دانلود مقالات ISI درباره htt، huntingtin + ترجمه فارسی

سیکلین وابسته به کیناز 5 فسفریله می کند و باعث تخریب اتاکسین-2 می شود

Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2

Keywords: htt، huntingtin; Ataxin-2; Cdk5; SCA2; Phosphorylation; Proteasomal degradation; PolyQALS, amyotrophic lateral sclerosis; Cdk5, cyclin-dependent kinase 5; HD, Huntington's disease; htt, huntingtin; SCA, spinocerebellar ataxia; SDS-PAGE, sodium dodecyl sulfate polyacrylami

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure

Keywords: htt، huntingtin; Endosulfan; Neuroblastoma cells (SH-SY5Y); Genomics; ProteomicsAPI5, Apoptosis inhibitor 5; AIFM2, Apoptosis-inducing factor mitochondrion-associated 2; HTT, Huntingtin; FOS, FBJ murine osteosarcoma viral oncogene homolog; FADD, Fas (TNFRSF6)-associated v

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Changes in structure and function of diaphragm neuromuscular junctions from BACHD mouse model for Huntington's disease

Keywords: htt، huntingtin; Synaptic vesicles; Neuromuscular junction; Exocytosis; BACHD; Huntington diseaseACh, acetylcholine; htt, huntingtin; mtt, mutant huntingtin; HD, Huntington's disease; MEPP, miniature endplate potential; NMJ, neuromuscular junction; VAChT, vesicular acetyl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease

Keywords: htt، huntingtin; AcH4, acetylated histone H4; ChIP, chromatin immunoprecipitation; HD, Huntington's Disease; HTT, Huntingtin; HSE, heat shock element; HSF1, heat shock factor 1; HSPs, heat shock proteins; HSR, heat shock response; HYPK, Huntingtin Yeast Partner K; qRT-PCR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

Keywords: htt، huntingtin; HD, Huntington's disease; PGE2, prostaglandin E2; BDNF, brain-derived neurotrophic factor; htt, huntingtin; mhtt, mutant huntingtin; NORT, novel object recognition test; T-SAT, T-spontaneous alternation task; NIIs, neuronal intra-nuclear inclusions; GFAP,

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Nucleolar dysfunction in Huntington's disease

Keywords: htt، huntingtin; HD, Huntington's disease; htt, huntingtin; mthtt, mutant htt; MSNs, medium spiny neurons; rDNA, ribosomal DNA; rRNA, ribosomal RNA; UBF, upstream binding factor; HAT, histone acetyltransferase; Pol I, RNA polymerase I; HMT, histone methyltransferase; CBP,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease

Keywords: htt، huntingtin; BDNF, brain-derived neurotrophic factor; CAG, cytosine-adenine-guanine trinucleotide; EE, environmental enrichment; F-actin, actin filaments; HD, Huntington’s disease; htt, huntingtin; LTD, long-term depression; LTP, long-term potentiation; PSD, postsynap

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

Keywords: htt، huntingtin; HTT, Huntingtin; HD, Huntington's disease; ES, Embryonic stem; NS, Neural stem; iPS, Induced pluripotent stem cell; BLBP, Brain lipid-binding protein; SOX2, SRY (sex determining region Y)-box 2; GFAP, Glial fibrillary acidic protein; BDNF, Brain-derived n

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

α-Synuclein modifies huntingtin aggregation in living cells

Keywords: htt، huntingtin; Htt, huntingtin; α-syn, α-synuclein; HD, Huntington’s disease; PD, Parkinson’s disease; AD, Alzheimer’s disease; BiFC, bimolecular fluorescence complementation assayHuntingtin; α-Synuclein; Co-aggregation; Bimolecular fluorescence complementation assay

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Induced pluripotent stem cell lines from Huntington's disease mice undergo neuronal differentiation while showing alterations in the lysosomal pathway

Keywords: htt، huntingtin; iPS, induced pluripotent stem cells; HD, Huntington's disease; wt, wild type; HTT, huntingtin; BDNF, brain-derived neurotrophic factor; PH3, phospho-histone H3; PI, propidium iodide; GFAP, glial fibrillary acid protein; MAP2ab, microtubule-associated prot

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

Keywords: htt، huntingtin; iPS, induced pluripotent stem; HD, Huntington's disease; WT, wild type; HTT, huntingtin; PH3, phospho-histone H3; MEF, mouse embryonic fibroblasts; EBs, embryoid bodies; ES, embryonic stemHuman induced pluripotent stem cells; Huntington's disease; Neurona

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease

Keywords: htt، huntingtin; HD, Huntington's disease; htt, huntingtin; polyQ, polyglutamine; TG2, tissue transglutaminase; WT, wild type; MSN, medium spiny neuronHuntington's disease; Transglutaminase; Mouse model; Phenotype; Modifiers; Aggregates

