Keywords: هپاتوسیت های انسانی; 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
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Keywords: هپاتوسیت های انسانی; Microtissue spheroids; Human hepatocytes; Hollow fiber bioreactor; Oxygen uptake; Mass transfer;
Hepatitis B virus X protein modulates cytosolic Ca2+ signaling in primary human hepatocytes
Keywords: هپاتوسیت های انسانی; Hepatitis B virus; Human hepatocytes; Calcium; Store-operated calcium entry; Mitochondria;
Essential oils of culinary herbs and spices activate PXR and induce CYP3A4 in human intestinal and hepatic in vitro models
Keywords: هپاتوسیت های انسانی; AhR; aryl hydrocarbon receptor; EO; essential oil; EtOH; ethanol; CAR; constitutive androstane receptor; GR; glucocorticoid receptor; PXR; pregnane X receptor; RIF; rifampicin; VDR; vitamin D receptor; Food-drug interactions; Human hepatocytes; Essential
Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach
Keywords: هپاتوسیت های انسانی; Cytochrome P450; Drug-drug interactions; Degradation rate constant; Human hepatocytes; Mechanism-based inhibition; Physiologically-based pharmacokinetic modelling; Small-interfering RNA; Half-life; Time-dependent inhibition;
Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter
Keywords: هپاتوسیت های انسانی; Entecavir; Tenofovir; Organic anion transporter; Human hepatocytes; Hepatitis B;
Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
Keywords: هپاتوسیت های انسانی; Isoniazid; N-Acetyltransferase 2; Acetylation polymorphism; Human hepatocytes; Genotype; Phenotype;
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: هپاتوسیت های انسانی; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes
Keywords: هپاتوسیت های انسانی; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; DRE; dioxin responsive element; DMEM; Dulbecco modified Eagle medium; DMSO; dimethylsulfoxide; EMSA; electrophoretic mobility shift assay; EROD; 7-
Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver
Keywords: هپاتوسیت های انسانی; NK Cell; CXCL10; Mouse Model; IL10; HBe; cccDNA; covalently closed circular DNA; CHB; chronically HBV infected; ELISA; enzyme-Linked Immunosorbent Assay; ETV; entecavir; hAlb; human Albumin; HBcAg; hepatitis B core antigen; HBe; hepatitis B envelope; HBs;
Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study
Keywords: هپاتوسیت های انسانی; Human hepatocytes; Mycophenolate mofetil; UGT1A; GPX1
Activation-dependent mitochondrial translocation of Foxp3 in human hepatocytes
Keywords: هپاتوسیت های انسانی; Foxp3; Human hepatocytes; HepG2 cell line; Hepatitis B virus antigens; Core; Pre 1/2; Subcellular shuttling; OMM
Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles
Keywords: هپاتوسیت های انسانی; Drug induced liver injury; Acute liver failure; Oxidative stress; In vitro toxicity testing; Human hepatocytes; Drug development
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries
Keywords: هپاتوسیت های انسانی; Hepatotoxicity; DILI; Idiosyncratic hepatotoxicity; Individual differences; Risk factors; P450; CYP3A4; Acetaminophen; Cyclophosphamide; Ketoconazole; Tamoxifen; Human hepatocytes
Different responses of primary normal human hepatocytes and human hepatoma cells toward cyanobacterial hepatotoxin microcystin-LR
Keywords: هپاتوسیت های انسانی; Microcystin-LR; Human hepatocytes; Hepatotoxicty; Protein phosphatase 2A (PP2A) inhibition assay
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes
Keywords: هپاتوسیت های انسانی; Human hepatocytes; CYP3A4; TAT; PXR; AhR
The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes
Keywords: هپاتوسیت های انسانی; Transplant drugs; Cytochrome P450; Human hepatocytes; Drug interaction; Xenoreceptors;
Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells
Keywords: هپاتوسیت های انسانی; Pesticides; Mixture; Low doses; Human hepatocytes; Micronucleus assay;
Mass spectrometric investigation of chelerythrine and dihydrochelerythrine biotransformation patterns in human hepatocytes
Keywords: هپاتوسیت های انسانی; Chelerythrine; Dihydrochelerythrine; Benzo[c]phenanthridines; Metabolic transformation; Human hepatocytes;
A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes
Keywords: هپاتوسیت های انسانی; Arsenic; Nrf2; Anti-oxidant response; Human hepatocytes; Indirect response modeling;
Application of exogenous mixture of glutathione and stable isotope labeled glutathione for trapping reactive metabolites in cryopreserved human hepatocytes. Detection of the glutathione conjugates using high resolution accurate mass spectrometry
Keywords: هپاتوسیت های انسانی; Glutathione conjugation; Troglitazone; Reactive metabolites; Stable isotope label; LC–HRAMS; Human hepatocytes
Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells
Keywords: هپاتوسیت های انسانی; Sanguinarine; Antioxidant; Heme oxygenase-1; Thioredoxin 1; Nrf2; Human hepatocytes
Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclo
Keywords: هپاتوسیت های انسانی; Animal alternatives; In vitro toxicology; Metabolic activation; Detoxification; Human hepatocytes
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
Keywords: هپاتوسیت های انسانی; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch
Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds
Keywords: هپاتوسیت های انسانی; AFB1; Transcriptomics; Genotoxic compounds; Biomarker; FHIT; Human hepatocytes; HepaRG cells; Non-genotoxic compounds
Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin derivatives against human cancer cell lines and primary human hepatocytes
Keywords: هپاتوسیت های انسانی; A2780; human ovarian carcinoma cell line; A2780cis; human ovarian carcinoma cisplatin-resistant cell line; A549; human Caucasian lung carcinoma; A9opy; E-2-[1-(9-anthryl)-3-oxo-3-prop-2-enylpyridine; AM; acetoxymethyl; cbdc; dianion of cyclobutane-1,1-dic
Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures
Keywords: هپاتوسیت های انسانی; α-Amanitin; Human hepatocytes; Apoptosis; Acetylcysteine; Benzylpenicillin; Intoxication; Amanita phalloides
Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis
Keywords: هپاتوسیت های انسانی; rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK-1/2; extracellular signal-regulated kinase 1/2; FCS; fetal calf serum; HGF; hepatocyte growth factor; LPS; lipopolysaccharide; MAP kinase; mitogen-activated prot
Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR
Keywords: هپاتوسیت های انسانی; Protopine; Allocryptopine; Human hepatocytes; Aryl hydrocarbon receptor; Cytochrome P450; Gene expression
Proteomic mapping of bezafibrate-treated human hepatocytes in primary culture using two-dimensional liquid chromatography
Keywords: هپاتوسیت های انسانی; Bezafibrate; N-Acetylcysteine; Human hepatocytes; Proteomic map; PF2D; Fractionation
Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H-R)
Keywords: هپاتوسیت های انسانی; Human hepatocytes; Reactive oxygen species; Apoptosis; Necrosis; Hypoxia; Liver injury;
Regulation of drug transporter expression by oncostatin M in human hepatocytes
Keywords: هپاتوسیت های انسانی; Drug transporters; Human hepatocytes; Inflammation; Oncostatin-M; Biliary elimination;
Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry
Keywords: هپاتوسیت های انسانی; Sanguinarine; Chelerythrine; Mass spectrometry; Biotransformation; Reduction and oxidation; Human hepatocytes
Human hepatocytes and endothelial cells in organotypic membrane systems
Keywords: هپاتوسیت های انسانی; Organotypic; Membrane; Human hepatocytes; Human endothelial cells; Chitosan; Liver tissue engineering
Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes
Keywords: هپاتوسیت های انسانی; Human hepatocytes; Cytochrome P450; Dinuclear copper(II) complexes; Gene inductionAhR, Aryl hydrocarbon receptor; CAR, Constitutive androstane receptor; CYP, Cytochrome P450; DRE, Dioxin-responsive element; HepG2, Human hepatoma cells; L1, 6-[(2-methoxybe
Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner
Keywords: هپاتوسیت های انسانی; Augmenter of liver regeneration; Human hepatocytes; Liver regeneration; AKT/PKB; ERK1/2; Liver specificity; AP-1; activator protein-1; rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK1/2; extracellular signal-reg
Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin
Keywords: هپاتوسیت های انسانی; Αlpha-amanitin; Benzylpenicillin; Acetylcysteine; Silibinin; Amanita phalloides; Intoxication; Human hepatocytes
Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes
Keywords: هپاتوسیت های انسانی; Troglitazone; Troglitazone sulphate; Human hepatocytes; Glutathione; In vitro cell toxicity; Oxidative stress
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
Keywords: هپاتوسیت های انسانی; Apoptosis; Bcl-2 proteins; Endoplasmic reticulum stress; Human hepatocytes; Nile Red; Steatosis; FFA; free fatty acid; NAFLD; nonalcoholic fatty liver disease; ER; endoplasmic reticulum; PERK; protein kinase RNA-like ER kinase; CHOP; CCAAT/enhancer bindin
Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
Keywords: هپاتوسیت های انسانی; Troglitazone; Reactive metabolites; Hepatotoxicity; Glutathione; Human hepatocytes; Thiazolidinedione
Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor
Keywords: هپاتوسیت های انسانی; Pesticide; Endosulfan; PXR; CAR; CYP3A4; CYP2B6; Human hepatocytes; HepG2 cell line
Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes
Keywords: هپاتوسیت های انسانی; Human hepatocytes; Cytochrome P450; Zolpidem; Enzyme induction
Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: Proof-of-concept study with aflatoxin B1
Keywords: هپاتوسیت های انسانی; Drug metabolism; Drug toxicity; In vitro toxicity; Aflatoxin B1; P450 isoforms; P450 inhibitors; 1-Aminobenzotrizole; Human hepatocytes; Cryopreservation
Hepatitis C virus is restricted at both entry and replication in mouse hepatocytes
Keywords: هپاتوسیت های انسانی; HCV; Entry; RNA replication; Restriction; Human hepatocytes; Mouse hepatocytes
Improved functions of human hepatocytes on NH3 plasma-grafted PEEK-WC-PU membranes
Keywords: هپاتوسیت های انسانی; Human hepatocytes; NH3 plasma; Liver specific functions; Cell morphology; Membranes;
In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes
Keywords: هپاتوسیت های انسانی; Chemoprevention; SR13668; 9-cis-UAB30; Pentamethylchromanol; Human hepatocytes; CYP1A2; CYP2B6; CYP3A4
Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes
Keywords: هپاتوسیت های انسانی; Enzyme induction; mRNA expression; Rat hepatocytes; Human hepatocytes
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Keywords: هپاتوسیت های انسانی; Liver X receptor agonists; Pregnane X receptor; T0901317; CYP3A4; CYP2B6; Human hepatocytes
Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
Keywords: هپاتوسیت های انسانی; Quercetin; Heme oxygenase-1 (HO-1); Human hepatocytes; Mitogen-activated protein kinase (MAPK); NF-E2 related factor 2 (Nrf2); Signaling pathway
Human hepatocyte functions in a galactosylated membrane bioreactor
Keywords: هپاتوسیت های انسانی; Bioreactor; Galactosylated membrane; Human hepatocytes; Liver-specific functions; Morphology;