-245 β; GFAP; glial fibrillary acidic protein; HMOX1; heme oxygenase I; IL; interleukin; LPS; lipopolysaccharide; MHC-II; major histocompa
Keywords: Breast cancer prognosis; Oxidative stress; Genetic variants; Effect modification; Radiotherapy; BCSS; breast cancer-specific survival; CAT; catalase; CI; confidence interval; CTx; chemotherapy; CYBA; cytochrome b-245 alpha polypeptide; ER; oestrogen recep
4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells
Keywords: Chemoprevention; Isothiocyanate; 4-Methylthio-3-butenyl isothiocyanate; Nuclear factor (erythroid-derived 2)-like 2; Reactive oxygen species; AITC; allyl isothocyanate; AP-1; activator protein-1; BITC; butyl isothiocyanate; ERK; extracellular signal-regul
Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
Keywords: AD; Alzheimer's Disease; ADP; Adenosine diphosphate; Aβ; β-amyloid; CAW; Water extract of Centella asiatica; CFR; Conditioned fear response; ETC; Electron transport chain; FCCP; Carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone; GAPDH; Glyceraldehyde
Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells
Keywords: BNF; beta-naphthoflavone; CCL; C-C motif chemokine ligand; CT; cytotrophoblast; CXCL; C-C-X-C motif chemokine ligand; CYP; cytochrome P450 enzyme superfamily; ELOVL4; fatty acid elongase 4; EVCT; extravillous cytotrophoblast; GEO; Gene Expression Omnibus;
Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure
Keywords: α/β-Cardiac Myosin; Heavy chain Alpha and Beta Cardiac Myosin; ABCG2; ATP-Binding Cassette sub-family G member 2; ANOVA; Analysis of Variance; DMEM; Dulbecco's Modified Eagle Medium; DMSO; Dimethyl Sulfoxide; DPBS; Dulbecco's Phosphate-Buffered Sali
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Effects of mild ozonisation on gene expression and nuclear domains organization in vitro
Keywords: SH-SY5Y; Human neuroblastoma cell line; HMOX1; Heme Oxygenase 1; ERCC4; Excision Repair Cross-Complementation Group 4; CDKN1A; Cyclin-Dependent Kinase Inhibitor 1A; CTDSP1; CTD Small Phosphatase 1; Ozone; Human neuroblastoma cells; Cell nucleus; Transmiss
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium
Keywords: 129; 129S1/SvimJ; B6; C57BL6/J; DKO; double knockout of GPx1 and GPx2 genes; DUOX 2; dual oxidase-2; Duoxa; Duox activator; Duoxa-TKO; triple-knockout mice with disrupted Duoxa, GPx1 and GPx2 genes; DSS; dextran sodium sulfate; DTI; di-2-thienyliodonium;
Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury
Keywords: Acute kidney injury (AKI); heme oxygenase 1 (HO-1); renal failure; translational research; cytoprotection; pathophysiology; oxidative stress; inflammation; cell cycle regulation; autophagic response; biomarker; HMOX1; review;
Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
Keywords: Gallstone; NAFLD; Hypoxia; Aquaporin-8; AQP; aquaporin; CCD; cholesterol and cholate-rich diet; cDNA; complementary DNA; HIF1; hypoxia-inducible factor 1; HIF1α; hypoxia-inducible factor 1 α subunit; Hmox1; heme oxygenase-1; IBDU; isolated bile duct uni
Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells
Keywords: FMO3; Flavin-containing monoxygenase-3; NRF2; Nuclear factor (erythroid-derived 2)-like 2; KEAP1; Kelch-like ECH-associated protein 1; NQO1; NAD(P)H:quinone oxidoreductase-1; HMOX1; heme oxygenase-1; tBHP; tert-butyl hydroperoxide; tBHQ; tert-butyl hydroq
Induced peroxidase and cytoprotective enzyme expressions support adaptation of HUVECs to sustain subsequent HâOâ exposure
Keywords: Oââ; Â superoxide; HâOâ; hydrogen peroxide; ROS; reactive oxygen species; DHE; dihydroethidium; EC; endothelial cell; HUVEC; human umbilical vein endothelial cell; eNOS; constitutive nitric oxide synthase; SOD1; superoxide dismutase 1; SOD2; super
Nitrosopersulfide (SSNOâ) targets the Keap-1/Nrf2 redox system
Keywords: Hmox1; heme oxygenase-1; Keap-1; Kelch-like ECH-associated protein; SSNOâ; nitrosopersulfide; Nrf2; nuclear factor (erythroid-derived 2)-like 2; PDE; phosphodiesterase; sGC; soluble guanylate cyclase; NO and H2S cross talk; Nitroxyl; Nitrosopersulfide;
Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma
Keywords: OSCC; Oral Squamous Cell Carcinoma; miRNA; MicroRNA; NGS; Next Generation Sequencing; STRING; Search Tool for Retrieval of Interacting Genes/Proteins; ACTREC; Advanced Centre for Treatment Research and Education in Cancer; HNOCDB; Head Neck Oral Cancer Da
Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria
Keywords: Cerebral malaria; Heme; Microglia; Astrocyte; Inflammation; Hmox1;
Magnolia officinalis (Hou Po) bark extract stimulates the Nrf2-pathway in hepatocytes and protects against oxidative stress
Keywords: ARE; antioxidant response element; GCLC; glutamate-cysteine ligase catalytic subunit; Hepa1c1c7; murine hepatoma cells; HepG2; human hepatoma cells; HMOX1; heme oxygenase-1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; Keap1; Kelch-like ECH-associated
Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP
Keywords: Nrf2; Keap1; GSK-3; PKB/Akt; PI3K; PTEN; β-TrCP; ARE; antioxidant response element; tBHQ; tert-butyl hydroquinone; bZIP; basic-region leucine zipper; CDDO-Im; 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; CNC; cap'n'collar; Cul1; cullin-1; Cu
Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients
Keywords: ACO1; acotinase 1; AD; Alzheimer's disease; ANCOVA; univariate analysis of co-variance; APP; amyloid-beta precursor protein; Aβ; amyloid-beta; CDR; Clinical Dementia Rating; Cp; ceruloplasmin; CPO; Cp oxidase activity; eQTLs; expression quantitative trai
In vivo toxicity of cationic micelles and liposomes
Keywords: 8-oxodG; 8-oxo-7,8-dihydroguanine; ATP; Adenosine triphosphate; BW; Body weight; CCL2; Chemokine C-C motif ligand 2; cDNA; Complementary DNA; CNS; Central nervous system; Comet; Single Cell Gel Electrophoresis assay; CXCL2; Chemokine C-X-C motif ligand 2;
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators
Keywords: Nrf2; Keap1; Protein-protein interaction; Transcription factor; Cul3; Keap1/Nrf2 interaction; BTB; Broad complex, Tramtrack and Bric-Ã -Brac; LE; Ligand efficiency; DMEM; Dubecco's modified Eagle's medium; FBS; fetal bovine serum; HMOX1; heme oxygenase
A rapid in vivo zebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity
Keywords: PCB126; 3,3â²,4,4,5-pentachlorobiphenyl; AhR; aryl hydrocarbon receptor; NAC; N-acetylcysteine; SOD; superoxide dismutase; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; HPLC; high-performance liquid chromatography; GSH; gl
Effect of 5-aminolevulinic acid on erythropoiesis: A preclinical in vitro characterization for the treatment of congenital sideroblastic anemia
Keywords: CSA; congenital sideroblastic anemia; ALA; 5-aminolevulinic acid; ALAS2; 5-aminolevulinic acid synthase 2; HBA; hemoglobin alpha; HBG; hemoglobin gamma; HMOX1; heme oxygenase 1; GABA; gamma-aminobutyric acid; HiDEP; human induced pluripotent stem cell-der
Neural HO-1/sterol interactions in vivo: Implications for Alzheimer's disease
Keywords: 3xTg-AD; triple transgenic AD mouse; 4β-OH; 4β-hydroxycholesterol; 7α-OH; 7α-hydroxycholesterol; 7β-OH; 7β-hydroxycholesterol; 7keto-CH; 7-ketocholesterol; 24-OH; 24-hydroxycholesterol; Aβ; β-amyloid; AD; Alzheimer-disease; APP; amyloid precursor
Combining metabolomic analysis and microarray gene expression analysis in the characterization of the medicinal plant Chelidonium majus L
Keywords: Chelidonii herba; Herbal safety; Gene expression profiling; 1H-NMR fingerprint; IPA; Ingenuity pathway analysis; PCA; Principal component analysis; qRT-PCR; quantitative real-time PCR; AhRR; Aryl-hydrocarbon receptor repressor; AKR1B10; Aldo-keto reductas
Comparison of the molecular topologies of stress-activated transcription factors HSF1, AP-1, NRF2, and NF-κB in their induction kinetics of HMOX1
Keywords: Modelling; Gene regulatory network; Oxidative stress; Denatured protein; HMOX1; Network topology; Transcription factor
Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line
Keywords: AOX1; aldehyde oxidase 1; ARE; antioxidant response element; B2M; β-2-micoglobulin; BDE-47; 2,2â²,4,4â²-tetra-BDE; BSO; buthionine sulfoximine; CMV; cytomegalovirus; COX-2; cyclooxygenase-2; DHCR24; 24-dehydrocholesterol reductase; DMSO; dimethyl sulfo
Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
Keywords: Nrf2; nuclear factor-erythroid 2-related-2; NQO1; NAD(P)H quinone oxidoreductase 1; HMOX1; heme oxygenase 1; GCLM; modifier subunit for glutamate-cysteine ligase; γ-GCSm; γ-glutamylcysteine synthase regulatory subunit; Keap1; Kelch-like ECH-associated
Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels
Keywords: Heat shock factor 1; Amino acid deprivation; Methionine; DNAJB1; NRF2; GCN2; general non-derepressible 2; ATF; activating transcription factor; ASNS; asparagine synthetase; SAM; S-adenosylmethionine; HMOX1; heme oxygenase 1; GSTP; glutathione S-transferas
Reduced in vitro toxicity of fine particulate matter collected during the 2008 summer Olympic Games in Beijing: The roles of chemical and biological components
Keywords: BC; black carbon; DPBS; Dulbecco's phosphate-buffered saline; EC; element carbon; GOI; gene of interest; HC; high control; Hmox1; heme oxygenase 1; ICP-MS; inductively coupled plasma mass spectrometry; LC; low control; LDH; lactate dehydrogenase; LPS; l
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway
Keywords: ARE; antioxidant-response element; AP-1; activator protein-1; DEM; diethyl maleate; GCLC; glutamate-cysteine ligase, catalytic subunit; GCLM; glutamate-cysteine ligase, modifier subunit; GSH; glutathione; GSTA4; glutathione S-transferase Alpha 4; HMOX
Chronic Cyclic Bladder Over Distention Up-Regulates Hypoxia Dependent Pathways
Keywords: urinary bladder; oxidative stress; anoxia; gene expression; urinary bladder neck obstruction; Arnt2; arylhydrocarbon receptor nuclear translocator 2; Ctgf; connective tissue growth factor; F2-IsoP; F2-isoprostane; Glut-1; glucose transporter 1; Gpx1; glut
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
Keywords: 18S; 18S ribosomal RNA; ARE; antioxidant response element; DMA3 +; dimethylarsinous acid; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GCLC; γ-glutamate cysteine ligase catalytic subunit; GSIS; glucose-stimulated insulin secretion;
The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
Keywords: BCA; bicinchoninic acid; bZip; basic leucine zipper; CLIP; cross-linking immunoprecipitation; CO; carbon monoxide; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HITS; high-throughput sequ
Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension
Keywords: Ang II; angiotensin II; DAPI; 4,6-diamidino-2-phenylindole dichlorohydrate; DHE; dihydroethidium; DOCA; deoxycorticosterone acetate; DPI; diphenylene iodonium; eNOS; endothelial nitric oxide synthase; ET-1; endothelin-1; GCLC; γ-glutamylcysteine syntheta