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

Keywords: htt، huntingtin; polyQ, polyglutamine; htt, huntingtin; wt, wild type; HA, hemagglutinin; IP, immunoprecipitation; PDB, Protein Data Bank; CDR, complementarity-determining region; SAXS, small-angle X-ray scattering; Cer, Cerulean fluorescent protein; MBP, maltose binding

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF

Keywords: htt، huntingtin; HD, Huntington's disease; htt, huntingtin; mhtt, mutant huntingtin; htt552, N-terminal huntingtin fragment 1–552 aa; BDNF, brain-derived neurotrophic factor; ACM, astrocyte conditioned mediumAstrocytes; Huntington's disease; Brain-derived neurotrophic fac

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

Keywords: htt، huntingtin; polyQ, polyglutamine; HD, Huntington's disease; htt, huntingtin; FCS, fluorescence correlation spectroscopy; httNT, htt 17-amino acid N-terminus; AUC, analytical ultracentrifugation; GFP, green fluorescent protein; FTIR, Fourier transform infrared spectro

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2012 سفارش ترجمه

Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation

Keywords: htt، huntingtin; HD, Huntington’s disease; polyQ, polyglutamine; htt, huntingtin; IP3, inositol 1,4,5-trisphosphate; IP3R1, IP3 receptor type 1; 2-APB, 2-aminoethyl diphenylborinate; ER, endoplasmic reticulum; MSN, medium spiny neurons; Neuro2a cells, mouse neuroblastoma

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1

Keywords: htt، huntingtin; huntingtin; hippocampus; neuroblasts; transcriptional dysregulation; transgenic miceBmal1, brain and muscle Arnt-like protein-1; Dcx, doublecortin; DG, dentate gyrus; HAP1, huntingtin associated protein 1; HD, Huntington's disease; Htt, huntingtin; mPer1,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Amyloid in neurodegenerative diseases: Friend or foe?

Keywords: htt، huntingtin; htt, huntingtin; HD, Huntington's disease; AD, Alzheimer's disease; CC, coiled-coil; (polyQ), polyglutamine; IB, inclusion body; APP, amyloid precursor protein; FRET, fluorescence resonance energy transfer; LTP, long-term potentiation; PQC, protein qualit

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

Keywords: htt، huntingtin; AD, Alzheimer's Disease; APP, amyloid precursor protein; Aβ, amyloid β peptide; KGDHC, α-ketoglutarate dehydrogenase complex; ETC, electron transport chain; Htt, huntingtin; HD, Huntington's Disease; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3NP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers

Keywords: htt، huntingtin; DCS, differential scanning calorimetry; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; EPA, ethyl-eicosapentaenoic acid; GABA, γ-aminobutyric acid; HD, Huntington disease; htt, huntingtin; LUVs, large unilamellar vesicles; PC, phosphatidylcholine; PE,

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

The Predicted Structure of the Headpiece of the Huntingtin Protein and Its Implications on Huntingtin Aggregation

Keywords: htt، huntingtin; Htt, Huntingtin; N17Htt, N-terminal 17 residues in the first exon of the Htt protein; ST, simulated tempering; MD, molecular dynamics; PEDF, potential energy distribution function; LR, Lifson–RoigFolding@Home; Huntington's Disease; N17Htt; Molecular Dynam

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease

Keywords: htt، huntingtin; HD, Huntington's Disease; HTT, human Huntington's disease gene; htt, huntingtin; CREB, cAMP response element-binding protein; Sp1, specificity protein 1; CBP, CREB-binding protein; TBP, TATA binding box protein; COUP-TF, chicken ovalbumin upstream promote

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

An scFv Intrabody against the Nonamyloid Component of α-Synuclein Reduces Intracellular Aggregation and Toxicity

Keywords: htt، huntingtin; syn, synuclein; NAC, nonamyloid component; scFv, single-chain variable fragment; PD, Parkinson's disease; htt, huntingtin; SAPE, streptavidin-R-phycoerythrin; CDR, complementarity-determining region; NLS, nuclear localization signal; DAPI, 4′,6-diamidino-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Drug targeting of dysregulated transcription in Huntington's disease

Keywords: htt، huntingtin; HD, Huntington's Disease; Htt, Huntingtin; IND, Investigational New Drug; HAT, Histone Acetyl Transferase; HDAC, Histone deacetylase; SAHA, Suberoylanilide hydroxamic acid; Sir2, Silent Information Regulator (Sirtuin); SirT1, Sirtuin 1; SirT2, Sirtuin 2;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

Keywords: htt، huntingtin; ER, endoplasmic reticulum; htt, huntingtin; httN, htt exon I or the N-terminal 588 amino acids with various numbers of glutamines; ERAD, ER-associated degradation; GST, glutathione S-transferase; HA, hemagglutinin; IB, immunoblotting; IP, immunoprecipitat

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه